[PDF] The Development Of The Human Trophoblast eBook

Author : Yuping Wang
Publisher : Biota Publishing
Page : 126 pages
File Size : 17,47 MB
Release : 2017-06-23
Category : Medical
ISBN : 1615047514

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The placenta is an organ that connects the developing fetus to the uterine wall, thereby allowing nutrient uptake, waste elimination, and gas exchange via the mother's blood supply. Proper vascular development in the placenta is fundamental to ensuring a healthy fetus and successful pregnancy. This book provides an up-to-date summary and synthesis of knowledge regarding placental vascular biology and discusses the relevance of this vascular bed to the functions of the human placenta.

Author : Alberto Rossi
Publisher :
Page : 101 pages
File Size : 48,63 MB
Release : 2015
Category : Trophoblast
ISBN : 9781634823203

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Trophoblasts (from Greek trephein: to feed, and blastos: germinator) constitute a particular population of cells forming the outer layer of the blastocyst, providing the embryo with nutrients and giving rise to the outer chorionic sac and the fetal component of the placenta. The trophoblast facilitates embryonic implantation via its inner layer of mononuclear cytotrophoblasts and its outer layer of multinuclear cytoplasm, the syncytiotrophoblasts, forming the early connections between the embryo and the maternal endometrium. The cells of the trophoblast have many qualities, exhibit important functions and have an important role in the development of the placenta; also, they work as a regulator during early growth of the embryo. This volume provides a detailed summary of knowledge regarding the development of the trophoblast during the First Trimester of Pregnancy, the process of placenta apoptosis and the factors causing aging of the placenta. The pathology of trophoblast can manifest itself in several clinical conditions during pregnancy such as intrauterine fetal growth restriction (IUGR), gestational trophoblastic disease and pre-eclampsia. The analysis of the pathogenetic mechanisms involved in these critical conditions are discussed in this book. These aspects are analyzed with scientific methodology on the basis of updated studies. Development of Human Trophoblast can be considered a reference book for every pathologist, obstetrician and resident.

Author : Ashley Moffett
Publisher : Cambridge University Press
Page : 246 pages
File Size : 17,64 MB
Release : 2011-08-18
Category : Medical
ISBN : 1139452541

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Originally published in 2006, this book provides an in-depth account of trophoblast: the tissue derived from the fertilised egg that nourishes and protects the developing fetus. The cells of the trophoblast have many unique qualities, and exhibit great variability across different species. It has a fascinating role in the development of the placenta and as a regulator during early growth of the embryo. These aspects are all fully covered as well as studies on why it is not rejected by the mother as 'foreign' tissue. Disorders of trophoblast during development also manifest themselves in several clinical conditions during pregnancy, including gestational trophoblastic disease and pre-eclampsia. From stem cells through to epigenetics, implantation and X-chromosome inactivation, there is a lot to be learned about trophoblast, this volume provides a detailed summary of knowledge regarding the subject.

Author : Asim K. Duttaroy
Publisher : CRC Press
Page : 432 pages
File Size : 36,77 MB
Release : 2015-11-05
Category : Medical
ISBN : 1482254298

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Human Placental Trophoblasts: Impact of Maternal Nutrition explores the vital roles of trophoblasts play in fetal growth and pregnancy, giving you new insight into the modulation of placental trophoblast functions by nutrients. It also reviews the role of fatty acids, folic acids, and specific vitamins in this aspect. The book highlights the critic

Author : H.W. Denker
Publisher : Springer Science & Business Media
Page : 455 pages
File Size : 26,1 MB
Release : 2012-12-06
Category : Medical
ISBN : 1461306159

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Interest in mechanisms of embryo implantation is increasing, particularly with the realization that failure of implantation after in vitro fertilization and embryo transfer places significant limits on the success of treatment. In addition, there is a need to provide hypotheses, and ultimately mechanisms, for the high rates of embryonic loss in women in the population at large. Traditionally, implantation research has concentrated on genetics and endocrinology without providing many therapeutic benefits. A new era is now beginning with the application of modem cellular and molecular approaches to the investigation of the relationship between trophoblast and endometrium. At the same time, older data can be reevaluated in the light of current research into cell cell and cell-matrix interactions. The feeling that new avenues of research are open was apparent when an international group of scientists came together at a workshop on "The Cell Biology of Trophoblast Invasion In Vivo and In Vitro" held during the XXIV Annual Meeting of the Cell, Tissue and Organ Culture Study Group (C.T.O.C.) at Heidelberg in 1986. What was unusual about this Conference was the interdisciplinary dialogue between implantation researchers and tumor biologists, highlighting aspects common to invasion of trophoblast and tumor cells.

Author : C. Redman
Publisher : Wiley-Blackwell
Page : 608 pages
File Size : 40,60 MB
Release : 1993-01-18
Category : Medical
ISBN : 9780632027217

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The placenta is fascinating and complex. Basically foreign to the maternal body, it can be thought of as an organ transplanted onto the mother's host tissue. As such it embodies all the principles of tissue acceptance and rejection. Many of the risks of pregnancy and labor have now been eliminated and the placenta is likely to be at the root of many of the dangers to the unborn child that remain. A breakdown of the relationship between the placenta and the maternal tissue may turn out to be the cause of the majority of early lost pregnancies.

Author : Robert Pijnenborg
Publisher : Cambridge University Press
Page : 325 pages
File Size : 31,25 MB
Release : 2010-06-03
Category : Medical
ISBN : 1139488686

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It is now recognized that defective placentation in the human is a cause of many pregnancy complications, such as spontaneous abortion, preterm labor and delivery, pre-eclampsia, intrauterine growth restriction, fetal death and abruptio placenta. These clinical disorders can often have long-term consequences into adulthood, causing cardiovascular disease, obesity and diabetes for the newborn as well as an increased risk of premature death in the mother. This is the first book to be entirely focused on the placental bed, bringing together the results of basic and clinical research in cell biology, immunology, endocrinology, pathology, genetics and imaging to consolidate in a single, informative source for investigators and clinicians. Its core aim is to explore new approaches and improve current clinical practice. This is essential reading for clinicians in obstetric, cardiovascular and reproductive medicine.

Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
Page : 155 pages
File Size : 21,84 MB
Release : 2020-08-31
Category : Medical
ISBN : 0309676681

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Because of the recent advances in embryo modeling techniques, and at the request of the Office of Science Policy in the Office of the Director at the National Institutes of Health, the National Academies of Sciences, Engineering, hosted a 1-day public workshop that would explore the state of the science of mammalian embryo model systems. The workshop, which took place on January 17, 2020, featured a combination of presentations, panels, and general discussions, during which panelists and participants offered a broad range of perspectives. Participants considered whether embryo model systems - especially those that use nonhuman primate cells - can be used to predict the function of systems made with human cells. Presentations provided an overview of the current state of the science of in vitro development of human trophoblast. This publication summarizes the presentation and discussion of the workshop.

Author : Raymond W. Redline
Publisher : Cambridge University Press
Page : 367 pages
File Size : 12,55 MB
Release : 2018-08-23
Category : Medical
ISBN : 1316632539

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A guide to identifying disease processes in the placenta affecting pregnancy outcome, with current diagnostic criteria and clinical consequences.