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The selection and use of essential medicines

Author : World Health Organization
Publisher : World Health Organization
Page : 940 pages
File Size : 27,53 MB
Release : 2024-04-19
Category : Medical
ISBN : 9240089268

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The 24th meeting of the WHO Expert Committee on Selection and Use of Essential Medicines was held in Geneva, Switzerland, from 24 to 28 April 2023. The Committee considered 85 applications proposing additions, changes and deletions of medicines, medicine classes and formulations on the Model Lists of Essential Medicines. The Committee evaluated the scientific evidence for effectiveness, safety and cost- effectiveness of the medicines in question. The Committee also considered a review of the age-appropriateness of formulations of essential medicines for children, the AWaRe classification of antibiotics, and other matters relevant to the selection and use of essential medicines.

The Selection and Use of Essential Medicines

Author : WHO Expert Committee on the Selection and Use of Essential Medicines
Publisher : WHO
Page : 144 pages
File Size : 47,87 MB
Release : 2004
Category : Medical
ISBN :

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This report presents the recommendations of the WHO Expert Committee responsible for updating the WHO Model List of Essential Medicines. The first part contains a progress report on the new procedures for updating the Model List and the development of the WHO Essential Medicines Library. It continues with a section on changes made in revising the Model List followed by a review of some sections such as hypertensive medicines and fast track procedures for deleting items. Annexes include the 13th version of the Model List and items on the list sorted according to their 5-level Anatomical Therapeutic Chemical classification codes.

Antimicrobial Stewardship

Author :
Publisher : BoD – Books on Demand
Page : 230 pages
File Size : 50,2 MB
Release : 2024-06-26
Category : Medical
ISBN : 1837690901

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Over the past many years, new and novel antibiotics have been developed against resistant bacterial species, but their increased clinical usage has led to reduced bacterial susceptibility and increased bacterial resistance to these novel agents. When a new antibiotic is developed, bacterial species initially show susceptibility to the agent, but with the passage of time, as the use of the antibiotic increases, the bacterial species acquire resistance against the drug or even the drug class. This book provides a comprehensive overview of antimicrobial stewardship programs and the obstacles to implementing and maintaining such programs. Antimicrobial stewardship is an important part of a multifaceted approach to preventing the emergence of antibiotic resistance in various microbial species. The book highlights the basic and initial steps necessary for initiating an antimicrobial stewardship program, as well as explores the different strategies of antimicrobial stewardship.

Infection prevention and control in-service education and training curriculum

Author : World Health Organization
Publisher : World Health Organization
Page : 122 pages
File Size : 41,3 MB
Release : 2024-05-17
Category : Medical
ISBN : 9240094121

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The primary objective of this curriculum is to equip health and care workers with the essential knowledge and competencies necessary for delivering safe and effective care. By doing so it aims to significantly reduce HAIs and combat antimicrobial resistance, thereby safeguarding both patient and HCWs well-being. This curriculum is developed to meet the needs of IPC professionals responsible for developing learning resources and overseeing training within health care organizations. Moreover, the curriculum is intended to encompass all individuals involved in health care delivery and support. This holistic approach includes a wide range of staff -ranging from clinical workers to administrative and auxiliary services, thus ensuring a broad and inclusive approach to IPC training. The guide is designed to be flexible, allowing for adaptation to various educational and practical contexts to meet specific national and local IPC requirements and policies. It delineates three distinct competency levels within the curriculum: • foundational: introduces basic IPC principles applicable universally across all health and care worker roles; • intermediate: delivers more detailed IPC practices, particularly for clinical practitioners in direct contact with patients; • advanced: provides specialized IPC knowledge tailored for clinical specialists and managerial roles, reflecting the specific needs of their positions and settings. This curriculum serves as an essential reference tool to support the planning, development, and localization of IPC education materials, aligning closely with the WHO core components for IPC programmes and the directions provided within the WHO global strategy and action plan on IPC. It supports countries in their efforts to implement actions to improve IPC knowledge and skills among health and care workers according to the recommendations in the WHO global action plan and monitoring framework. By enhancing the IPC competencies of health and care workers, this guide supports the capacity of the health care system to effectively manage and prevent infections, which is particularly crucial in improving patient outcomes and promoting safer health care environments, including in the context of epidemics, pandemics and other public health emergencies.

WHO Expert Committee on Specifications for Pharmaceutical Preparations

Author : World Health Organization
Publisher : World Health Organization
Page : 382 pages
File Size : 20,67 MB
Release : 2024-04-26
Category : Business & Economics
ISBN : 9240091033

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The Expert Committee on Specifications for Pharmaceutical Preparations works towards clear, independent and practical standards and guidelines for the quality assurance of medicines and provision of global regulatory tools. The Expert Committee develops standards through worldwide consultation and an international consensus-building process. The following new guidance texts were adopted and recommended for use: WHO good manufacturing practices for excipients used in pharmaceutical products (revision); IAEA/WHO good manufacturing practices for in-house cold kits for radiopharmaceutical preparations (new); WHO good practices for pharmaceutical quality control laboratories (revision); WHO/UNFPA female condom generic specification (new); WHO Biowaiver List: proposal to waive in vivo bioequivalence requirements for WHO Model List of Essential Medicines immediate-release (updated), solid oral dosage forms; WHO guideline on Biopharmaceutics Classification System-based biowaivers (revision); and Multisource (generic) pharmaceutical products: guidelines on registration requirements to establish interchangeability (republished). All of the above are included in this report and recommended for implementation.

People-centred approach to addressing antimicrobial resistance in human health

Author : World Health Organization
Publisher : World Health Organization
Page : 63 pages
File Size : 20,94 MB
Release : 2023-10-19
Category : Medical
ISBN : 9240082492

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This document outlines the concept and content of the WHO people-centred approach to addressing antimicrobial resistance (AMR) in the human health sector. The proposed approach recognizes and aims to address the challenges and health system barriers people face when accessing health services to prevent, diagnose and treat (drug-resistant) infections. It puts people and their needs at the centre of the AMR response and guides policy-makers in taking programmatic and comprehensive actions to mitigate AMR in line with a proposed package of core interventions. These interventions are based on a review of four pillars and two foundational steps that are critical to overcome barriers faced by people and health systems in addressing AMR. The four pillars are: (1) prevention of infections; (2) access to essential health services; (3) timely, accurate diagnosis; and (4) appropriate, quality-assured treatment. The pillars are supported by the two foundational steps: effective governance, awareness and education; and strategic information through surveillance and research. Building and adding on to the objectives of the Global action plan on AMR, the 13 core interventions and accompanying priority actions are designed to address AMR in a programmatic manner that puts people, their needs and equitable access to health services at the centre of the AMR response in the community, in primary care, secondary and tertiary care, and at national and/or subnational level. The development of the people-centred core package of AMR interventions was based on a review of the evidence and multidisciplinary expert opinion, complemented with feedback from a global online consultation and WHO’s strategic and technical advisory group on antimicrobial resistance. As countries develop or revise their national action plans (NAPs) on AMR, the people-centred core package of interventions can support the design and prioritization of actions in the human health sector at the different levels of implementation and integrated with broader health system strengthening and pandemic preparedness and response plans.