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Author : Liqing Zang
Publisher : Frontiers Media SA
Page : 496 pages
File Size : 29,72 MB
Release : 2022-04-04
Category : Science
ISBN : 2889748324
Author : Angela L. Shamchuk
Publisher : Elsevier Inc. Chapters
Page : 69 pages
File Size : 30,25 MB
Release : 2013-05-29
Category : Medical
ISBN : 0128072172
Olfactory dysfunction, although caused by many factors including physical damage and genetic abnormalities, is an early stage symptom of several neurodegenerative diseases. Not only is the olfactory system subject to the specific histological abnormalities but patients also lose the capacities to detect, identify, and discriminate among odors. In addition to olfactory deficits, motor dysfunction is another prominent manifestation of these conditions. Recent studies have begun to create zebrafish (Danio rerio) models for neurodegenerative diseases. Despite successful execution, there remains a great deal of potential in testing the models using established methods of olfactory and motion assessment. This chapter discusses the current zebrafish models and suggests olfactory and motor endpoints for Parkinson's, Alzheimer's, Huntington's, multiple system atrophy, and amyotrophic lateral sclerosis.
Author : Sandra van 't Padje
Publisher :
Page : pages
File Size : 21,74 MB
Release : 2007
Category :
ISBN :
The FMR1 protein, FMRP, has been extensively studied due to its involvement in the fragile X syndrome, which is mainly characterised by mental retardation, macroorchidism and facial dysmorphologies. The FMR1 gene is transcriptionally inactivated by the methylation of its promoter region due to the expansion of a CGG repeat. Thus the fragile X syndrome is caused by the absence of the protein FMRP. FMRP is part of a small RNA binding protein family, which also include FXR1P and FXR2P. Due to the high homology of important functional domains and similar expression patterns in the brain, FXR1P and FXR2P are thought to have a similar function to FMRP. All three proteins are ubiquitously expressed with high expression in brain and testis. In addition, FXR1P is highly expressed in striated muscle tissue. The cellular function of the FXR proteins has been studied by the generation of knockout mouse models for all three genes. The Fmr1 KO mice display similar feature...
Author : Samuel Cartner
Publisher : Academic Press
Page : 720 pages
File Size : 19,55 MB
Release : 2019-11-22
Category : Science
ISBN : 0128124326
The Zebrafish in Biomedical Research: Biology, Husbandry, Diseases, and Research Applications is a comprehensive work that fulfills a critical need for a thorough compilation of information on this species. The text provides significant updates for working vivarium professionals maintaining zebrafish colonies, veterinarians responsible for their care and well-being, zoologists and ethologists studying the species, and investigators using the species to gain critical insights into human physiology and disease. As the zebrafish has become an important model organism for the study of vertebrate development and disease, organ function, behavior, toxicology, cancer, and drug discovery, this book presents an important resource for future research. Presents a complete view of the zebrafish, covering their biology, husbandry, diseases and research applications Includes the work of world-renowned authors Provides the first authoritative and comprehensive treatment of zebrafish in biomedical research as part of the ACLAM series
Author : Gokhan Dalgin
Publisher : Frontiers Media SA
Page : 157 pages
File Size : 39,91 MB
Release : 2019-12-06
Category :
ISBN : 2889632482
There are only a few vertebrate systems that can be used to model human diseases for biomedical discovery. The zebrafish model provides key advantages over existing models. Their externally developing embryos provide high-throughput non-invasive imaging, chemical screening, forward and reverse genetics, and their regeneration capacity make zebrafish a valuable system for novel discovery. Developmental studies using zebrafish has influenced discoveries in many human health-related conditions. This Research Topic covers all aspects of zebrafish studies, providing developmental mechanisms to human health conditions. The aim of the Research Topic was to foster a platform to bring all levels of zebrafish research including but not limited to development, disease, regeneration, drug screening, bioinformatics and Omics studies.
Author : National Research Council
Publisher : National Academies Press
Page : 348 pages
File Size : 35,51 MB
Release : 2000-12-21
Category : Nature
ISBN : 0309070864
Scientific Frontiers in Developmental Toxicology and Risk Assessment reviews advances made during the last 10-15 years in fields such as developmental biology, molecular biology, and genetics. It describes a novel approach for how these advances might be used in combination with existing methodologies to further the understanding of mechanisms of developmental toxicity, to improve the assessment of chemicals for their ability to cause developmental toxicity, and to improve risk assessment for developmental defects. For example, based on the recent advances, even the smallest, simplest laboratory animals such as the fruit fly, roundworm, and zebrafish might be able to serve as developmental toxicological models for human biological systems. Use of such organisms might allow for rapid and inexpensive testing of large numbers of chemicals for their potential to cause developmental toxicity; presently, there are little or no developmental toxicity data available for the majority of natural and manufactured chemicals in use. This new approach to developmental toxicology and risk assessment will require simultaneous research on several fronts by experts from multiple scientific disciplines, including developmental toxicologists, developmental biologists, geneticists, epidemiologists, and biostatisticians.
Author : Judith Axler Turner
Publisher : Elsevier Inc. Chapters
Page : 28 pages
File Size : 26,53 MB
Release : 2013-05-29
Category : Medical
ISBN : 0128071923
Identifying and selecting the most appropriate animal model is a challenge, but the U.S. Federal Government’s National Institutes of Health, has supported several efforts to make the job of finding disease models easier. These efforts began with support for databases about specific species, and have graduated to support for discipline-specific studies and cross-species resources. This article tracks LAMHDI, the initiative to Link Animal Models to Human DIsease (www.lamhdi.org), which brings together data about five species: flies, mice, rats, yeast, and zebrafish, and allows scientists to search across these data, principally by disease and gene. This chapter explains how LAMHDI was conceived, and where LAMHDI hopes to go in moving into phenotypical as well as genotypical data through networks and visualization.
Author : Prasan R. Bhandari
Publisher : Springer Nature
Page : 493 pages
File Size : 17,1 MB
Release : 2022-05-30
Category : Medical
ISBN : 9811652171
This book provides the latest information on the significance of zebrafish as an ideal model for researching the biomedical field, with references. This book also focused on the evidence of zebrafish as a model in cardiovascular, neurologic, psychiatric and metabolic research. In addition, the book also includes the research carried out on zebrafish in hepatic, renal, ophthalmic, and ENT related areas. Contributed chapters come from the most prominent laboratories working in this field, which provides a unique perspective on zebrafish models from a wide spectrum of the research community. In addition, the book offers a detailed analysis of the most current research in the area for specific zebrafish models including specific research in the area of skin disorders, endocrine diseases, nutritional disorders, gastrointestinal, hematological disorders and cancer. The compilation of chapters in the volume culminates into a comprehensive and definitive text on zebrafish and its suitability for modeling various diseases, providing a critical resource on the potential attributes of the zebrafish as a pharmacological model. In terms of scope, this book is a useful tool for young researchers, professors and pharmaceutical scientists for understanding the significance of zebrafish as an emerging pharmacological model that can significantly aid in the process of drug discovery and development.
Author :
Publisher : Academic Press
Page : 386 pages
File Size : 38,76 MB
Release : 2017-03-21
Category : Medical
ISBN : 0128033436
Zebrafish at the Interface of Development and Disease Research presents the latest on the shared pathways that govern development and contribute to disease. Zebrafish have traditionally been used to study vertebrate development, providing interesting data on the developmental processes and genes that are implicated in disease. This new release in the series contains informative discussions on congenital heart defects in zebrafish, the use of zebrafish in studying kidney development and disease, and muscle development, homeostasis and disease in zebrafish. Each chapter interweaves the study of zebrafish development and its application to the immune system, the kidney, liver, heart and others. The subject matter is unique - no single volume has pulled together the theme of development and disease with zebrafish as a centerpiece Leading experts in the field - all of them running zebrafish focused labs for each chapter
Author : James F. Amatruda
Publisher : Springer Nature
Page : 361 pages
File Size : 14,69 MB
Release : 2023-09-05
Category : Science
ISBN : 1071634011
This fully updated edition introduces new tools, models, and analytic insights that position the zebrafish even more strongly as an engine of discovery for developmental and disease biology. Beginning with a section exploring detailed methods for use of zebrafish to model a variety of human diseases, the book continues by illuminating the key ongoing role of the fish model in studies of the vertebrate nervous system, tools and approaches using zebrafish to study stem cell and regenerative biology, as well as techniques in genetics and genomics. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, as well as tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Zebrafish: Methods and Protocols, Third Edition serves as an invaluable guide to propel advances in developmental biology, disease modeling, and regeneration research using zebrafish and medaka as model systems.