[PDF] The Continual Condition eBook

Author : Charles Bukowski
Publisher : Harper Collins
Page : 146 pages
File Size : 43,49 MB
Release : 2010-10-05
Category : Poetry
ISBN : 006177121X

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In the literary pantheon, Charles Bukowski remains a counterculture luminary. A hard-drinking wild man of literature and a stubborn outsider to the poetry world, he has struck a chord with generations of readers, writing raw, tough poetry about booze, work, and women in an authentic voice that is, like the work of the Beats, iconoclastic and even dangerous. Edited by his longtime publisher, John Martin, of Black Sparrow Press, and now in paperback, The Continual Condition includes more of this legend’s never-before-collected poems.

Author : Janet R. Gilsdorf
Publisher : Oxford University Press
Page : 256 pages
File Size : 34,30 MB
Release : 2019-10-15
Category : Medical
ISBN : 0190677333

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Not all scientific discoveries are genius. Continual Raving tells the combined stories of how scientists across the 19th and 20th centuries defeated meningitis -- not through flawless scientific research, but often through a series of serendipitous events, misplaced assumptions, and flawed conclusions. The result is a story of not just a vanquished disease, but how scientific accomplishment sometimes occurs where it's least expected. Although symptoms of meningitis were recorded as early as Hippocrates and the ancient Greeks, our understanding of the disease's origins and mechanisms remained obscure for most of human history. That changed in 1892, when German physician Richard Pfeiffer observed and isolated bacteria ultimately shown to cause meningitis in children -- and concluded that those bacteria cause influenza. Haemophilus influenzae, as thee meningitis-causing bacteria have been erroneously named ever since, continued their strange journey to discovery in the decades that followed. Continual Raving traces the disease's strange encounters with science, including: · Heinrich Quincke, the German internist who first used a needle to draw spinal fluid from between a patient's back bones · Simon Flexner's management of American meningitis epidemics using immune serum from a horse · American bacteriologist Margaret Pittman's discovery (during the Great Depression, no less) of a sugar overcoat that protects the bacteria from white blood cells · Pediatrician Ashley Weech, who gave the first antibiotic used in America (based on instructions written in German) to a young patient sick with meningitis · Microbiologist Hattie Alexander, who learned why these antibiotics sometimes fail in such patients · Four scientists, in two teams, as they vied to be the first to create the right vaccine to prevent meningitis in infants In each of these deeply human stories, variables of chance, circumstance, and incorrect assumptions intervene to shape not just the arc of the scientists' lives, but the trajectory of how humans have come to understand one of our most pernicious diseases. Continual Raving is a mosaic tale of how science conquered meningitis -- and a larger story of the sometimes winding road to discovery.

Author : Nikky Finney
Publisher : Northwestern University Press
Page : 114 pages
File Size : 20,30 MB
Release : 2011-01-27
Category : Poetry
ISBN : 0810152169

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"In Nikky Finney's Head Off & Split the beauty of language soars and saves us even as we skirt the raw edge of terror. And something rare and precious is restored, a light, a circling movement of the spirit. This is poetry to give thanks for."---Meena Alexander, author of Quickly Changing River --

Author : Gary Soto
Publisher : Chronicle Books
Page : 196 pages
File Size : 40,23 MB
Release : 1995
Category : Poetry
ISBN : 9780811807586

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Soto writes with a pure sweetness free of sentimentality that is almost extraordinary in modern American poetry. -- Andrew Hudgins. Soto insists on the possibility of a redemptive power, and he celebrates the heroic, quixotic capacity for survival in human beings and the natural world. -- Publishers Weekly. Soto has it all -- the learned craft, the intrinsic abilities with language, a fascinating autobiography, and the storyteller's ability to manipulate memories into folklore. -- Library Journal.

Author : Jan Karon
Publisher : Penguin
Page : 192 pages
File Size : 45,34 MB
Release : 2006-02-28
Category : Fiction
ISBN : 1101200995

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From Jan Karon, the #1 New York Times bestselling author of the Mitford series comes a collection of Father Tim's favorite words of wisdom and spiritual inspiration... For years, Mitford’s Father Tim Kavanagh has transcribed into his dog-eared journals words of wisdom, faith, and encouragement. Written in his own hand or typed on his idiosyncratic Royal typewriter, A Continual Feast contains the lively ideas, common sense, profound wisdom, and plain good humor he has gleaned from the likes of C. S. Lewis, Emily Dickinson, William Blake, Helen Keller, G. K. Chesterton, and Will Rogers, to name just a few. Together with its successful companion volume, Patches of Godlight, Father Tim’s latest quote journal is sure proof of the truth of an entry from Lord Byron: "A small drop of ink produces that which makes thousands think." This entertaining and useful handbook is for all those who relish a good “Aha!,” including authors, clergy, speechmakers, dog lovers, and anyone who enjoys provocative insight into everything from the righteous to the ridiculous.

Author : Charles Bukowski
Publisher : Harper Collins
Page : 288 pages
File Size : 23,1 MB
Release : 2009-10-06
Category : Fiction
ISBN : 0061979988

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in this place there are the dead, the deadly and the dying. there is the cross, the builders of the cross and the burners of the cross. the pattern of my life forms like a cheap shadow on the wall before me. my love what is left of it now must crawl to wherever it can crawl. the strongest know that death is final and the happiest are those gifted with the shortest journey.

Author : Ying Kuen Cheung
Publisher : CRC Press
Page : 207 pages
File Size : 16,38 MB
Release : 2011-03-29
Category : Mathematics
ISBN : 1420091514

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As clinicians begin to realize the important role of dose-finding in the drug development process, there is an increasing openness to "novel" methods proposed in the past two decades. In particular, the Continual Reassessment Method (CRM) and its variations have drawn much attention in the medical community, though it has yet to become a commonplace tool. To overcome the status quo in phase I clinical trials, statisticians must be able to design trials using the CRM in a timely and reproducible manner. A self-contained theoretical framework of the CRM for researchers and graduate students who set out to learn and do research in the CRM and dose-finding methods in general, Dose Finding by the Continual Reassessment Method features: Real clinical trial examples that illustrate the methods and techniques throughout the book Detailed calibration techniques that enable biostatisticians to design a CRM in timely manner Limitations of the CRM are outlined to aid in correct use of method This book supplies practical, efficient dose-finding methods based on cutting edge statistical research. More than just a cookbook, it provides full, unified coverage of the CRM in addition to step-by-step guidelines to automation and parameterization of the methods used on a regular basis. A detailed exposition of the calibration of the CRM for applied statisticians working with dose-finding in phase I trials, the book focuses on the R package ‘dfcrm’ for the CRM and its major variants. The author recognizes clinicians’ skepticism of model-based designs, and addresses their concerns that the time, professional, and computational resources necessary for accurate model-based designs can be major bottlenecks to the widespread use of appropriate dose-finding methods in phase I practice. The theoretically- and empirically-based methods in Dose Finding by the Continual Reassessment Method will lessen the statistician’s burden and encourage the continuing development and implementation of model-based dose-finding methods.

Author : Charles Bukowski
Publisher : Harper Collins
Page : 372 pages
File Size : 31,10 MB
Release : 2009-03-17
Category : Poetry
ISBN : 0061871435

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This is a collection of 175 previously unpublished works by Bukowski. It contains yarns about his childhood in the Depression and his early literary passions, his apprentice days as a hard-drinking, starving poetic aspirant, and his later years when he looks back at fate with defiance.

Author : Kevin Young
Publisher : Knopf
Page : 209 pages
File Size : 44,68 MB
Release : 2015-10-13
Category : Poetry
ISBN : 0375711880

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A decade after the sudden and tragic loss of his father, we witness the unfolding of grief. “In the night I brush / my teeth with a razor,” he tells us, in one of the collection’s piercing two-line poems. Capturing the strange silence of bereavement (“Not the storm / but the calm / that slays me”), Kevin Young acknowledges, even celebrates, life’s passages, his loss transformed and tempered in a sequence about the birth of his son: in “Crowning,” he delivers what is surely one of the most powerful birth poems written by a man, describing “her face / full of fire, then groaning your face / out like a flower, blood-bloom,/ crocused into air.” Ending this book of both birth and grief, the gorgeous title sequence brings acceptance, asking “What good/are wishes if they aren’t / used up?” while understanding “How to listen / to what’s gone.” Young’s frank music speaks directly to the reader in these elemental poems, reminding us that the right words can both comfort us and enlarge our understanding of life’s mysteries.