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Author : Brian Andrew Hills
Publisher : Cambridge University Press
Page : 432 pages
File Size : 13,54 MB
Release : 1988
Category : Phospholipids
ISBN : 9780521307284
Author : Brian A. Hills
Publisher :
Page : 520 pages
File Size : 14,44 MB
Release : 1988
Category : Medical
ISBN :
This book attempts to explain the mechanisms by which surfactants - specifically, the surface-active phospholipids - exert their physiological functions in the body. There is much controversy as to the role of surfactant in the lung, and the veracity of the various alveolar models, which are clearly evaluated in The Biology of Surfactant. The text goes on to describe the nature of surfactant in the gastro-intestinal tract, joints and at tissue surfaces in other organs where it could have several useful functions. These are related to work on synthetic- surfactants which may shed light on natural mechanisms with important implications for medical research. In each of these the underlying physico-chemical principles are emphasized in a manner accessible to the biologist and physician. By giving an overview of theories as to the role and mechanism of surfactants - including hid own forthright views - Professor Hills has provided a comprehensive and stimulating text. The volume will appeal to researchers and students of physiology, paediatrics, obstetrics, rheurnatology, neonatology; specialists in pulmonary physiology and chest diseases; surgeons, biochemists, microbiologists whose work relates to surfactants in the lung and other organs.
Author : D. Attwood
Publisher : Springer Science & Business Media
Page : 802 pages
File Size : 33,27 MB
Release : 2012-12-06
Category : Science
ISBN : 9400957750
It is now twelve years since Solubilization by Surface-Active Agents appeared. Since the publication of that monograph the subject has expanded rapidly as the unique potential of surfactants has become known to a wider circle of scientists. In a recent review Menger (Accounts of Chemical Research, 12 (1979) 111) estimated that since 1970 there have been over 2800 publications on micelles and micellization alone. The topic of catalysis in micellar media was in an early stage of development in 1968 but the growth in this subject has given rise to an excellent textbook by Fendler and Fendler. We have felt for some time that a revision of Solubilization by Surface-Active Agents was overdue. The book has been out of print for some time. Owing to pressure of other work, Professor P. H. Elworthy and Dr C. B. Macfarlane were unable to undertake the work of revision but while working together on an undergraduate textbook the present authors decided to set to work, realizing both the impossibility of producing a comprehensive textbook and the need to alter the scope of the book. Micellar solubilization occurs over a relatively small surfactant concentration range; because of this and because the phenomenon is never observed in isolation, we have extended the text to include surface activity, emulsions and suspensions and, as our emphasis is on formulation of medicinal products, to the of the toxicology of surface-active agents.
Author : Bengt Robertson
Publisher : Elsevier Publishing Company
Page : 800 pages
File Size : 17,82 MB
Release : 1992
Category : Medical
ISBN :
There has been a spectacular development in both basic research on the pulmonary surfactant system and the clinical use of surfactant for treatment of lung diseases, especially in the neonatal period. In particular, the molecular biology and physiological roles of the surfactant-associated proteins (SP-A) have been clarified during the last few years; the structure and functions of these proteins therefore constitute an important hot topic, and are reviewed in several chapters of this volume. including surface chemistry and ultrastructure of surfactant components, the role of surfactant in lung mechanics and alveolar liquid homeostasis, and surfactant metabolism and its hormonal control. However, as mentioned above, clinical applications of surfactant research have become increasingly important and are therefore dealt with extensively in the remaining chapters. during the last few years to illustrate the fascinating complexity of the surfactant system. Hence, the main mission of this volume is to catalyze the future development in this field with the exchange of ideas between scientific workers from different disciplines.
Author : Robert W. Wilmott
Publisher : Elsevier Health Sciences
Page : 1163 pages
File Size : 15,62 MB
Release : 2012-02-25
Category : Medical
ISBN : 1455740500
Kendig, Chernick’s Disorders of the Respiratory Tract in Children is the definitive medical reference book to help you confront critical challenges using the latest knowledge and techniques. You’ll get the state-of-the-art answers you need to offer the best care to young patients. Tackle the toughest challenges and improve patient outcomes with coverage of all the common and rare respiratory problems found in newborns and children worldwide. Get a solid foundation of knowledge to better understand and treat your patients through coverage of the latest basic science and its relevance to clinical problems. Get comprehensive, authoritative coverage on today’s hot topics, such as interstitial lung disease, respiratory disorders in the newborn, congenital lung disease, swine flu, genetic testing for disease and the human genome, inflammatory cytokines in the lung, new radiologic techniques, diagnostic imaging of the respiratory tract, and pulmonary function tests. Learn from the experts with contributions from 100 world authorities in the fields of pediatrics, pulmonology, neurology, microbiology, cardiology, physiology, diagnostic imaging, anesthesiology, otolaryngology, allergy, and surgery.
Author : Robert H. Notter
Publisher : CRC Press
Page : 476 pages
File Size : 47,18 MB
Release : 2000-07-18
Category : Science
ISBN : 9780824704018
Integrating basic and clinical research on the biophysical and physiological functions of pulmonary surfactants, this practical reference presents thorough, cutting-edge coverage on surfactant-related lung disease. Manage neonatal respiratory distress syndrome (RDS), acute respiratory distress syndrome (ARDS), and acute lung injury more effectively!
Author : D. Attwood
Publisher : Springer
Page : 794 pages
File Size : 11,89 MB
Release : 2011-11-18
Category : Science
ISBN : 9789400957770
It is now twelve years since Solubilization by Surface-Active Agents appeared. Since the publication of that monograph the subject has expanded rapidly as the unique potential of surfactants has become known to a wider circle of scientists. In a recent review Menger (Accounts of Chemical Research, 12 (1979) 111) estimated that since 1970 there have been over 2800 publications on micelles and micellization alone. The topic of catalysis in micellar media was in an early stage of development in 1968 but the growth in this subject has given rise to an excellent textbook by Fendler and Fendler. We have felt for some time that a revision of Solubilization by Surface-Active Agents was overdue. The book has been out of print for some time. Owing to pressure of other work, Professor P. H. Elworthy and Dr C. B. Macfarlane were unable to undertake the work of revision but while working together on an undergraduate textbook the present authors decided to set to work, realizing both the impossibility of producing a comprehensive textbook and the need to alter the scope of the book. Micellar solubilization occurs over a relatively small surfactant concentration range; because of this and because the phenomenon is never observed in isolation, we have extended the text to include surface activity, emulsions and suspensions and, as our emphasis is on formulation of medicinal products, to the of the toxicology of surface-active agents.
Author : Venkataramana K Sidhaye
Publisher : Academic Press
Page : 277 pages
File Size : 28,73 MB
Release : 2017-03-09
Category : Medical
ISBN : 0128038810
Lung Epithelial Biology in the Pathogenesis of Pulmonary Disease provides a one-stop resource capturing developments in lung epithelial biology related to basic physiology, pathophysiology, and links to human disease. The book provides access to knowledge of molecular and cellular aspects of lung homeostasis and repair, including the molecular basis of lung epithelial intercellular communication and lung epithelial channels and transporters. Also included is coverage of lung epithelial biology as it relates to fluid balance, basic ion/fluid molecular processes, and human disease. Useful to physician and clinical scientists, the contents of this book compile the important and most current findings about the role of epithelial cells in lung disease. Medical and graduate students, postdoctoral and clinical fellows, as well as clinicians interested in the mechanistic basis for lung disease will benefit from the books examination of principles of lung epithelium functions in physiological condition. Provides a single source of information on lung epithelial junctions and transporters Discusses of the role of the epithelium in lung homeostasis and disease Includes capsule summaries of main conclusions as well as highlights of future directions in the field Covers the mechanistic basis for lung disease for a range of audiences
Author : Kaushik Nag
Publisher : CRC Press
Page : 528 pages
File Size : 36,68 MB
Release : 2019-08-30
Category :
ISBN : 9780367392895
The only source to describe the lung surfactant as a complex membranous system, this guide analyzes lung surfactant function from the aspects of molecular biology, biophysics, membrane science, and surface and interface analysis and reviews the latest basic and clinical issues relating to lung disease and (dys)function.
Author : Alan H. Jobe
Publisher : Cambridge University Press
Page : pages
File Size : 28,95 MB
Release : 2016-04-18
Category : Medical
ISBN : 1316665178
Lung disease affects more than 600 million people worldwide. While some of these lung diseases have an obvious developmental component, there is growing appreciation that processes and pathways critical for normal lung development are also important for postnatal tissue homeostasis and are dysregulated in lung disease. This book provides an authoritative review of fetal and neonatal lung development and is designed to provide a diverse group of scientists, spanning the basic to clinical research spectrum, with the latest developments on the cellular and molecular mechanisms of normal lung development and injury-repair processes, and how they are dysregulated in disease. The book covers genetics, omics, and systems biology as well as new imaging techniques that are transforming studies of lung development. The reader will learn where the field of lung development has been, where it is presently, and where it is going in order to improve outcomes for patients with common and rare lung diseases.