[PDF] Single Neuron Computation In Vivo eBook

Author : Thomas M. McKenna
Publisher : Academic Press
Page : 663 pages
File Size : 41,4 MB
Release : 2014-05-19
Category : Computers
ISBN : 1483296067

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This book contains twenty-two original contributions that provide a comprehensive overview of computational approaches to understanding a single neuron structure. The focus on cellular-level processes is twofold. From a computational neuroscience perspective, a thorough understanding of the information processing performed by single neurons leads to an understanding of circuit- and systems-level activity. From the standpoint of artificial neural networks (ANNs), a single real neuron is as complex an operational unit as an entire ANN, and formalizing the complex computations performed by real neurons is essential to the design of enhanced processor elements for use in the next generation of ANNs.The book covers computation in dendrites and spines, computational aspects of ion channels, synapses, patterned discharge and multistate neurons, and stochastic models of neuron dynamics. It is the most up-to-date presentation of biophysical and computational methods.

Author : Wulfram Gerstner
Publisher : Cambridge University Press
Page : 591 pages
File Size : 47,35 MB
Release : 2014-07-24
Category : Computers
ISBN : 1107060834

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This solid introduction uses the principles of physics and the tools of mathematics to approach fundamental questions of neuroscience.

Author : Itzhak Fried
Publisher : MIT Press
Page : 391 pages
File Size : 30,36 MB
Release : 2014-06-13
Category : Science
ISBN : 0262324008

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Foundational studies of the activities of spiking neurons in the awake and behaving human brain and the insights they yield into cognitive and clinical phenomena. In the last decade, the synergistic interaction of neurosurgeons, engineers, and neuroscientists, combined with new technologies, has enabled scientists to study the awake, behaving human brain directly. These developments allow cognitive processes to be characterized at unprecedented resolution: single neuron activity. Direct observation of the human brain has already led to major insights into such aspects of brain function as perception, language, sleep, learning, memory, action, imagery, volition, and consciousness. In this volume, experts document the successes, challenges, and opportunity in an emerging field. The book presents methodological tutorials, with chapters on such topics as the surgical implantation of electrodes and data analysis techniques; describes novel insights into cognitive functions including memory, decision making, and visual imagery; and discusses insights into diseases such as epilepsy and movement disorders gained from examining single neuron activity. Finally, contributors consider future challenges, questions that are ripe for investigation, and exciting avenues for translational efforts. Contributors Ralph Adolphs, William S. Anderson, Arjun K. Bansal, Eric J. Behnke, Moran Cerf, Jonathan O. Dostrovsky, Emad N. Eskandar, Tony A. Fields, Itzhak Fried, Hagar Gelbard-Sagiv, C. Rory Goodwin, Clement Hamani, Chris Heller, Mojgan Hodaie, Matthew Howard III, William D. Hutchison, Matias Ison, Hiroto Kawasaki, Christof Koch, Rüdiger Köhling, Gabriel Kreiman, Michel Le Van Quyen, Frederick A. Lenz, Andres M. Lozano, Adam N. Mamelak, Clarissa Martinez-Rubio, Florian Mormann, Yuval Nir, George Ojemann, Shaun R. Patel, Sanjay Patra, Linda Philpott, Rodrigo Quian Quiroga, Ian Ross, Ueli Rutishauser, Andreas Schulze-Bonhage, Erin M. Schuman, Demetrio Sierra-Mercado, Richard J. Staba, Nanthia Suthana, William Sutherling, Travis S. Tierney, Giulio Tononi, Oana Tudusciuc, Charles L. Wilson

Author : Hermann Cuntz
Publisher : Springer Science & Business Media
Page : 519 pages
File Size : 10,51 MB
Release : 2013-11-23
Category : Medical
ISBN : 1461480949

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Neuronal dendritic trees are complex structures that endow the cell with powerful computing capabilities and allow for high neural interconnectivity. Studying the function of dendritic structures has a long tradition in theoretical neuroscience, starting with the pioneering work by Wilfrid Rall in the 1950s. Recent advances in experimental techniques allow us to study dendrites with a new perspective and in greater detail. The goal of this volume is to provide a résumé of the state-of-the-art in experimental, computational, and mathematical investigations into the functions of dendrites in a variety of neural systems. The book first looks at morphological properties of dendrites and summarizes the approaches to measure dendrite morphology quantitatively and to actually generate synthetic dendrite morphologies in computer models. This morphological characterization ranges from the study of fractal principles to describe dendrite topologies, to the consequences of optimization principles for dendrite shape. Individual approaches are collected to study the aspects of dendrite shape that relate directly to underlying circuit constraints and computation. The second main theme focuses on how dendrites contribute to the computations that neurons perform. What role do dendritic morphology and the distributions of synapses and membrane properties over the dendritic tree have in determining the output of a neuron in response to its input? A wide range of studies is brought together, with topics ranging from general to system-specific phenomena—some having a strong experimental component, and others being fully theoretical. The studies come from many different neural systems and animal species ranging from invertebrates to mammals. With this broad focus, an overview is given of the diversity of mechanisms that dendrites can employ to shape neural computations.

Author : Peter Dayan
Publisher : MIT Press
Page : 477 pages
File Size : 44,28 MB
Release : 2005-08-12
Category : Medical
ISBN : 0262541858

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Theoretical neuroscience provides a quantitative basis for describing what nervous systems do, determining how they function, and uncovering the general principles by which they operate. This text introduces the basic mathematical and computational methods of theoretical neuroscience and presents applications in a variety of areas including vision, sensory-motor integration, development, learning, and memory. The book is divided into three parts. Part I discusses the relationship between sensory stimuli and neural responses, focusing on the representation of information by the spiking activity of neurons. Part II discusses the modeling of neurons and neural circuits on the basis of cellular and synaptic biophysics. Part III analyzes the role of plasticity in development and learning. An appendix covers the mathematical methods used, and exercises are available on the book's Web site.

Author : Amir Zjajo
Publisher : CRC Press
Page : 265 pages
File Size : 32,8 MB
Release : 2022-09-01
Category : Science
ISBN : 1000793524

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Simulation of brain neurons in real-time using biophysically-meaningful models is a pre-requisite for comprehensive understanding of how neurons process information and communicate with each other, in effect efficiently complementing in-vivo experiments. In spiking neural networks (SNNs), propagated information is not just encoded by the firing rate of each neuron in the network, as in artificial neural networks (ANNs), but, in addition, by amplitude, spike-train patterns, and the transfer rate. The high level of realism of SNNs and more significant computational and analytic capabilities in comparison with ANNs, however, limit the size of the realized networks. Consequently, the main challenge in building complex and biophysically-accurate SNNs is largely posed by the high computational and data transfer demands.Real-Time Multi-Chip Neural Network for Cognitive Systems presents novel real-time, reconfigurable, multi-chip SNN system architecture based on localized communication, which effectively reduces the communication cost to a linear growth. The system use double floating-point arithmetic for the most biologically accurate cell behavior simulation, and is flexible enough to offer an easy implementation of various neuron network topologies, cell communication schemes, as well as models and kinds of cells. The system offers a high run-time configurability, which reduces the need for resynthesizing the system. In addition, the simulator features configurable on- and off-chip communication latencies as well as neuron calculation latencies. All parts of the system are generated automatically based on the neuron interconnection scheme in use. The simulator allows exploration of different system configurations, e.g. the interconnection scheme between the neurons, the intracellular concentration of different chemical compounds (ions), which affect how action potentials are initiated and propagate.

Author : Wulfram Gerstner
Publisher : Cambridge University Press
Page : 498 pages
File Size : 14,24 MB
Release : 2002-08-15
Category : Computers
ISBN : 9780521890793

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Neurons in the brain communicate by short electrical pulses, the so-called action potentials or spikes. How can we understand the process of spike generation? How can we understand information transmission by neurons? What happens if thousands of neurons are coupled together in a seemingly random network? How does the network connectivity determine the activity patterns? And, vice versa, how does the spike activity influence the connectivity pattern? These questions are addressed in this 2002 introduction to spiking neurons aimed at those taking courses in computational neuroscience, theoretical biology, biophysics, or neural networks. The approach will suit students of physics, mathematics, or computer science; it will also be useful for biologists who are interested in mathematical modelling. The text is enhanced by many worked examples and illustrations. There are no mathematical prerequisites beyond what the audience would meet as undergraduates: more advanced techniques are introduced in an elementary, concrete fashion when needed.