[PDF] The Cell Cycle In The Central Nervous System eBook

Author : Damir Janigro
Publisher : Springer Science & Business Media
Page : 555 pages
File Size : 41,32 MB
Release : 2008-01-23
Category : Medical
ISBN : 1597450219

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Cell Cycle in the Central Nervous System overviews the changes in cell cycle as they relate to prenatal and post natal brain development, progression to neurological disease or tumor formation.Topics covered range from the cell cycle during the prenatal development of the mammalian central nervous system to future directions in postnatal neurogenesis through gene transfer, electrical stimulation, and stem cell introduction. Additional chapters examine the postnatal development of neurons and glia, the regulation of cell cycle in glia, and how that regulation may fail in pretumor conditions or following a nonneoplastic CNS response to injury. Highlights include treatments of the effects of deep brain stimulation on brain development and repair; the connection between the electrophysiological properties of neuroglia, cell cycle, and tumor progression; and the varied immunological responses and their regulation by cell cycle.

Author : R.S. Nowakowski
Publisher : Karger Medical and Scientific Publishers
Page : 212 pages
File Size : 28,34 MB
Release : 2004
Category : Medical
ISBN : 3805578709

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This publication focuses on the biology of stem and progenitor cells in the developing and mature central nervous system, their response to trauma and potential uses in therapy. The authors, who are leading experts in the field, address topical questions from both basic and clinical neuroscience perspectives such as: non-invasive imaging of stem cell division; the origins of regional diversity in cell types and cell numbers in the stem cell progeny; factors that regulate generation of neurons and glial cells from stem cells during normal development; the role of genetic and environmental factors in the regulation of stem cell function; the role of stem cells in mediating the effects of brain trauma and its recovery, and the therapeutic uses of stem cells. Offering a unique compilation of articles on the biology and the therapeutic applications of stem cells in the embryonic and mature nervous systems, this volume will be of great value to neuroscientists, developmental biologists, cancer biologists and clinical neurologists.

Author : Dorota Lubanska
Publisher : LAP Lambert Academic Publishing
Page : 88 pages
File Size : 30,56 MB
Release : 2014-06-05
Category :
ISBN : 9783659547782

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Development of the central nervous system remains under strict control of the cell cycle. Spatial and temporal onset and completion of both neuro- and gliogenesis are regulated by several cell cycle proteins. Importantly, proteins comprising G1 phase regulatory network are involved in the control of stemness and/or lineage commitment balance in the pools of neural stem cells throughout the development. Deviation from this balance may lead to aberrant changes in cell division resulting in formation of brain tumour initiating cells (BTICs) which are at the source of human glioblastoma. This book provides a brief review of the cell cycle regulation at the embryonic and postnatal stages of neural development. Based on recent literature, a discussion on the role of G1 phase cyclins, cell cycle inhibitors and a novel cell cycle regulator, Spy1, in neural cell fate decisions, including mode of division and brain tumour formation, is provided in detail. The content of this book will aid in understanding how normal neural cells rely on cell cycle to control their growth and differentiation throughout life and how aberrant changes to certain cell cycle proteins contribute to gliomagenesis

Author : Antonio Giordano
Publisher : Springer Science & Business Media
Page : 259 pages
File Size : 32,43 MB
Release : 2010-08-17
Category : Medical
ISBN : 1603271538

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Complex physiopathological relationships have been proven to exist between two of the body’s most vital organs; the brain and the heart. In Cell Cycle Regulation and Differentiation in Cardiovascular and Neural Systems Antonio Giordano, Umberto Galderisi and a panel of the most respected authorities in their field offer an in-depth analysis of the differentiation process in two systems that have profound relationships with one another. The text looks at several aspects of the cardiovascular and nervous systems from a new point of view, describing the differences and similarities in their differentiation pathways with an emphasis on the role of cell cycle regulation and cell differentiation. Topics discussed include neurogenesis in the central nervous system, neural stem cells, and the basic-helix-loop-helix transcription factors in neural differentiation. Ground-breaking and authoritative, Cell Cycle Regulation and Differentiation in Cardiovascular and Neural Systems is a must have for all researchers in cardiovascular medicine and neuroscience and will prompt the scientific community to perceive cell cycle regulation and differentiation under a novel and more comprehensive light.

Author : Kerry L. Tucker
Publisher : Springer Science & Business Media
Page : 286 pages
File Size : 41,8 MB
Release : 2013-01-19
Category : Medical
ISBN : 9400758081

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Cilia are tiny microtubule-based organelles projecting from the plasma membrane of practically all cells in the body. In the past 10 years a flurry of research has indicated a crucial role of this long-neglected organelle in the development and function of the central nervous system. A common theme of these studies is the critical dependency of signal transduction of the Sonic hedgehog, and more recently, Wnt signaling pathways upon cilia to regulate fate decisions and morphogenesis. Both primary and motile cilia also play crucial roles in the function of the nervous system, including the primary processing of sensory information, the control of body mass, and higher functions such as behavior and cognition, serving as "antennae" for neurons to sense and process their environment. In this book we describe the structure and function of cilia and the various tissues throughout the brain and spinal cord that are dependent upon cilia for their proper development and function.

Author : National Academy of Sciences
Publisher : National Academies Press
Page : 195 pages
File Size : 24,52 MB
Release : 1992-01-01
Category : Medical
ISBN : 0309045290

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The brain ... There is no other part of the human anatomy that is so intriguing. How does it develop and function and why does it sometimes, tragically, degenerate? The answers are complex. In Discovering the Brain, science writer Sandra Ackerman cuts through the complexity to bring this vital topic to the public. The 1990s were declared the "Decade of the Brain" by former President Bush, and the neuroscience community responded with a host of new investigations and conferences. Discovering the Brain is based on the Institute of Medicine conference, Decade of the Brain: Frontiers in Neuroscience and Brain Research. Discovering the Brain is a "field guide" to the brainâ€"an easy-to-read discussion of the brain's physical structure and where functions such as language and music appreciation lie. Ackerman examines: How electrical and chemical signals are conveyed in the brain. The mechanisms by which we see, hear, think, and pay attentionâ€"and how a "gut feeling" actually originates in the brain. Learning and memory retention, including parallels to computer memory and what they might tell us about our own mental capacity. Development of the brain throughout the life span, with a look at the aging brain. Ackerman provides an enlightening chapter on the connection between the brain's physical condition and various mental disorders and notes what progress can realistically be made toward the prevention and treatment of stroke and other ailments. Finally, she explores the potential for major advances during the "Decade of the Brain," with a look at medical imaging techniquesâ€"what various technologies can and cannot tell usâ€"and how the public and private sectors can contribute to continued advances in neuroscience. This highly readable volume will provide the public and policymakersâ€"and many scientists as wellâ€"with a helpful guide to understanding the many discoveries that are sure to be announced throughout the "Decade of the Brain."

Author : Dan H. Sanes
Publisher : Academic Press
Page : 513 pages
File Size : 33,64 MB
Release : 2000-06-07
Category : Medical
ISBN : 0080951473

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Development of the Nervous System presents a broad outline of neural development principles as exemplified by key experiments and observations from past and recent times. The text is organized along a development pathway from the induction of the neural primordium to the emergence of behavior. It covers all the major topics including the patterning and growth of the nervous system, neuronal determination, axonal navigation and targeting, synapse formation and plasticity, and neuronal survival and death. This new text reflects the complete modernization of the field achieved through the use of model organisms and the intensive application of molecular and genetic approaches. Original, artist-rendered drawings combined with clear, concise writing make Development of the Nervous System well suited to anyone approaching this complex field for the first time. Key Features * Provides a synopsis of concepts and experimental strategies * Includes designs of critical experiments that are easy to understand * Outlines the molecular and genetic bases for many developmental events * Presents new information on the function of the developing central nervous system * Richly illustrated with original drawings * Treats the field as an experimental rather than a descriptive science * Written at a level that is appropriate for undergraduates and beyond

Author : Samantha Fowler
Publisher :
Page : 618 pages
File Size : 25,83 MB
Release : 2018-01-07
Category : Science
ISBN : 9789888407453

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Concepts of Biology is designed for the single-semester introduction to biology course for non-science majors, which for many students is their only college-level science course. As such, this course represents an important opportunity for students to develop the necessary knowledge, tools, and skills to make informed decisions as they continue with their lives. Rather than being mired down with facts and vocabulary, the typical non-science major student needs information presented in a way that is easy to read and understand. Even more importantly, the content should be meaningful. Students do much better when they understand why biology is relevant to their everyday lives. For these reasons, Concepts of Biology is grounded on an evolutionary basis and includes exciting features that highlight careers in the biological sciences and everyday applications of the concepts at hand.We also strive to show the interconnectedness of topics within this extremely broad discipline. In order to meet the needs of today's instructors and students, we maintain the overall organization and coverage found in most syllabi for this course. A strength of Concepts of Biology is that instructors can customize the book, adapting it to the approach that works best in their classroom. Concepts of Biology also includes an innovative art program that incorporates critical thinking and clicker questions to help students understand--and apply--key concepts.