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Supplementary Mutagenicity Tests

United Kingdom Environmental Mutagen Society. Sub-Committee on Guidelines for Mutagenicity Testing
Supplementary Mutagenicity Tests by United Kingdom Environmental Mutagen Society. Sub-Committee on Guidelines for Mutagenicity Testing PDF

Author : United Kingdom Environmental Mutagen Society. Sub-Committee on Guidelines for Mutagenicity Testing
Publisher : Cambridge University Press
Page : 179 pages
File Size : 49,78 MB
Release : 1993-11-11
Category : Medical
ISBN : 052145073X

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Originally published in 1993, this volume describes supplementary tests used to assess risks of in vitro mutagenicity when basic safety tests were inconclusive.

Supplementary Mutagenicity Tests

David J. Kirkland
Supplementary Mutagenicity Tests by David J. Kirkland PDF

Author : David J. Kirkland
Publisher : Cambridge University Press
Page : 176 pages
File Size : 13,63 MB
Release : 1993-11-11
Category : Medical
ISBN : 9780521450737

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Originally published in 1993, this volume describes a complementary selection of tests to those described in the companion volume Basic Mutagenicity Tests (Cambridge University Press, 1990). These supplementary tests were used to assess risks of in vitro mutagenicity in those instances where the basic tests were inconclusive. As such, these tests had an important role in the assessment of the safety of compounds, drugs and chemicals. These supplementary test and guidelines, originally drawn up by the United Kingdom Environmental Mutagen Society (UKEMS) were fully revised in this publication to take full account of different regulatory guidelines and scientific advances. This volume will be of value to anyone with aninterest in regulatory affairs, mutagenicity testing and the registration of chemical products in the UK and Europe.

Handbook of Mutagenicity Test Procedures

B.J. Kilbey
Handbook of Mutagenicity Test Procedures by B.J. Kilbey PDF

Author : B.J. Kilbey
Publisher : Elsevier
Page : 876 pages
File Size : 27,74 MB
Release : 2012-12-02
Category : Medical
ISBN : 0444600981

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The compilation of this book was prompted by the necessity of a bench volume which could provide the necessary background information on materials, experimental design, pitfalls and dificulties, in order to perform a particular test in an acceptable way with a minimal need for additional expert help. This Second Edition updates this information, providing: - a comprehensive bench guide - methods known to be reliable - a broad spectrum of approaches - tips to avoid pitfalls when using unfamiliar techniques - data from population records - safety aspects of mutagens and carcinogens - basic statistical concepts for experiment design This `on the bench' methodological text provides the necessary information for most of the common assays for genetic damage in use. The book includes methods which have been sufficiently used and tested to make their use reliable, but also presents methods which are not widely used at present, but which might prove most useful in screening for mutagenic effects.