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UPSTREAM AND DOWNSTREAM PROCESSING OF BIOPRODUCTS

Author : R. Puvanakrishnan
Publisher : MJP Publisher
Page : 241 pages
File Size : 41,64 MB
Release : 2019-06-20
Category : Technology & Engineering
ISBN :

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Microorganisms have been exploited for many centuries for the production of fermented foods and beverages and for bread-making. The production of alcoholic beverages using microbes was the first major industrialized process. The technology developed for large-scale brewing was adapted for other anaerobic processes such as acetone and butanol in the early 1900s. With the discovery of penicillins, rapid developments were made in the technology of submerged culture fermentation of aerobic microorganisms under controlled conditions. The advancements in microbiology and process biochemistry improved our ability to harness the potential of microorganisms through improved bioprocessing methods to manufacture new products with economic viability. Microbial derived bioproducts have been gaining importance in the food, pharmaceutical, textile, leather, cosmetic and chemical industries, and most important among them are therapeutic proteins and peptides, enzymes, antigens, vaccines, antibiotics, drugs, etc.Not all microbial production processes involve culture of the organism in liquid medium. Instead, the organism can be grown on the surface of a solid substrate. Solid substrate (or solid state) fermentation (SSF) is an established traditional technology in many countries, producing edible mushrooms, fungal- fermented foods and soy sauce. Before the development of processes in liquid culture, citric acid and some microbial enzymes were produced by SSF. Carbon composting is also a form of SSF.

Bioprocess Engineering

Author : Pau Loke Show
Publisher : CRC Press
Page : 210 pages
File Size : 35,10 MB
Release : 2019-05-24
Category : Medical
ISBN : 0429882521

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Bioprocess Engineering: Downstream Processing is the first book to present the principles of bioprocess engineering, focusing on downstream bioprocessing. It aims to provide the latest bioprocess technology and explain process analysis from an engineering point of view, using worked examples related to biological systems. This book introduces the commonly used technologies for downstream processing of biobased products. The covered topics include centrifugation, filtration, membrane separation, reverse osmosis, chromatography, biosorption, liquid-liquid separation, and drying. The basic principles and mechanism of separation are covered in each of the topics, wherein the engineering concept and design are emphasized. This book is aimed at bioprocess engineers and professionals who wish to perform downstream processing for their feedstock, as well as students.

Downstream Processing in Biotechnology

Author : Venko N. Beschkov
Publisher : Walter de Gruyter GmbH & Co KG
Page : 211 pages
File Size : 37,47 MB
Release : 2021-06-21
Category : Science
ISBN : 3110574004

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The current book gives an excellent insight into downstream processing technology and explains how to establish a successful strategy for an efficient recovery, isolation and purification of biosynthetic products. In addition to the overview of purification steps and unit operations, the authors provide practical information on capital and operating costs related to downstream processing.

Recovery of Bioproducts

Author : G. Schmidt-Kastner
Publisher :
Page : 130 pages
File Size : 46,32 MB
Release : 1993-01-01
Category : Biological products
ISBN : 9780901001795

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Preparative Chromatography for Separation of Proteins

Author : Arne Staby
Publisher : John Wiley & Sons
Page : 608 pages
File Size : 27,29 MB
Release : 2017-02-02
Category : Technology & Engineering
ISBN : 1119031176

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Preparative Chromatography for Separation of Proteins addresses a wide range of modeling, techniques, strategies, and case studies of industrial separation of proteins and peptides. • Covers broad aspects of preparative chromatography with a unique combination of academic and industrial perspectives • Presents Combines modeling with compliantce useing of Quality-by-Design (QbD) approaches including modeling • Features a variety of chromatographic case studies not readily accessible to the general public • Represents an essential reference resource for academic, industrial, and pharmaceutical researchers

Continuous Biomanufacturing

Author : Ganapathy Subramanian
Publisher : John Wiley & Sons
Page : 628 pages
File Size : 49,46 MB
Release : 2017-12-26
Category : Science
ISBN : 3527340637

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This is the most comprehensive treatise of this topic available, providing invaluable information on the technological and economic benefits to be gained from implementing continuous processes in the biopharmaceutical industry. Top experts from industry and academia cover the latest technical developments in the field, describing the use of single-use technologies alongside perfusion production platforms and downstream operations. Special emphasis is given to process control and monitoring, including such topics as 'quality by design' and automation. The book is supplemented by case studies that highlight the enormous potential of continuous manufacturing for biopharmaceutical production facilities.

Biomass and Biofuels from Microalgae

Author : Navid R. Moheimani
Publisher : Springer
Page : 373 pages
File Size : 23,53 MB
Release : 2015-04-11
Category : Technology & Engineering
ISBN : 3319166409

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This comprehensive book details the most recent advances in the microalgae biological sciences and engineering technologies for biomass and biofuel production in order to meet the ongoing need for new and affordable sources of food, chemicals and energy for future generations. The chapters explore new microalgae cultivation techniques, including solid (biofilm) systems, and heterotrophic production methods, while also critically investigating topics such as combining wastewater as a source of nutrients, the effect of CO2 on growth, and converting biomass to methane through anaerobic digestion. The book highlights innovative bioproduct optimization and molecular genetic techniques, applications of genomics and metabolomics, and the genetic engineering of microalgae strains targeting biocrude production. The latest developments in microalgae harvesting and dewatering technologies, which combine biomass production with electricity generation, are presented, along with detailed techno-economic modeling. This extensive volume was written by respected experts in their fields and is intended for a wide audience of researchers and engineers.