[PDF] The Role Of Immediate Early Genes In Neuropsychiatric Illness eBook

Author : Raphael Pinaud
Publisher : Springer Science & Business Media
Page : 298 pages
File Size : 41,71 MB
Release : 2006-11-22
Category : Medical
ISBN : 0387336044

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This book provides a compilation of the most up-to-date literature on the topic of immediate early genes (IEGs). It reviews and details experiments and theories that challenge the reader to expand their view on how IEG research is currently being used to advance our understanding of static and active brain circuits. In addition, the book explores roles of IEGs in clinical neuropathology.

Author : Ales Stuchlik
Publisher : Frontiers Media SA
Page : 285 pages
File Size : 27,6 MB
Release : 2015-10-23
Category : Neurosciences
ISBN : 2889196798

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Neuropsychiatric diseases, such as schizophrenia, Alzheimer's disease, and etc., represent a serious medical and socioeconomic problems. These diseases are often accompanied by impairments of cognitive function, e.g., abstract thinking, decision-making, attention, and several types of memory. Such deficits significantly disrupt quality of life and daily functioning of patients. Cognitive deficits in neuropsychiatric diseases are associated with alterations of brain morphology and function, and are often resistant to therapeutic interventions. In schizophrenia and related disorders, cognitive deficits are also defined as endophenotypes, i.e. measurable phenotypes linking these disaeses with discrete heritable and reproducible traits. This points to the importance of elucidating these endophenotypes in translational studies. Animal models may not mimic the full spectrum of clinical symptoms, but may act as analogies of particular behaviors or other pathological outcomes. They are useful to search for the etiology of particular psychiatric illnesses and novel therapeutics. Moreover, several behavioral tests to measure cognitive performance in rodents and other species have been implemented. The primary focus of the present topic is to provide up-to-date information on cognitive deficits of neuropsychiatric disorders, such as schizophrenia. This Research Topic also delineates future directions for translational studies aimed at developing novel treatments/interventions of cognitive disturbances.

Author : Jacob Peedicayil
Publisher : Elsevier
Page : 418 pages
File Size : 21,95 MB
Release : 2023-09-29
Category : Science
ISBN : 0443185174

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Neuropsychiatric Disorders and Epigenetics, Second Edition is a comprehensive reference on the epigenetic basis of common neuropsychiatric disorders. The volume is organized into chapters covering individual neuropsychiatric disorders, from addiction to anxiety and autism spectrum disorders, and is contributed by leading experts in their respective fields. The epigenetic aspects of each disorder are discussed, in the context of the full range of associated epigenetic mechanisms, including DNA modification, histone post-translational modification, chromatin organization, and non-coding RNA. A particular emphasis is placed on potential epigenetic interventions, when the effects of environmental stimuli on epigenetic states is particularly relevant to disease. This new edition has been fully updated to reflect recent research advances enabled by genomic technologies, as well as therapeutic interventions for previously unmanageable disorders. Several new chapters have been added on disorders or approaches not considered in the earlier edition, including epigenetics and anxiety disorders, epigenetics and neuroimaging in neuropsychiatric disorders, genome-wide approaches to epigenetic research, and the epigenetics of spinal muscular atrophy. By helping to define epigenetics as a key player in neuropsychiatric disorders, this volume empowers new research, clinical translation, and pharmacological advances, and highlights promising directions for ongoing investigation. Analyzes the effects of environmental stimuli on epigenetic states that correlate with neuropsychiatric disease induction Reviews the epigenetic basis for common neuropsychiatric disorders, thereby guiding translational therapies for clinicians and mechanistic studies for scientists Features extensive use of diagrams, illustrations, tables, and graphical abstracts for each section to reinforce understanding Includes chapter contributions from leading global experts

Author : André R. Brunoni
Publisher : Springer Nature
Page : 779 pages
File Size : 27,84 MB
Release : 2021-09-20
Category : Medical
ISBN : 3030761363

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The 2nd edition of this book incorporates the tremendous clinical advances that have occurred in the field of transcranial direct current stimulation (tDCS) over the past 5 years. Since the 1st edition was published, the clinical use of tDCS has moved from its infancy, and is now in a thrilling new phase with numerous possibilities as well as challenges. tDCS is a technique that excels in terms of safety and tolerability, and within a few years, novel technological developments will allow its use at home. At the same time, large, phase III trials have been exploring the clinical efficacy of tDCS, the results of which have been published in leading journals such as the New England Journal of Medicine and JAMA Psychiatry. This 2nd edition summarizes the state of the art of the field. Written by leading experts in the field, the book is divided into 5 parts: Introduction and Mechanisms of Action; Research Methods; tDCS in the life cycle; Applications of tDCS in neuropsychiatric disorders (further divided into Psychiatry and Neurology); and The clinical use of tDCS. It also includes several new chapters, covering topics such as precision stimulation of tDCS; combination of tDCS with different neuroimaging modalities; and use of tDCS in new clinical conditions. Moreover, all chapters have been rewritten and updated. This book will be of significant interest to psychiatrists, neurologists and neuroscientists new to the field as well as those with a background in tDCS who want to increase their understanding of particular psychiatric conditions.

Author : Jacob Peedicayil
Publisher : Academic Press
Page : 848 pages
File Size : 47,55 MB
Release : 2021-08-21
Category : Science
ISBN : 0128235780

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Epigenetics in Psychiatry, Second Edition covers all major areas of psychiatry in which extensive epigenetic research has been performed, fully encompassing a diverse and maturing field, including drug addiction, bipolar disorder, epidemiology, cognitive disorders, and the uses of putative epigenetic-based psychotropic drugs. Uniquely, each chapter correlates epigenetics with relevant advances across genomics, transcriptomics, and proteomics. The book acts as a catalyst for further research in this growing area of psychiatry. This new edition has been fully revised to address recent advances in epigenetic understanding of psychiatric disorders, evoking data consortia (e.g., CommonMind, ATAC-seq), single cell analysis, and epigenome-wide association studies to empower new research. The book also examines epigenetic effects of the microbiome on psychiatric disorders, and the use of neuroimaging in studying the role of epigenetic mechanisms of gene expression. Ongoing advances in epigenetic therapy are explored in-depth. Fully revised to discuss new areas of research across neuronal stem cells, cognitive disorders, and transgenerational epigenetics in psychiatric disease Relates broad advances in psychiatric epigenetics to a modern understanding of the genome, transcriptome, and proteins Catalyzes knowledge discovery in both basic epigenetic biology and epigenetic targets for drug discovery Provides guidance in research methods and protocols, as well how to employ data from consortia, single cell analysis, and epigenome-wide association studies (EWAS) Features chapter contributions from international leaders in the field

Author : Anna Maria Giuffrida Stella
Publisher :
Page : 504 pages
File Size : 23,50 MB
Release : 1990-07-19
Category : Medical
ISBN :

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Offers an up-to-date account of the latest research findings concerned with the regulatory mechanisms of gene expression in neuronal and glial cells under different conditions. The book explores the cellular and neurobiological aspects of important phenomena of the nervous system and its role in health, disease and injury. Contributions from prominent scientists in the field address a variety of specific topics concerned with gene expression in the nervous system--from growth, hormonal and trophic factors to neural tissue reactions in injury or aging.

Author : Carl Faingold
Publisher : Academic Press
Page : 537 pages
File Size : 16,40 MB
Release : 2013-12-26
Category : Medical
ISBN : 0124158641

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Neuronal Networks in Brain Function, CNS Disorders, and Therapeutics, edited by two leaders in the field, offers a current and complete review of what we know about neural networks. How the brain accomplishes many of its more complex tasks can only be understood via study of neuronal network control and network interactions. Large networks can undergo major functional changes, resulting in substantially different brain function and affecting everything from learning to the potential for epilepsy. With chapters authored by experts in each topic, this book advances the understanding of: How the brain carries out important tasks via networks How these networks interact in normal brain function Major mechanisms that control network function The interaction of the normal networks to produce more complex behaviors How brain disorders can result from abnormal interactions How therapy of disorders can be advanced through this network approach This book will benefit neuroscience researchers and graduate students with an interest in networks, as well as clinicians in neuroscience, pharmacology, and psychiatry dealing with neurobiological disorders. Utilizes perspectives and tools from various neuroscience subdisciplines (cellular, systems, physiologic), making the volume broadly relevant Chapters explore normal network function and control mechanisms, with an eye to improving therapies for brain disorders Reflects predominant disciplinary shift from an anatomical to a functional perspective of the brain Edited work with chapters authored by leaders in the field around the globe – the broadest, most expert coverage available

Author : Theodore A. Stern
Publisher : Elsevier Health Sciences
Page : 1074 pages
File Size : 30,7 MB
Release : 2024-03-06
Category : Medical
ISBN : 0443118450

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The Massachusetts General Hospital is widely regarded as one of the world's premier psychiatric institutions. Massachusetts General Hospital Comprehensive Clinical Psychiatry, 3rd Edition, offers practical, informative, and hands-on advice from the staff of the esteemed MGH Department of Psychiatry, helping you put today’s best practices to work for your patients. This authoritative reference covers a wide variety of clinical syndromes and settings, aided by superb graphics throughout. In one convenient volume, you’ll have easy access to the answers you need to face and overcome any clinical challenge. Uses a reader-friendly and highly templated format with abundant boxed summaries, bulleted points, case histories, algorithms, references, and suggested readings. Contains new chapters on the Psychiatric Management of Patients with Cardiac, Renal, Pulmonary, and Gastrointestinal Disease; COVID-19 Infection; Burns, Trauma, and Intensive Care Unit Treatment; Care of LGBTQ Patients; and Mindfulness and Resilience. Covers key areas, such as Substance Use Disorders; Mood, Anxiety, and Psychotic Disorders; Emergency Psychiatry; Functional Neuroanatomy and the Neurologic Examination; Psychological and Neuropsychological Assessment; Military Psychiatry; Psychiatric Manifestations of Traumatic Brain Injury; Legal and Ethical Issues in Psychiatry; End of Life Care; and Approaches to Collaborative Care and Primary Care Psychiatry. Features key points for every chapter, updated DSM-5 criteria, and enhanced content on collaborative care and behavioral medicine, ensuring that your knowledge is thorough and up to date. Corresponds to the companion review volume, Massachusetts General Hospital Study Guide for Psychiatry Exams, 2nd Edition (ISBN: 978-0-443-11983-5). Any additional digital ancillary content may publish up to 6 weeks following the publication date.