[PDF] Substance P eBook

Author : Peter Holzer
Publisher : Springer Science & Business Media
Page : 596 pages
File Size : 15,3 MB
Release : 2004-06-17
Category : Medical
ISBN : 9783540206903

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The tachykinins represent one of the most thoroughly investigated family of neuropeptides, whose members and receptors have been characterized at the genetic and molecular level and whose pharmacology has now been advanced to the first clinical application. These exciting accomplishments and prospects are reviewed and discussed in this volume in an authoritative manner. Particular emphasis is laid on the development of selective non-peptide antagonists for all 3 tachykinin receptors and their potential as novel drugs in a variety of diseases. The approval of the first tachykinin receptor antagonist as an antiemetic drug is particularly highlighted, and the utility of tachykinin receptor antagonists in affective disorders, chronic obstructive airway disease and irritable bowel syndrome, to name a few indications, is extensively considered.

Author : Ruth Porter
Publisher : John Wiley & Sons
Page : 192 pages
File Size : 15,93 MB
Release : 2009-09-14
Category : Medical
ISBN : 0470718420

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The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.

Author : George Paxinos
Publisher : Academic Press
Page : 1211 pages
File Size : 26,44 MB
Release : 2012-12-02
Category : Science
ISBN : 0323139892

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The Human Nervous System is a definitive account of human neuroanatomy, with a comprehensive coverage of the brain, spinal cord, and peripheral nervous system. The cytoarchitecture, chemoarchitecture, connectivity, and major functions of neuronal structures are examined by acknowledged authorities in the field, such as: Alheid, Amaral, Armstrong, Beitz, Burke, de Olmos, Difiglia, Garey, Gerrits, Gibbins, Holstege, Kaas, Martin, McKinley, Norgren, Ohye, Paxinos, Pearson, Pioro, Price, Saper, Sasaki, Schoenen, Tadork, Voogd, Webster, Zilles, and their associates. Large, clearly designed 8-1/2" x 11" format 35 information-packed chapters 500 photomicrographs and diagrams 6,200 bibliographic entries Table of contents for every chapter Exceptionally cross-referenced Detailed subject index Substantial original research work Mini atlases of some brain regions

Author : Cris S. Constantinescu
Publisher : Springer
Page : 345 pages
File Size : 49,96 MB
Release : 2016-05-24
Category : Medical
ISBN : 3319286099

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This book addresses important issues regarding the interaction between the nervous system, the immune system, and the digestive system. Gut flora has a profound influence on the shaping of the immune response, not only in the gastrointestinal system but also in the nervous system. Fascinatingly, manipulation of intestinal immune responses can be used to modulate neurological disease. Conversely, the nervous system and the psyche have significant effects on the functioning of the gut and liver. After introductory chapters on the neurology, the immunology and microbiology of the gut, the effects of the gut immune system and gut flora and its manipulation on neurological disease are discussed, followed by molecular mimicry and immune tolerance in neuroimmune diseases. Additionally, several chapters deal with gastrointestinal manifestations of neurological diseases. Neuro-Immuno-Gastroenterology is aimed at neurologists, gastroenterologists, and immunologists.

Author : Fleur L. Strand
Publisher : MIT Press
Page : 678 pages
File Size : 27,35 MB
Release : 1999
Category : Neuropeptides
ISBN : 9780262194075

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This textbook is the first to bring together and synthesize the neuropeptide research of the past decade in such a comprehensive, scholarly manner. In recent years there has been increasing interest and, subsequently, active research in neuropeptides. These neuroactive molecules coordinate, integrate, and regulate physiological processes in all organisms, throughout all phases of development. Acting as neurohormones, neurotransmitters, and/or neuromodulators, they maintain physiological homeostasis and influence important behavioral patterns. This textbook is the first to bring together and synthesize the neuropeptide research of the past decade in such a comprehensive, scholarly manner. The book is divided into two parts. In Part I the author defines the basic principles of neuropeptide action, including their biosynthesis, processing, transport, distribution, and interactions with receptors and second messenger systems. Strand also discusses the intimate interaction between the neuropeptides, stress, and the immune system. In Part II she discusses the regulatory functions of the families of neuropeptide in sufficient detail to provide both the advanced student and senior investigator with a thorough understanding of the most important neuropeptides. The text also contains a complete and up-to-date reference/reading list.

Author : Robert Vink
Publisher : Elsevier
Page : 0 pages
File Size : 46,93 MB
Release : 2024-11-21
Category : Science
ISBN : 0443221952

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Substance P in Health and Disease provides a complete discussion of substance P biology, its role in normal physiology and a variety of diseases.It provides an introduction to substance P and its pharmacology, followed by exploring its role across the human body including gastrointestinal function, cardiovascular function, learning and memory, emesis, respiration and sleep. It then discusses the critical role of substance P in several disease states including brain injury, neurodegeneration, seizures, depression and anxiety, cancer, musculoskeletal disorders, and viral infection, including COVID-19. The book closes with a look towards future perspectives for substance P.Substance P in Health and Disease is the latest volume in the Molecular Mediators in Health and Disease series and is an ideal reference for researchers across the life sciences interested in understanding the role of this multi-functioning mediator and its biological significance. • Provides a comprehensive overview of the role of substance P across different organ systems, including the gut, the cardiovascular system and renal function• Includes detailed coverage of the specific actions of substance P in various disease states and conditions, such as inflammation, cancer, neurotrauma, Parkinson’s disease, Alzheimer’s disease and viral infection including COVID-19• Examines substance P as a modulator of pain perception• Includes expertise from a range of interdisciplinary areas including molecular biology, pharmacology, physiology, neuroscience, anatomy, and therapeutics