[PDF] Restricted Data eBook

Author : Alex Wellerstein
Publisher : University of Chicago Press
Page : 558 pages
File Size : 14,71 MB
Release : 2021-04-09
Category : History
ISBN : 022602038X

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"Nuclear weapons, since their conception, have been the subject of secrecy. In the months after the dropping of the atomic bombs on Hiroshima and Nagasaki, the American scientific establishment, the American government, and the American public all wrestled with what was called the "problem of secrecy," wondering not only whether secrecy was appropriate and effective as a means of controlling this new technology but also whether it was compatible with the country's core values. Out of a messy context of propaganda, confusion, spy scares, and the grave counsel of competing groups of scientists, what historian Alex Wellerstein calls a "new regime of secrecy" was put into place. It was unlike any other previous or since. Nuclear secrets were given their own unique legal designation in American law ("restricted data"), one that operates differently than all other forms of national security classification and exists to this day. Drawing on massive amounts of declassified files, including records released by the government for the first time at the author's request, Restricted Data is a narrative account of nuclear secrecy and the tensions and uncertainty that built as the Cold War continued. In the US, both science and democracy are pitted against nuclear secrecy, and this makes its history uniquely compelling and timely"--

Author : Institute of Medicine
Publisher : National Academies Press
Page : 236 pages
File Size : 48,16 MB
Release : 2015-04-20
Category : Medical
ISBN : 0309316324

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Data sharing can accelerate new discoveries by avoiding duplicative trials, stimulating new ideas for research, and enabling the maximal scientific knowledge and benefits to be gained from the efforts of clinical trial participants and investigators. At the same time, sharing clinical trial data presents risks, burdens, and challenges. These include the need to protect the privacy and honor the consent of clinical trial participants; safeguard the legitimate economic interests of sponsors; and guard against invalid secondary analyses, which could undermine trust in clinical trials or otherwise harm public health. Sharing Clinical Trial Data presents activities and strategies for the responsible sharing of clinical trial data. With the goal of increasing scientific knowledge to lead to better therapies for patients, this book identifies guiding principles and makes recommendations to maximize the benefits and minimize risks. This report offers guidance on the types of clinical trial data available at different points in the process, the points in the process at which each type of data should be shared, methods for sharing data, what groups should have access to data, and future knowledge and infrastructure needs. Responsible sharing of clinical trial data will allow other investigators to replicate published findings and carry out additional analyses, strengthen the evidence base for regulatory and clinical decisions, and increase the scientific knowledge gained from investments by the funders of clinical trials. The recommendations of Sharing Clinical Trial Data will be useful both now and well into the future as improved sharing of data leads to a stronger evidence base for treatment. This book will be of interest to stakeholders across the spectrum of research-from funders, to researchers, to journals, to physicians, and ultimately, to patients.

Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
Page : 151 pages
File Size : 36,58 MB
Release : 2017-04-21
Category : Social Science
ISBN : 030945428X

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Federal government statistics provide critical information to the country and serve a key role in a democracy. For decades, sample surveys with instruments carefully designed for particular data needs have been one of the primary methods for collecting data for federal statistics. However, the costs of conducting such surveys have been increasing while response rates have been declining, and many surveys are not able to fulfill growing demands for more timely information and for more detailed information at state and local levels. Innovations in Federal Statistics examines the opportunities and risks of using government administrative and private sector data sources to foster a paradigm shift in federal statistical programs that would combine diverse data sources in a secure manner to enhance federal statistics. This first publication of a two-part series discusses the challenges faced by the federal statistical system and the foundational elements needed for a new paradigm.

Author : Alan L. Gustman
Publisher : Harvard University Press
Page : 404 pages
File Size : 27,16 MB
Release : 2010-05
Category : Business & Economics
ISBN : 9780674048669

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This book presents a careful analysis of pension data collected by the Health and Retirement Study, a unique survey of people over the age of fifty conducted by the University of Michigan for the National Institute on Aging. The authors studied pensions as they evolve over individuals’ work lives and into retirement: how pension coverage and plans change over a lifetime, how many pensions workers have by the time they retire and what these pensions are worth, what pensions contribute to individual retirement incomes, and how trends and policy changes affect retirement plans. The book focuses on the major features of pensions, including plan type and participation, ages of eligibility for retirement, values of different pension types, how pension values are influenced by retirement age, how plans are settled when a worker leaves a firm, how well people understand their pensions, the importance of pensions in retirement saving and as a share of household wealth, and the vulnerability of the retirement age population to the current financial crisis. This book provides readers with an invaluable look at the crucial but ever-changing role of pensions in supporting retirees.

Author : Shawn Cole
Publisher : Abdul Latif Jameel Poverty Action Lab
Page : 618 pages
File Size : 49,24 MB
Release : 2021
Category :
ISBN : 9781736021606

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This Handbook intends to inform Data Providers and researchers on how to provide privacy-protected access to, handle, and analyze administrative data, and to link them with existing resources, such as a database of data use agreements (DUA) and templates. Available publicly, the Handbook will provide guidance on data access requirements and procedures, data privacy, data security, property rights, regulations for public data use, data architecture, data use and storage, cost structure and recovery, ethics and privacy-protection, making data accessible for research, and dissemination for restricted access use. The knowledge base will serve as a resource for all researchers looking to work with administrative data and for Data Providers looking to make such data available.

Author : Agency for Healthcare Research and Quality/AHRQ
Publisher : Government Printing Office
Page : 396 pages
File Size : 35,6 MB
Release : 2014-04-01
Category : Medical
ISBN : 1587634333

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This User’s Guide is intended to support the design, implementation, analysis, interpretation, and quality evaluation of registries created to increase understanding of patient outcomes. For the purposes of this guide, a patient registry is an organized system that uses observational study methods to collect uniform data (clinical and other) to evaluate specified outcomes for a population defined by a particular disease, condition, or exposure, and that serves one or more predetermined scientific, clinical, or policy purposes. A registry database is a file (or files) derived from the registry. Although registries can serve many purposes, this guide focuses on registries created for one or more of the following purposes: to describe the natural history of disease, to determine clinical effectiveness or cost-effectiveness of health care products and services, to measure or monitor safety and harm, and/or to measure quality of care. Registries are classified according to how their populations are defined. For example, product registries include patients who have been exposed to biopharmaceutical products or medical devices. Health services registries consist of patients who have had a common procedure, clinical encounter, or hospitalization. Disease or condition registries are defined by patients having the same diagnosis, such as cystic fibrosis or heart failure. The User’s Guide was created by researchers affiliated with AHRQ’s Effective Health Care Program, particularly those who participated in AHRQ’s DEcIDE (Developing Evidence to Inform Decisions About Effectiveness) program. Chapters were subject to multiple internal and external independent reviews.

Author : Alex Wellerstein
Publisher : University of Chicago Press
Page : 558 pages
File Size : 40,30 MB
Release : 2021-04-09
Category : History
ISBN : 022602041X

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The first full history of US nuclear secrecy, from its origins in the late 1930s to our post–Cold War present. The American atomic bomb was born in secrecy. From the moment scientists first conceived of its possibility to the bombings of Hiroshima and Nagasaki and beyond, there were efforts to control the spread of nuclear information and the newly discovered scientific facts that made such powerful weapons possible. The totalizing scientific secrecy that the atomic bomb appeared to demand was new, unusual, and very nearly unprecedented. It was foreign to American science and American democracy—and potentially incompatible with both. From the beginning, this secrecy was controversial, and it was always contested. The atomic bomb was not merely the application of science to war, but the result of decades of investment in scientific education, infrastructure, and global collaboration. If secrecy became the norm, how would science survive? Drawing on troves of declassified files, including records released by the government for the first time through the author’s efforts, Restricted Data traces the complex evolution of the US nuclear secrecy regime from the first whisper of the atomic bomb through the mounting tensions of the Cold War and into the early twenty-first century. A compelling history of powerful ideas at war, it tells a story that feels distinctly American: rich, sprawling, and built on the conflict between high-minded idealism and ugly, fearful power.

Author : National Research Council
Publisher : National Academies Press
Page : 163 pages
File Size : 18,97 MB
Release : 2010-12-21
Category : Medical
ISBN : 030918651X

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Randomized clinical trials are the primary tool for evaluating new medical interventions. Randomization provides for a fair comparison between treatment and control groups, balancing out, on average, distributions of known and unknown factors among the participants. Unfortunately, these studies often lack a substantial percentage of data. This missing data reduces the benefit provided by the randomization and introduces potential biases in the comparison of the treatment groups. Missing data can arise for a variety of reasons, including the inability or unwillingness of participants to meet appointments for evaluation. And in some studies, some or all of data collection ceases when participants discontinue study treatment. Existing guidelines for the design and conduct of clinical trials, and the analysis of the resulting data, provide only limited advice on how to handle missing data. Thus, approaches to the analysis of data with an appreciable amount of missing values tend to be ad hoc and variable. The Prevention and Treatment of Missing Data in Clinical Trials concludes that a more principled approach to design and analysis in the presence of missing data is both needed and possible. Such an approach needs to focus on two critical elements: (1) careful design and conduct to limit the amount and impact of missing data and (2) analysis that makes full use of information on all randomized participants and is based on careful attention to the assumptions about the nature of the missing data underlying estimates of treatment effects. In addition to the highest priority recommendations, the book offers more detailed recommendations on the conduct of clinical trials and techniques for analysis of trial data.

Author : Julian P. T. Higgins
Publisher : Wiley
Page : 672 pages
File Size : 46,38 MB
Release : 2008-11-24
Category : Medical
ISBN : 9780470699515

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Healthcare providers, consumers, researchers and policy makers are inundated with unmanageable amounts of information, including evidence from healthcare research. It has become impossible for all to have the time and resources to find, appraise and interpret this evidence and incorporate it into healthcare decisions. Cochrane Reviews respond to this challenge by identifying, appraising and synthesizing research-based evidence and presenting it in a standardized format, published in The Cochrane Library (www.thecochranelibrary.com). The Cochrane Handbook for Systematic Reviews of Interventions contains methodological guidance for the preparation and maintenance of Cochrane intervention reviews. Written in a clear and accessible format, it is the essential manual for all those preparing, maintaining and reading Cochrane reviews. Many of the principles and methods described here are appropriate for systematic reviews applied to other types of research and to systematic reviews of interventions undertaken by others. It is hoped therefore that this book will be invaluable to all those who want to understand the role of systematic reviews, critically appraise published reviews or perform reviews themselves.