[PDF] Statistical Methods For Locating Quantitative Trait Loci With Molecular Markers eBook

Author : Rongling Wu
Publisher : Springer Science & Business Media
Page : 371 pages
File Size : 35,89 MB
Release : 2007-07-17
Category : Science
ISBN : 038768154X

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This book introduces the basic concepts and methods that are useful in the statistical analysis and modeling of the DNA-based marker and phenotypic data that arise in agriculture, forestry, experimental biology, and other fields. It concentrates on the linkage analysis of markers, map construction and quantitative trait locus (QTL) mapping, and assumes a background in regression analysis and maximum likelihood approaches. The strength of this book lies in the construction of general models and algorithms for linkage analysis, as well as in QTL mapping in any kind of crossed pedigrees initiated with inbred lines of crops.

Author : Nicola J. Camp
Publisher : Springer Science & Business Media
Page : 362 pages
File Size : 11,88 MB
Release : 2008-02-03
Category : Medical
ISBN : 1592591760

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In Quantitative Trait Loci: Methods and Protocols, a panel of highly experienced statistical geneticists demonstrate in a step-by-step fashion how to successfully analyze quantitative trait data using a variety of methods and software for the detection and fine mapping of quantitative trait loci (QTL). Writing for the nonmathematician, these experts guide the investigator from the design stage of a project onwards, providing detailed explanations of how best to proceed with each specific analysis, to find and use appropriate software, and to interpret results. Worked examples, citations to key papers, and variations in method ease the way to understanding and successful studies. Among the cutting-edge techniques presented are QTDT methods, variance components methods, and the Markov Chain Monte Carlo method for joint linkage and segregation analysis.

Author : Joel Ira Weller
Publisher : CABI
Page : 288 pages
File Size : 10,31 MB
Release : 2009
Category : Technology & Engineering
ISBN : 1845937341

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Quantitative Trait Loci (QTL) is a topic of major agricultural significance for efficient livestock production. This book covers various statistical methods that have been used or proposed for detection and analysis of QTL and marker-and gene-assisted selection in animal genetics and breeding.

Author : M.C. Yang
Publisher : CRC Press
Page : 264 pages
File Size : 24,46 MB
Release : 2000-02-23
Category : Mathematics
ISBN : 9789056991340

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Although the basic statistical theory behind modern genetics is not very difficult, most statistical genetics papers are not easy to read for beginners in the field, and formulae quickly become very tedious to fit a particular area of application. Introduction to Statistical Methods in Modern Genetics distinguishes between the necessary and unnecessary complexity in a presentation designed for graduate-level statistics students. The author keeps derivations simple, but does so without losing the mathematical details. He also provides the required background in modern genetics for those looking forward to entering this arena. Along with some of the statistical tools important in genetics applications, students will learn: How a gene is found How scientists have separated the genetic and environmental aspects of a person's intelligence How genetics are used in agriculture to improve crops and domestic animals What a DNA fingerprint is and why there are controversies about it Although the author assumes students have a foundation in basic statistics, an appendix provides the necessary background beyond the elementary, including multinomial distributions, inference on frequency tables, and discriminant analysis. With clear explanations, a multitude of figures, and exercise sets in each chapter, this text forms an outstanding entrée into the rapidly expanding world of genetic data analysis.

Author : Andreas Baierl
Publisher : Sudwestdeutscher Verlag Fur Hochschulschriften AG
Page : 96 pages
File Size : 48,46 MB
Release : 2008
Category :
ISBN : 9783838101224

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Recent technological advances in genetics pose new challenging problems to statistical methodology. The genetic technique of QTL mapping deals with locating genes that influence a quantitative character of an organism. Within the statistical framework of model selection, existing approaches are adapted and modifed: The search for genetic effects is extended to interactions between genes (i.e. epistatsis), while taking computational performance into account. Robust statistical methods are included in order to cope with quantitative effects that have heavy-tailed distribution or outliers. The performance and applicability of all methods is assessed by extensive simulation studies and the reanalysis of previously published genetic data sets.

Author : Karl W. Broman
Publisher : Springer Science & Business Media
Page : 401 pages
File Size : 28,98 MB
Release : 2009-07-21
Category : Science
ISBN : 0387921257

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Comprehensive discussion of QTL mapping concepts and theory Detailed instructions on the use of the R/qtl software, the most featured and flexible software for QTL mapping Two case studies illustrate QTL analysis in its entirety