[PDF] The Discovery Of New And Exciting Transition Metal Catalysts For Selective Hydroboration Reactions eBook

Author : Matthew L. Crawley
Publisher : John Wiley & Sons
Page : 386 pages
File Size : 22,70 MB
Release : 2012-07-03
Category : Science
ISBN : 0470631325

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This book focuses on the drug discovery and development applications of transition metal catalyzed processes, which can efficiently create preclinical and clinical drug candidates as well as marketed drugs. The authors pay particular attention to the challenges of transitioning academically-developed reactions into scalable industrial processes. Additionally, the book lays the groundwork for how continued development of transition metal catalyzed processes can deliver new drug candidates. This work provides a unique perspective on the applications of transition metal catalysis in drug discovery and development – it is a guide, a historical prospective, a practical compendium, and a source of future direction for the field.

Author : Jiro Tsuji
Publisher : John Wiley & Sons
Page : 500 pages
File Size : 23,81 MB
Release : 2002-08-16
Category : Science
ISBN : 9780471560272

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Im Laufe der vergangenen 35 Jahre wurden unzahlige Synthesewege entwickelt, bei denen Ubergangsmetallkomplexe entweder als Reagenzien oder als Katalysatoren fungieren. Dieses Buch bietet besonders denjenigen Synthesechemikern interessante und moderne Einblicke, die bisher noch nicht mit den vielfaltigen Moglichkeiten der Organometallchemie mit Ubergangsmetallen vertraut sind. Zu wichtigen ubergangsmetallkatalysierten Reaktionen werden Anwendungsbeispiele diskutiert. (01/00)

Author : Christian Hess
Publisher : Nanoscience & Nanotechnology Series
Page : 438 pages
File Size : 17,31 MB
Release : 2011
Category : Science
ISBN : 9780854041862

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The book gives a comprehensive summary of the existing information on the structural/electronic properties, chemistry and catalytic properties of vanadium and molybdenum containing catalysts. As at least one of these two elements is essential to most partial oxidation catalysts the book is of great interest to advanced students of catalysis and researchers both in academia and industry. Despite major developments in the field, the last book with a similar scope was published in 1989 and therefore a new book is overdue. The book benefits largely from the fact that the subject is a major research focus at the Department of Inorganic Chemistry amongst other departments at the Fritz Haber Institute, a world leading institution for catalysis research, ensuring an up-to-date treatise. Such an integrated approach including the relation of in situ spectroscopic results from real catalysts to those of model catalytic systems has not been accomplished before. The introductory chapter discusses the importance of nanoscience for the controlled synthesis of catalysts with functional properties. The following two chapters introduce the necessary background regarding surface properties and preparation techniques, leading from a textbook level to the current state of knowledge. The following chapter starts with an extensive survey and analysis of the existing open and patent literature, which is an essential knowledge source for the development of the new generation of partial oxidation catalysts and will be of particular value to those developing new partial oxidation catalysts. In the remaining subchapters, important examples from current research on partial oxidation reactions are reviewed from experts in the field. The next chapter discusses the importance of 2- and 3-dimensional model systems for a fundamental understanding of the structure of transition metal oxide catalysts and its correlation to reactivity. These results are related to those of the real catalytic systems. The last chapter gives an outlook on research opportunities within the area of partial oxidation reactions.

Author : Christopher Masters
Publisher : Springer
Page : 298 pages
File Size : 35,97 MB
Release : 1981
Category : Juvenile Nonfiction
ISBN :

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Soluble catalysts are used extensively in many branches of chemistry and are indeed a vital constituent of many natural processes. They find wide application throughout the chemical industry where they assist in the production of several million tonnes of chemicals each year. Since homogeneous systems, especially those incorporating transition metals, often function effectively under milder conditions than their heterogeneous counterparts, they are becoming increasingly important at a time when the chemical industry in particular, and society in general, is seeking ways of conserving energy and of making the best possible use of available resources. My principal objective in· writing this book is to engender sufficient enthusiasm for, and knowledge of, the subject in the reader that he or she will be encouraged to begin, or continue, to make their own contribution to advancing our knowledge of homogeneous catalysis. After attempting to acquaint the reader with some of the ground rules I have tried to describe the .present scope, and the future potential, of this fascinating field of chemistry by drawing both on academic and on industrial data sources. This approach stems from a personal conviction that future progress could be considerably hastened by a more meaningful dialogue between chemists working both in industrial and in academic research institutions. Wherever possible, examples of the commercial application of homogeneous catalyst systems have been included and no attempt has been made in any way to disguise the many unresolved questions and exciting challenges which still pervade this rapidly developing area.

Author : Silvia Diez-Gonzalez
Publisher : Royal Society of Chemistry
Page : 637 pages
File Size : 41,88 MB
Release : 2016-11-04
Category : Science
ISBN : 1782626816

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In less than 20 years N-heterocyclic carbenes (NHCs) have become well-established ancillary ligands for the preparation of transition metal-based catalysts. This is mainly due to the fact that NHCs tend to bind strongly to metal centres, avoiding the need of excess ligand in catalytic reactions. Also, NHC‒metal complexes are often insensitive to air and moisture, and have proven remarkably resistant to oxidation. This book showcases the wide variety of applications of NHCs in different chemistry fields beyond being simple phosphine mimics. This second edition has been updated throughout, and now includes a new chapter on NHC‒main group element complexes. It covers the synthesis of NHC ligands and their corresponding metal complexes, as well as their bonding and stereoelectronic properties and applications in catalysis. This is complemented by related topics such as organocatalysis and biologically active complexes. Written for organic and inorganic chemists, this book is ideal for postgraduates, researchers and industrialists.

Author : Minsoo Ju
Publisher :
Page : 526 pages
File Size : 44,34 MB
Release : 2020
Category :
ISBN :

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The development of selective C-N bond forming reactions represents an important research area because amines are prevalent in biologically active natural products, pharmaceuticals, agrochemicals, and ligands. Traditionally, the reactivity and selectivity of amine-forming reactions had a strong dependence on pre-functionalized starting materials which resulted in costly chemical steps. More direct C-H amination or C=C bond aziridination reactions via transition metal-catalyzed nitrene transfer have been brought to the synthetic community's attention recently for their potential to efficiently form valuable C-N bonds. Unfortunately, the development of efficient NT methods has been met with several challenges including substrate-dependent selectivity and the need for costly transition metal catalysts. The work described herein represents a new approach to these reactions in which rationally designed silver catalysts are utilized to achieve high chemo-, regio- and ultimately, enantioselectivity in a catalyst-controlled manner. Chapter 1 serves as an introduction by providing a selected review of literature on recent asymmetric metal-catalyzed nitrene transfer reactions emphasizing the common catalyst design strategies to solve problems associated with selectivity and reactivity. Chapter 2 describes a method for chemo- and enantioselective silver-catalyzed nitrene transfer in which homoallylic carbamates are transformed into [4.1.0]-carbamate-tethered aziridines in good yields and enantiomeric excess (ee) via intramolecular aziridination. The aziridine products undergo nucleophilic ring-opening to yield enantioenriched amines with no erosion in stereochemical integrity. Chapter 3 presents two complementary silver catalysts that are capable of selecting between [Beta] or [gamma] C(sp3)-H bonds residing in similar steric/electronic environments, overriding reaction at a weaker C-H bond in favor of a stronger one, and activating primary C-H bonds. Further experimental and computational studies revealed some mechanistic insights into this system and what seems to be causing this interesting catalyst-controlled regioselectivity. Finally, Chapter 4 offers an extension of the regioselective silver-catalyzed NT, where [gamma]-propargylic-[gamma]-amino alcohol motifs are synthesized with high site- and enantioselectivity. The protocol was enabled by a new optically active bis(oxazoline) ligand designed via a rapid structure-activity relationship analysis.