[PDF] Total Marrow Irradiation eBook

Author : Jeffrey Y. C. Wong
Publisher : Springer
Page : 0 pages
File Size : 48,30 MB
Release : 2021-03-01
Category : Medical
ISBN : 9783030386948

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This book, written by a team of international experts, concisely reviews the rationale and clinical application of image-guided total marrow irradiation, a rapidly emerging area in radiation oncology and hematopoietic cell transplantation. The aim is to provide the practicing radiation oncologist, hematologist, medical physicist, and bone marrow transplant researcher with a fundamental understanding of key aspects and an appreciation of the increasing significance of total marrow irradiation as conditioning for bone marrow transplantation. Detailed attention is paid to the impacts of recent advances in radiation therapy technology, functional PET and MRI, and understanding of the response of bone marrow to radiation. Full consideration is also given to the ways in which technological advances in image-guided radiation therapy have created new opportunities to treat bone marrow transplant patients with limited transplant options due to advanced disease, age, or co-morbidities. Further topics covered include the ways in which cancer stem cells and the marrow microenvironment influence response to radiation therapy and the implementation of new-generation predictive radiobiologic factors in the clinic.

Author : Jeffrey Y. C. Wong
Publisher : Springer Nature
Page : 196 pages
File Size : 40,53 MB
Release : 2020-02-29
Category : Medical
ISBN : 3030386929

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This book, written by a team of international experts, concisely reviews the rationale and clinical application of image-guided total marrow irradiation, a rapidly emerging area in radiation oncology and hematopoietic cell transplantation. The aim is to provide the practicing radiation oncologist, hematologist, medical physicist, and bone marrow transplant researcher with a fundamental understanding of key aspects and an appreciation of the increasing significance of total marrow irradiation as conditioning for bone marrow transplantation. Detailed attention is paid to the impacts of recent advances in radiation therapy technology, functional PET and MRI, and understanding of the response of bone marrow to radiation. Full consideration is also given to the ways in which technological advances in image-guided radiation therapy have created new opportunities to treat bone marrow transplant patients with limited transplant options due to advanced disease, age, or co-morbidities. Further topics covered include the ways in which cancer stem cells and the marrow microenvironment influence response to radiation therapy and the implementation of new-generation predictive radiobiologic factors in the clinic.

Author : Ajay Vora
Publisher : Springer
Page : 345 pages
File Size : 43,95 MB
Release : 2017-04-21
Category : Medical
ISBN : 3319397087

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This book provides a comprehensive and up-to-date review of all aspects of childhood Acute Lymphoblastic Leukemia, from basic biology to supportive care. It offers new insights into the genetic pre-disposition to the condition and discusses how response to early therapy and its basic biology are utilized to develop new prognostic stratification systems and target therapy. Readers will learn about current treatment and outcomes, such as immunotherapy and targeted therapy approaches. Supportive care and management of the condition in resource poor countries are also discussed in detail. This is an indispensable guide for research and laboratory scientists, pediatric hematologists as well as specialist nurses involved in the care of childhood leukemia.

Author : Claudia Fuchshuber
Publisher :
Page : pages
File Size : 11,39 MB
Release : 2017
Category :
ISBN :

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Total Body Irradiation (TBI) is used in the treatment of leukemia. Total marrow irradiation (TMI) is a form of TBI that focuses the radiation to the major bone-marrow sites where the cancer cells reside. Both TBI and TMI can be performed by Volumetric Modulated Arc Therapy (VMAT). VMAT is a high-precision technique in radiotherapy, which makes it possible to reduce the dose in the lung and, if required, in other Organs At Risk (OAR). The aim of this master thesis was a comparison of VMAT-TBI and VMAT-TMI treatment technique. One major part was the analysis and comparison of the technical parameters in the planning of VMAT-TBI and VMAT-TMI with the aim to determine the main differences with regard to parameters such as number of iso-centres, field arrangement or treatment time. The second main part was an evaluation of the planned dose distributions. The quality of the Planning Target Volume (PTV) coverage in VMAT-TBI and VMAT-TMI were compared, and the effect of organ sparing was quantified. In the end, the advantages and disadvantages of VMAT-TBI and VMAT-TMI were discussed. There is not yet a distinct prove that TMI is better than TBI from a technical point of view. What remains for both techniques is a high effort on personal and time. However, TMI has its advantages with regard to the patient's benefit, especially concerning organ sparing.*****Total Body Irradiation (TBI) is used in the treatment of leukemia. Total marrow irradiation (TMI) is a form of TBI that focuses the radiation to the major bone-marrow sites where the cancer cells reside. Both TBI and TMI can be performed by Volumetric Modulated Arc Therapy (VMAT). VMAT is a high-precision technique in radiotherapy, which makes it possible to reduce the dose in the lung and, if required, in other Organs At Risk (OAR). The aim of this master thesis was a comparison of VMAT-TBI and VMAT-TMI treatment technique. One major part was the analysis and comparison of the technical parameters in the planning of VMAT-TBI and VMAT-TMI with the aim to determine the main differences with regard to parameters such as number of iso-centres, field arrangement or treatment time. The second main part was an evaluation of the planned dose distributions. The quality of the Planning Target Volume (PTV) coverage in VMAT-TBI and VMAT-TMI were compared, and the effect of organ sparing was quantified. In the end, the advantages and disadvantages of VMAT-TBI and VMAT-TMI were discussed. There is not yet a distinct prove that TMI is better than TBI from a technical point of view. What remains for both techniques is a high effort on personal and time. However, TMI has its advantages with regard to the patient's benefit, especially concerning organ sparing.

Author : Mammen Chandy
Publisher : Springer
Page : 0 pages
File Size : 42,6 MB
Release : 2021-03-25
Category : Medical
ISBN : 9783030363574

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Bone Marrow transplantation or Hematopoietic stem cell transplantation is a life saving procedure in a number of diseases,hematological and non hematological, which fail alternative medical management or have no other treatment options. It has transformed the lives of thousands of patients and their families around the world battling with fatal or debilitating diseases.There are many unique aspects of bone marrow transplantation which makes it very different from solid organ transplants. There is an enormous amount of research going on in this field both at clinical and basic science levels.With the rapidly changing world and field of transplantation, there is a need for an authoritative and up to date resource for transplant professionals. This book titled Contemporary Bone Marrow Transplantation aims to be a reference text comprehensively covering various facets of hematopoietic stem cell transplants with latest insights about the technique and basic science behind it . The book is the product of collective effort of transplant professionals round the world, and will reflect their experience as well as the current standard of care practices in Stem cell transplantation.The book will be divided into different sections focusing on the basic science of bone marrow transplant, the technical aspects of the procedure itself and the supportive care of transplant patients.There will also be a section each on epidemiology, upcoming trends and also case studies , which will discuss real case scenarios from the experience of the authors, to illustrate the practical challenges in managing bone marrow transplant recipients.

Author : Robert J. Soiffer
Publisher : Springer Science & Business Media
Page : 483 pages
File Size : 41,99 MB
Release : 2004-01-29
Category : Medical
ISBN : 1592597335

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A comprehensive survey of the current state-of-the-art in hematopoietic stem cell transplantation for malignant disease. The authors focus on the indications and results of transplantation for acute leukemia, chronic myelogenous leukemia, lymphoma, multiple myeloma, and breast cancer. Special attention is given to transplant-related complications, including the pathophysiology and clinical consequences of acute and chronic GVHD, delayed immune reconstitution leading to infectious complications, and organ damage to the lung and liver. Additional chapters address the sources of stem cells and the effects of graft manipulation used to eliminate residual contaminating tumor cells in autologous transplantation, or to reduce the number of T lymphocytes causing GVHD in allogenic transplantation.

Author : Nicolaus Kröger
Publisher :
Page : 688 pages
File Size : 45,83 MB
Release : 2020-10-08
Category : Medical
ISBN : 9781013273674

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This Open Access edition of the European Society for Blood and Marrow Transplantation (EBMT) handbook addresses the latest developments and innovations in hematopoietic stem cell transplantation and cellular therapy. Consisting of 93 chapters, it has been written by 175 leading experts in the field. Discussing all types of stem cell and bone marrow transplantation, including haplo-identical stem cell and cord blood transplantation, it also covers the indications for transplantation, the management of early and late complications as well as the new and rapidly evolving field of cellular therapies. This book provides an unparalleled description of current practices to enhance readers' knowledge and practice skills. This work was published by Saint Philip Street Press pursuant to a Creative Commons license permitting commercial use. All rights not granted by the work's license are retained by the author or authors.

Author : Michelle Kenyon
Publisher : Springer
Page : 318 pages
File Size : 37,12 MB
Release : 2018-03-14
Category : Medical
ISBN : 3319500260

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This book is open access under a CC BY 4.0 license. This textbook, endorsed by the European Society for Blood and Marrow Transplantation (EBMT), provides adult and paediatric nurses with a full and informative guide covering all aspects of transplant nursing, from basic principles to advanced concepts. It takes the reader on a journey through the history of transplant nursing, including essential and progressive elements to help nurses improve their knowledge and benefit the patient experience, as well as a comprehensive introduction to research and auditing methods. This new volume specifically intended for nurses, complements the ESH-EBMT reference title, a popular educational resource originally developed in 2003 for physicians to accompany an annual training course also serving as an educational tool in its own right. This title is designed to develop the knowledge of nurses in transplantation. It is the first book of its kind specifically targeted at nurses in this specialist field and acknowledges the valuable contribution that nursing makes in this area. This volume presents information that is essential for the education of nurses new to transplantation, while also offering a valuable resource for more experienced nurses who wish to update their knowledge.