[PDF] The Ingenuity Of Genes eBook

Author : Roger Sansom
Publisher : MIT Press
Page : 141 pages
File Size : 21,88 MB
Release : 2011-09-30
Category : Science
ISBN : 0262297264

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A proposal for a new model of the evolution of gene regulation networks and development that draws on work from artificial intelligence and philosophy of mind. Each of us is a collection of more than ten trillion cells, busy performing tasks crucial to our continued existence. Gene regulation networks, consisting of a subset of genes called transcription factors, control cellular activity, producing the right gene activities for the many situations that the multiplicity of cells in our bodies face. Genes working together make up a truly ingenious system. In this book, Roger Sansom investigates how gene regulation works and how such a refined but simple system evolved. Sansom describes in detail two frameworks for understanding gene regulation. The first, developed by the theoretical biologist Stuart Kauffman, holds that gene regulation networks are fundamentally systems that repeat patterns of gene expression. Sansom finds Kauffman's framework an inadequate explanation for how cells overcome the difficulty of development. Sansom proposes an alternative: the connectionist framework. Drawing on work from artificial intelligence and philosophy of mind, he argues that the key lies in how multiple transcription factors combine to regulate a single gene, acting in a way that is qualitatively consistent. This allows the expression of genes to be finely tuned to the variable microenvironments of cells. Because of the nature of both development and its evolution, we can gain insight into the developmental process when we identify gene regulation networks as the controllers of development. The ingenuity of genes is explained by how gene regulation networks evolve to control development.

Author :
Publisher :
Page : 678 pages
File Size : 32,64 MB
Release : 2004
Category : Genetic engineering
ISBN :

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Report of an inquiry concerned with two broad issues: the patenting of genetic materials and technologies, and the exploitation of these patents and the distinction that can and possibly should be made between discoveries and inventions when referring to claims over genetic sequences.

Author : Australia. Law Reform Commission
Publisher : Virago Press
Page : 690 pages
File Size : 33,92 MB
Release : 2004
Category : Genes
ISBN :

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Report of an inquiry concerned with two broad issues: the patenting of genetic materials and technologies, and the exploitation of these patents and the distinction that can and possibly should be made between discoveries and inventions when referring to claims over genetic sequences.

Author : Nessa Carey
Publisher : Icon Books
Page : 112 pages
File Size : 11,5 MB
Release : 2019-03-07
Category : Science
ISBN : 1785784986

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'An excellent, brisk guide to what is likely to happen as opposed to the fantastically remote.' - Los Angeles Review of Books In 2018 the world woke up to gene editing with a storm of controversy over twin girls born in China with genetic changes deliberately introduced by scientists - changes they will pass on to their own offspring. Genetic modification (GM) has been with us for 45 years now, but the new system known as CRISPR or gene editing can manipulate the genes of almost any organism with a degree of precision, ease and speed that we could only dream of ten years ago. But is it ethical to change the genetic material of organisms in a way that might be passed on to future generations? If a person is suffering from a lethal genetic disease, is it unethical to deny them this option? Who controls the application of this technology, when it makes 'biohacking' - perhaps of one's own genome - a real possibility? Nessa Carey's book is a thrilling and timely snapshot of a cutting-edge technology that will radically alter our futures and the way we prevent disease. 'A focused snapshot of a brave new world.' - Nature 'A brisk, accessible primer on the fast-moving field, a clear-eyed look at a technology that is already driving major scientific advances - and raising complex ethical questions.' - Emily Anthes, Undark

Author : Derek Harvey
Publisher : Firefly Books
Page : 192 pages
File Size : 16,88 MB
Release : 2019-02-15
Category : Science
ISBN : 9780228101758

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An illustrated introduction to genetics. The Secret Life of Genes is the story of genetic science and how it makes each of us unique. It spans the discovery of the gene and the all-encompassing role it plays in biology: from controlling the inner workings of cells and the development of embryos, through patterns of inheritance, to the evolution of new forms of life. From there developed the vast and boundless field of genetic science and research. Readers will get a sneak peek into the Human Genome Project, the international scientific research project with the goal of determining the sequence of nucleotide base pairs that make up human DNA. From this, scientists identified and mapped all of the genes of the human genome from both a physical and a functional standpoint, and opened a Pandora's box of secrets: the hidden workings of the human genome; how gene switching, junk DNA, and genetic mutation might be affecting our everyday lives; and why patents are soaring for genetic inventions. The Secret Life of Genes is written in accessible language and organized for easy comprehension. It opens with the basics and the key theories, goes on to describe DNA sequencing and what we can do with it. It then looks at the history of the world's DNA and gives readers an exciting glimpse of the future of the field.

Author : Dalton Conley
Publisher : Princeton University Press
Page : 294 pages
File Size : 17,12 MB
Release : 2018-11-13
Category : Science
ISBN : 0691183163

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"For a century, social scientists have avoided genetics like the plague. But in the past decade, a small but intrepid group of economists, political scientists, and sociologists have harnessed the genomics revolution to paint a more complete picture of human social life than ever before. The Genome Factor describes the latest astonishing discoveries being made at the scientific frontier where genomics and the social sciences intersect. The Genome Factor reveals that there are real genetic differences by racial ancestry--but ones that don't conform to what we call black, white, or Latino. Genes explain a significant share of who gets ahead in society and who does not, but instead of giving rise to a genotocracy, genes often act as engines of mobility that counter social disadvantage. An increasing number of us are marrying partners with similar education levels as ourselves, but genetically speaking, humans are mixing it up more than ever before with respect to mating and reproduction. These are just a few of the many findings presented in this illuminating and entertaining book, which also tackles controversial topics such as genetically personalized education and the future of reproduction in a world where more and more of us are taking advantage of cheap genotyping services like 23andMe to find out what our genes may hold in store for ourselves and our children. The Genome Factor shows how genomics is transforming the social sciences--and how social scientists are integrating both nature and nurture into a unified, comprehensive understanding of human behavior at both the individual and society-wide levels."--

Author : Michel Morange
Publisher : Harvard University Press
Page : 256 pages
File Size : 23,23 MB
Release : 2001
Category : Science
ISBN : 9780674003361

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At a time when the complete human genome has been sequenced and when seemingly every week feature news stories describe genes that may be responsible for personality, intelligence, even happiness, Michel Morange gives us a book that demystifies the power of modern genetics. The Misunderstood Gene takes us on an easily comprehensible tour of the most recent findings in molecular biology to show us how--and if--genes contribute to biological processes and complex human behaviors. As Morange explains, if molecular biologists had to designate one category of molecules as essential to life, it would be proteins and their multiple functions, not DNA and genes. Genes are the centerpiece of modern biology because they can be modified. But they are only the memory that life invented so that proteins could be efficiently reproduced. Morange shows us that there is far more richness and meaning in the structure and interactions of proteins than in all the theoretical speculations on the role of genes. The Misunderstood Gene makes it clear that we do not have to choose between rigid genetic determinism and fearful rejection of any specific role for genes in development or behavior. Both are true, but at different levels of organization. Morange agrees with those who say "we are not in our genes." But he also wants us to understand that we are not without our genes, either. We are going to have to make do with them, and this book will show us how.

Author : Siddhartha Mukherjee
Publisher : Simon and Schuster
Page : 624 pages
File Size : 11,48 MB
Release : 2016-05-17
Category : Medical
ISBN : 1476733538

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The #1 NEW YORK TIMES Bestseller The basis for the PBS Ken Burns Documentary The Gene: An Intimate History Now includes an excerpt from Siddhartha Mukherjee’s new book Song of the Cell! From the Pulitzer Prize–winning author of The Emperor of All Maladies—a fascinating history of the gene and “a magisterial account of how human minds have laboriously, ingeniously picked apart what makes us tick” (Elle). “Sid Mukherjee has the uncanny ability to bring together science, history, and the future in a way that is understandable and riveting, guiding us through both time and the mystery of life itself.” —Ken Burns “Dr. Siddhartha Mukherjee dazzled readers with his Pulitzer Prize-winning The Emperor of All Maladies in 2010. That achievement was evidently just a warm-up for his virtuoso performance in The Gene: An Intimate History, in which he braids science, history, and memoir into an epic with all the range and biblical thunder of Paradise Lost” (The New York Times). In this biography Mukherjee brings to life the quest to understand human heredity and its surprising influence on our lives, personalities, identities, fates, and choices. “Mukherjee expresses abstract intellectual ideas through emotional stories…[and] swaddles his medical rigor with rhapsodic tenderness, surprising vulnerability, and occasional flashes of pure poetry” (The Washington Post). Throughout, the story of Mukherjee’s own family—with its tragic and bewildering history of mental illness—reminds us of the questions that hang over our ability to translate the science of genetics from the laboratory to the real world. In riveting and dramatic prose, he describes the centuries of research and experimentation—from Aristotle and Pythagoras to Mendel and Darwin, from Boveri and Morgan to Crick, Watson and Franklin, all the way through the revolutionary twenty-first century innovators who mapped the human genome. “A fascinating and often sobering history of how humans came to understand the roles of genes in making us who we are—and what our manipulation of those genes might mean for our future” (Milwaukee Journal-Sentinel), The Gene is the revelatory and magisterial history of a scientific idea coming to life, the most crucial science of our time, intimately explained by a master. “The Gene is a book we all should read” (USA TODAY).

Author : Frederick Sanger
Publisher : World Scientific
Page : 680 pages
File Size : 17,76 MB
Release : 1996
Category : Science
ISBN : 9789810224301

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This important volume is mainly concerned with the development of methods for ?sequencing? ? that is, determination of the order of the amino acids in proteins and of nucleotides in RNA and DNA. In 1943 the position of only one amino acid in a protein (insulin) was known, and Sanger's first paper resulted in finding a second amino acid. In his final paper in 1982 he describes the determination of a DNA sequence of 48,502 nucleotides. The papers describe the steady improvements in techniques, and exciting biological results revealed by the sequences.