[PDF] The Developmental Road Of A Dopamine Neuron eBook

Author : Jeroen Pasterkamp
Publisher : Springer Science & Business Media
Page : 143 pages
File Size : 19,59 MB
Release : 2009-12-16
Category : Medical
ISBN : 1441903224

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Theneurotransmitter dopamine has just celebrated its 50thbirthday. The discovery of dopamine as a neuronal entity in the late 1950s and the notion that it serves in neurotransmission has been a milestone in the field of neuroscience research. This milestone marked the beginning of an era that explored the brain as an integrated collection of neuronal systems that one could distinguish on basis of neurotransm- ter identities, and importantly, in which one started to be able to pinpoint the seat of brain disease. The mesodiencephalic dopaminergic (mdDA) system, previously designated as midbraindopaminergic system, has received much attention since its discovery. The initial identification of dopamine as a neurotransmitter in the central nervous system (CNS) and its relevance to psychiatric and neurological disorders have stimulated a plethora of neurochemical, pharmacological and genetic studies into the function of dopamine neurons and theirprojections. In the last decade, studies on gene expression and development have further increased the knowledge of this neuronal population and have unmasked a new level of complexity. The start of the molecular dissection of the mdDA system has been marked by the cloning and characterization ofNurrl and Pitx3. These transcription factors were shown to have a critical function during mdDA development. These initial studies have been followed by the identification of many other proteins, which have a crucial function in the creation of a dopamine neuron permissive region, induction of precursors, induction of terminaldifferent- tion and finally maintenance of the mdDA neuronal pool.

Author : Leslie L. Iversen
Publisher :
Page : 632 pages
File Size : 28,84 MB
Release : 2010
Category : Medical
ISBN : 0195373030

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The discovery of dopamine in 1957-1958 was one of the seminal events in the development of modern neuroscience, and has been extremely important for the development of modern therapies of neurological and psychiatric disorders. Dopamine has a fundamental role in almost all aspects of behavior: from motor control to mood regulation, cognition and addiction and reward, and dopamine research has been unique within the neurosciences in the way it has bridged basic science and clinical practice. Over the decades research into the role of dopamine in health and disease has been in the forefront of modern neuroscience. The Dopamine Handbook is the first single-volume publication to capture current progress and excitement in this dynamic research field.

Author : Leslie Iversen
Publisher : Oxford University Press
Page : pages
File Size : 30,82 MB
Release : 2009-11-13
Category : Medical
ISBN : 0199706611

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The discovery of dopamine in 1957-1958 was one of the seminal events in the development of modern neuroscience, and has been extremely important for the development of modern therapies of neurological and psychiatric disorders. Dopamine has a fundamental role in almost all aspects of behavior: from motor control to mood regulation, cognition and addiction and reward, and dopamine research has been unique within the neurosciences in the way it has bridged basic science and clinical practice. Over the decades research into the role of dopamine in health and disease has been in the forefront of modern neuroscience. The Dopamine Handbook is the first single-volume publication to capture current progress and excitement in this dynamic research field.

Author : Tippabathani Jayakrishna S
Publisher : Independent Author
Page : 0 pages
File Size : 27,82 MB
Release : 2023-03-19
Category : Education
ISBN : 9781805251316

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Dopamine (DA) is involved in many metabolic and regulating functions such as reward, motivation, memory, attention, and regulating body movements. In the mammalian central nervous system (CNS), mesencephalic dopaminergic (mDA) neurons are the main source of dopamine (Holzschuh et al., 2001). The selective loss of mDA neurons of the substantia nigra pars compacta (SNpc) is the hallmark of Parkinson's disease (PD) (DeMaagd and Philip, 2015). PD is associated with impairment of cognitive capabilities and symptoms like bradykinesia, tremor, and akinesia. Scientific reports are working to decipher the cellular and molecular mechanisms driving PD pathogenesis, as it is not well understood. Symptoms manifest only after 70-80% of mDA neurons have been degenerated (Cheng et al., 2010) and may be devastating because the adult CNS has extremely limited intrinsic regeneration to replace the lost neurons (Horner and Gage, 2000). Unfortunately, the loss of DA neurons cannot be rescued or reversed by drug administration. It is mandatory to decipher the neurogenesis and their mechanism, as they assist the scientific community towards inducing human stem cells to express a dopaminergic phenotype.

Author :
Publisher : Elsevier
Page : 320 pages
File Size : 32,19 MB
Release : 2014-06-23
Category : Science
ISBN : 0444634274

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Progress in Brain Research is a well-established international series examining major areas of basic and clinical research within neuroscience, as well as emerging and promising subfields. This volume, concentrates on state-of-the-art of dopamine research: from basic science to clinical applications. It covers topics including thalamostriatal synapses as a substrate for dopamine action; the multilingual nature of dopamine neurons; ethanol-mechanisms along the mesolimbic dopamine system, and much more.Progress in Brain Research is the most acclaimed and accomplished series in neuroscience, firmly established as an extensive documentation of the advances in contemporary brain research. The volumes, some of which are derived from important international symposia, contain authoritative reviews and original articles by invited specialists. The rigorous editing of the volumes assures that they will appeal to all laboratory and clinical brain research workers in the various disciplines: neuroanatomy, neurophysiology, neuropharmacology, neuroendocrinology, neuropathology, basic neurology, biological psychiatry, and the behavioral sciences. The most acclaimed and accomplished series in neuroscience This volume looks at dopamine research in the light of the newest scholarly discoveries and insights

Author : Gaetano Di Chiara
Publisher : Springer Science & Business Media
Page : 355 pages
File Size : 18,17 MB
Release : 2012-12-06
Category : Medical
ISBN : 3642560512

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With contributions by numerous experts