Author : Patrick Schnider
Publisher : Royal Society of Chemistry
Page : 541 pages
File Size : 32,35 MB
Release : 2021-08-27
Category : Science
ISBN : 1788012275
Medicinal chemistry is a complex science that lies at the very heart of drug discovery. Poor solubility, complex metabolism, tissue retention and slow elimination are just some of the properties of investigational compounds that present a challenge to the design and conduct of ADMET studies. Medicinal chemistry experience and knowledge relating to how a lead structure was modified to solve a specific problem is generally very challenging to retrieve. Presented in a visual and accessible style, this book provides rapid solutions to overcome the universal challenges to optimizing ADMET.