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Author : Wai-man Wong (M.D., Raymond)
Publisher :
Page : 726 pages
File Size : 42,91 MB
Release : 2001
Category : Helicobacter pylori infections
ISBN :
Author :
Publisher :
Page : pages
File Size : 38,87 MB
Release : 2001
Category :
ISBN :
(Uncorrected OCR) Abstract of thesis entitled The Pathology, Diagnosis and Treatment of Helicobacter pylori Infection Submitted by Wong Wai Man, Raymond for the degree of Doctor of Medicine at The University of Hong Kong in July 2001 The aims of this thesis were 1) to study Helicobacter pylori (H. pylori) related mucosal pathology; 2) to evaluate the best diagnostic test for H. pylori; and 3) to test the efficacy of 3 different therapies for H. pylori infection. Pseudopyloric metaplasia represents a metaplasia of the pyloric glands and is closely associated with hyperplasia of the mucous neck cells (MNC). Both MNC hyperplasia and pseudopyloric metaplasia were associated with H. pylori gastritis. This lineage expressed TFF2, MUC6, PSTI and lysozyme. Ulcerative associated cell lineage was seen to arise from pre-existing crypts in areas of intestinal metaplasia, and plays no part in the histogenesis of pseudopyloric metaplasia. Intestinal metaplasia, which is a H. pylori related pre-malignant lesion of the gastric mucosa, showed evidence of cell cycle de- regulation in the goblet and Paneth cell lineages but not in endocrine cell lineage, which have considerable implications for the biology of intestinal metaplasia. Helicobacter pylori infection can be diagnosed by invasive and noninvasive tests. Five invasive tests and one non- invasive test were evaluated. For routine clinical use, histology, rapid urease test and 13C_ Urea breath test (13C_ UBT) had an accuracy of 100%, 99.7%and 94.5% respectively. For research purposes, the accuracy of two positives out of three diagnostic tests was equally reliable. A new rapid urease test, the PyloriTek test was evaluated for the diagnosis of H. pylori infection before and after eradication therapy. It is highly accurate and one biopsy from the antrum was reliable. A simplified 75gm 13C_ UBT was evaluated in Chinese population. The optimal delta-value and optimal measurement interval for UBT were 5%0 and 30 minutes respectively.
Author : Jose M. Pajares
Publisher : Springer Science & Business Media
Page : 401 pages
File Size : 36,84 MB
Release : 2012-12-06
Category : Medical
ISBN : 3642774865
In the rapidly evolving field of Helicobacter infection new data on pathogenetic and pathophysiological mechanism have appeared. New methods which will be more sensitive and specific in the diagnosis of the infection are being developed and in this proceedings the first attempt using PCR technology is published. From the clinical point of view, a challenging aspect that needs clarification, is the observation which suggests an appearance of a correlation between the presence of the bacteria and abdominal pain and other symptoms in children whereas in old age no such correlation is evident. The relationship of H. pylori and gastric cancer is studied with histopathological data and epidemiological approaches. On the treatment side schemes using short courses and new antibiotic combinations are being investigated and preliminary data are reported.
Author : Hidekazu Suzuki
Publisher : Springer
Page : 265 pages
File Size : 26,50 MB
Release : 2016-04-13
Category : Medical
ISBN : 4431557059
This book provides a detailed review of the most recent pathogenetic, diagnostic and therapeutic approaches in connection with Helicobacter pylori, along with priority areas in research and trends in clinical practice to address this significant pathogen acknowledged as the causative agent in a wide range of diseases, including gastric adenocarcinoma, MALT lymphoma and immune thrombocytopenic purpura (ITP). Medical authorities worldwide now recommend a “test and treat” strategy for this bacterial infection. Eradication therapy approaches range from general mass eradication therapy to tailor-made therapy for antibiotic-resistant refractory infection. In regions with high prevalence of H. pylori infection, the infection itself would be considered a major parameter to predict the risk of gastric adenocarcinoma development. The main interest has shifted recently to the risk stratification strategy for gastric cancer development and to the wide-ranging application of its serological prevention program. This book will benefit all gastroenterologists, hematologists, dermatologists, primary care doctors, epidemiologists, physicians who related with community hygiene, as well as basic scientists, particularly microbiologists, bacteriologists, pathologists, molecular biologists, biochemists, immunologists and oncologists.
Author : Jose M. Pajares
Publisher : Springer
Page : 400 pages
File Size : 22,97 MB
Release : 1993-04-02
Category : Medical
ISBN : 9783540554325
In the rapidly evolving field of Helicobacter infection new data on pathogenetic and pathophysiological mechanism have appeared. New methods which will be more sensitive and specific in the diagnosis of the infection are being developed and in this proceedings the first attempt using PCR technology is published. From the clinical point of view, a challenging aspect that needs clarification, is the observation which suggests an appearance of a correlation between the presence of the bacteria and abdominal pain and other symptoms in children whereas in old age no such correlation is evident. The relationship of H. pylori and gastric cancer is studied with histopathological data and epidemiological approaches. On the treatment side schemes using short courses and new antibiotic combinations are being investigated and preliminary data are reported.
Author : David Schlossberg
Publisher : Cambridge University Press
Page : 1509 pages
File Size : 34,91 MB
Release : 2015-04-23
Category : Medical
ISBN : 110703891X
A clinically oriented, user-friendly text on the diagnosis and treatment of infectious diseases for practising clinicians, students and residents.
Author : Giovanni Gasbarrini
Publisher : Springer Science & Business Media
Page : 333 pages
File Size : 35,64 MB
Release : 2012-12-06
Category : Medical
ISBN : 3642782310
A century ago the Italian pathologist Bizzozero described the relationships between spiral bacteria and the mammalian gastro intestinal tract. Since 1982, when Helicobacter pylori was discovered, gastroduodenal disease have been completely revised as a con sequence of the results of basic and clinical research in this field. Progress in understanding the pathogenesis of this bacterium has been made by studying H. pylori infection in animal models. More specific diagnostic tools have been developed using new molecular biology techniques. Future trends are directed towards preparing a specific H. pylori vaccine. A new classification for gastritis, the Sydney System, including H. pylori gastritis, was proposed in 1990. As concerns the clinical approach to peptic ulcer disease in the 1990's, the majority of authors agree on the importance of H. pylori eradication. Moreover, recent clinical studies suggest that H. pylori infection can be associated with other gastroduodenal diseases, such as non ulcer dyspepsia and gastric cancer. Multicenter trials to standardize serological methods and evaluate the efficacy of new antimicrobial therapy schedules are planned throughout different European countries. The fourth Workshop of the European Helicobacter Pylori Study Group was held in Bologna, Italy, in November 1991. Two years before Bologna University celebrated its ninth centennial, giving evidence of being the oldest University in the modern world. Thus the H. pylori story that has continued for more than a century has been discussed once again at the University with the oldest tradition in the world.
Author : Vincenzo Canzonieri
Publisher : Springer
Page : 256 pages
File Size : 31,2 MB
Release : 2019-05-02
Category : Medical
ISBN : 3030048616
Gastric cancer is one of the most common and potentially lethal gastrointestinal malignancy, but it is now at the forefront of modern oncology due to new discoveries. In recent years, the field of gastric cancer has been transformed by many notable developments in both the diagnostic area and the therapeutic strategies. The main aim of the text is to propose a comprehensive, state-of-the art review of this field, and will serve as a valuable resource for oncologists, pathologists, surgeons and researchers with an interest in gastric cancer. The first chapters will review the interplay between pathogens and especially H. pylori, inflammation, genomic instability, and tumorigenesis. Secondly, an exhaustive overview of the diagnosis of gastric cancer from a clinical/endoscopic and pathologic perspectives will be illustrated. Two specific chapters will deal with tissue and serum biomarkers with an important role in diagnosis as well as prognostic and predictive markers of response to specific therapy. A central section of the book will focus on treatment options available today for patients. Surgery is the cornerstone of treatment for gastric cancer; however, the prognosis of patients with locally advanced disease is still poor even after curative resection. Therefore, in order to improve the prognosis of patients, especially with advanced stage, a multimodal strategy is advisable and is thoroughly addressed in the appropriate section. With the advent of next-generation sequencing and new preclinical model technologies, the genomic landscape of gastric cancer has been delineated and molecular characterizations finalized to novel therapeutic targets of each molecular subtype have been identified. These advances are making it feasible to integrate clinical and phenotype-based diagnostic and therapeutic methods and are described in a dedicated section. The text will conclude with chapters focusing on the future direction of gastric cancer research in the precision medicine era: an in-depth analysis of non-coding RNAs and their role in gastric cancer, the impact of immunomodulation/immunotherapy and the perspectives of nano-medicine will be finally proposed to the audience. A brief review of the existing literature addressing the above mentioned topics will be present in each chapter. This text will serve as a useful resource for physicians and researchers dealing with, and interested in, this challenging malignancy. It will provide a concise yet comprehensive summary of the current status of the field that will help guide patient management and stimulate investigative efforts. All chapters will be written by experts in their fields and will include the most up to date scientific and clinical information.
Author : Shigeru Kamiya
Publisher : Springer Nature
Page : 284 pages
File Size : 50,19 MB
Release : 2019-10-22
Category : Medical
ISBN : 303021916X
This book gathers a wealth of contributions on the virulence factors and pathogenic mechanism of Helicobacter pylori, prepared by leading international experts. In addition, it explores the epidemiology, diagnosis, treatment with drugs and probiotics, and prophylaxis by vaccination, reflecting the latest advances. H. pylori is a Gram negative microaerophilic bacterium that can produce various gastric diseases including gastritis, gastroduodenal ulceration, gastric cancer and gastric MALT lymphoma. Although efforts to combat H. pylori using a combination of proton pump inhibitor and several antimicrobial drugs have significantly decreased the burden of these gastric diseases, the microbial epidemiology and gastric pathogenesis following H. pylori infection are still not fully understood. Given its scope, the book offers a valuable resource not only for basic microbiologists, but also for researchers in the fields of pathology, biochemistry and genomics, as well as medical students/scientists.
Author : Buzás György Miklós
Publisher : Bentham Science Publishers
Page : 526 pages
File Size : 27,48 MB
Release : 2014-03-12
Category : Medical
ISBN : 1608057372
This e-book covers Helicobacter pylori research as it looks in 2014. The discovery of the bacterium in 1982 by B.J. Marshall and R. I. Warren had a tremendous impact on basic research and clinical medicine, resulting, in the past 3 decades, in more than 34,000 published articles. The editor of this volume and the contributing authors have compiled a unique collection of chapters dealing the with the microbiology, epidemiology, clinical diagnosis and treatment of H. pylori infections in a country-specific manner, with contributors having the opportunity to present the peculiarities and specifics of Helicobacter research in their area or country without overlapping any other previously published e-book. This e-book is a useful reference for gastrointestinal physicians and medical researchers seeking the latest information related to H. pylori.