[PDF] Synthesis Of Novel Fluorinated Organic Compounds By Direct Fluorination eBook

Author : Richard J. Lagow
Publisher :
Page : 57 pages
File Size : 31,9 MB
Release : 1977
Category :
ISBN :

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It has been found possible to preserve metal-carbon and metalloid-carbon bonds during direct fluorination. The reaction of dimethylmercury with fluorine gives bis(trifluoromethyl)mercury in 6.5% yield. Fluorination of tetramethylsilane has led to the isolation of the new polyfluorotetramethylsilanes of the following type, Si(CH3)x(CH2F)y(CHF2)z, x+y+z = 4. Also characterized were compounds containing Si-CF3. It has been possible to synthesize tetrakis(trifluoromethyl)germanium in 63,5% yield from the reaction of fluorine with tetramethylgermanium. Also characterized were many polyfluorotetramethylgermanes of the following type, Ge(CF3)x(CF2H)y(CFH2)z, z + y + z = 4. (Author).

Author : James H. Clark
Publisher : CRC Press
Page : 362 pages
File Size : 17,37 MB
Release : 2018-01-10
Category : Science
ISBN : 1351086782

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Academia and industry join forces in Aromatic Fluorination, as an expert from each domain contributes to this new text on fluorination of carbocyclic and heterocyclic rings. The book begins with a discussion of fluorine's unique combination of properties, including size, electronic effects, and hydrophobicity, as well as the historical development of its product applications. It explains methods for introducing fluorine into an aromatic ring, focusing on nucleophilic fluorine transfer reactions. The role of catalysts, solvents, and other variables are examined, and the scope and limitations of the methods are discussed. Of particular interest to those working in non-specialist laboratories, Aromatic Fluorination includes detailed descriptions of the new electrophilic routes to fluoroaromatics, in addition to traditional routes and alternative methods involving radical chemistry. Because one of the most important fluorine-containing substituent is CF3, the book explains routes to benzotrifluorides (ArCF3), including traditional industrial methods and modern alternatives employing C-1 halofluorocarbons and other fluoroaliphatics. An alternative to CF3 is CF3S, and several methods of synthesizing aromatic CF3S-containing molecules are described. Since the successful development and diverse applications of aromatic fluorine compounds have led to the search for new compounds and novel substituents, the incorporation of other substituents is also explored. Aromatic Fluorination concludes with discussion of the factors responsible for the successful development of pharmaceutical, agrochemical and liquid crystal applications and the potential for applications in high-performance polymers and other areas. This section also describes in detail important industrial aromatic fluorination processes and the relative merits of different process technologies and their costs.

Author : Richard J. Lagow
Publisher :
Page : 15 pages
File Size : 50,31 MB
Release : 1978
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ISBN :

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Final report of research done utilizing a fluorination technique for the synthesis of perfluorinated and polyfluorinated organic compounds. (Author).

Author : John L. Margrave
Publisher :
Page : 38 pages
File Size : 34,92 MB
Release : 1972
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ISBN :

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The synthesis of perfluoro organic compounds by direct fluorination has been studied. The compounds studied included: ortho-toluic acid, meta-toluic acid, para-toluic acid, sodium acetate, diglycolic acid, diphenyl ether, 2- ethoxyethylacetate, 3-oxoglutaric acid, 2-oxoglutaric acid, methoxyasetic acid, methoxyphenoxyacetic acid, diethyl carbonate, malonic acid, adipic acid. These materials have been fluorinated at low concentrations of fluorine and at a variety of temperatures varying from room temperature to -78C. Invariably with extremely low fluorine con-centrations, the resulting products contained very little fluorinated material as evidenced by their infrared spectra. Under longer reaction times and/or higher fluorine concentrations, the materials tended to be degraded into low molecular weight volatiles. Polyethylene has been surface fluorinated and the kinetics of the process have been studied from 25 to 50 C. The rate of constants for each temperature and the activation energy of the process are reported. Natural rubber samples were surface treated with fluorine and appear to survive acceptably with a subsequent lowering of surface energy. Matrix isolation studies of organic molecules in fluorine matrices are also reported. The species studied were methane, ethane, ethylene, acetylene, and formic acid. It was found that fluorine molecules at 4-15 K behaved essentially like an inert substrate, but fluorine atoms, prepared in situ by photolysis, are very reactive and lead to various fluorinated derivatives.

Author : I.L. Knunyants
Publisher : Springer Science & Business Media
Page : 307 pages
File Size : 18,72 MB
Release : 2012-12-06
Category : Science
ISBN : 3642702074

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Recently there has been a tremendous growth in the chemistry of fluoroorganic compounds, which find wide applicatiori in various fields of technique and are used to solve some basic theoretical problems. The chemical properties of these compounds are rather specific, as well as the methods for their preparation. We realized that no good handbooks on the preparation offluoro organic compounds were available, whereas the methods of pre paration are scattered in numerous scientific papers and patents. Even such a well-known publication as Organic Syntheses contains just a few methods of preparation of fluoroorganic compounds. As a consequence, not only for newcomers but even for specialists, searching for simple and convenient methods for the preparation of the required compounds is tedious. To alleviate the problem, we undertook to prepare this book, which presents detailed preparation methods of more than 300 flu oro organic compounds. Emphasis has been laid on syntheses of polyfluorinated compounds, since they are of major interest with respect to preparation and utility. Preparation of fluoroorganic compounds is based both on the classical methods of organic chemistry and on the specific ones, which is due to the difficulty or even impossibility of the direct introduction of fluorine into a definite position of organic mole cule. Most organic compounds of fluorine are prepared by a suc cession of conversions of a relatively small number of starting compounds.

Author : Henri Groult
Publisher : Elsevier
Page : 792 pages
File Size : 39,28 MB
Release : 2016-11-04
Category : Science
ISBN : 0128037903

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Modern Synthesis Processes and Reactivity of Fluorinated Compounds focuses on the exceptional character of fluorine and fluorinated compounds. This comprehensive work explores examples taken from all classes of fluorine chemistry and illustrates the extreme reactivity of fluorinating media and the peculiar synthesis routes to fluorinated materials. The book provides advanced and updated information on the latest synthesis routes to fluorocompounds and the involved reaction mechanisms. Special attention is given to the unique reactivity of fluorine and fluorinated media, along with the correlation of those properties to valuable applications of fluorinated compounds. Contains quality content edited, and contributed, by leading scholars in the field Presents applied guidance on the preparation of original fluorinated compounds, potentially transferable from the lab scale to industrial applications Provides practical synthesis information for a wide audience interested in fluorine compounds in many branches of chemistry, materials science, and physics

Author : L.A. Alekseeva
Publisher : Springer
Page : 306 pages
File Size : 25,76 MB
Release : 1989-11-02
Category : Science
ISBN :

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The book summarizes and gives a critical analysis of the literature on the use of reactive covalent fluorides (organic and inorganic) for the synthesis of fluoroorganic compounds. New methods of using SF4 for the fluorination of complex polyfunctional organic compounds are described. The prospects are shown for the selective fluorinations of complex compounds with non-traditional fluorinating agents (halogen fluorides, XeF2, fluorosulphuranes, N-F- and O-F-containing compounds). The book gives recommendations for the practical use of these fluorides, and typical synthetic procedures. It introduces the beginner to modern methods of fluorination and helps qualified scientists and technologists to choose the optimal methods of synthesis. Using the fluorinating agents described in this book, it is possible to synthesize various fluorine-containing substances.