[PDF] Renal Fibrosis Mechanisms And Therapies eBook

Author : Bi-Cheng Liu
Publisher : Springer
Page : 709 pages
File Size : 36,74 MB
Release : 2019-08-09
Category : Science
ISBN : 9811388717

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This book systemically presents the latest research on renal fibrosis, covering all the major topics in the field, including the possible mechanisms, biomarkers, and strategies for prevention and treatment of chronic kidney disease (CKD). Due to its high prevalence, CKD represents a huge global economic and social burden. Irrespective of the initial causes, CKD progresses to end stage kidney disease (ESKD) due to renal fibrosis, which is characterized by glomerulosclerosis, tubule atrophy and atresia, and the excessive accumulation of extracellular matrix (ECM) in the kidney. Unfortunately, an estimated 1%-2% of the adult population living with CKD will need renal replacement therapy at some point as a result of ESKD. As such, strategies for preventing or slowing CKD progression to ESKD are of utmost importance, and studies aiming to understand the mechanisms of renal fibrosis have been the focus of intensive research. Recently, novel insights into the pathophysiological processes have furthered our understanding of the pathogenesis of renal fibrosis, and more importantly, promoted studies on the early diagnosis and treatment of CKD. This book draws lessons from the extensive, state-of-the-art research in this field, elaborating the new theories and new techniques to offer readers a detailed and comprehensive understanding of renal fibrosis and as well as inspiration for future research directions.

Author : Bi-Cheng Liu
Publisher : Springer
Page : 709 pages
File Size : 40,42 MB
Release : 2019-08-24
Category : Science
ISBN : 9789811388705

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This book systemically presents the latest research on renal fibrosis, covering all the major topics in the field, including the possible mechanisms, biomarkers, and strategies for prevention and treatment of chronic kidney disease (CKD). Due to its high prevalence, CKD represents a huge global economic and social burden. Irrespective of the initial causes, CKD progresses to end stage kidney disease (ESKD) due to renal fibrosis, which is characterized by glomerulosclerosis, tubule atrophy and atresia, and the excessive accumulation of extracellular matrix (ECM) in the kidney. Unfortunately, an estimated 1%-2% of the adult population living with CKD will need renal replacement therapy at some point as a result of ESKD. As such, strategies for preventing or slowing CKD progression to ESKD are of utmost importance, and studies aiming to understand the mechanisms of renal fibrosis have been the focus of intensive research. Recently, novel insights into the pathophysiological processes have furthered our understanding of the pathogenesis of renal fibrosis, and more importantly, promoted studies on the early diagnosis and treatment of CKD. This book draws lessons from the extensive, state-of-the-art research in this field, elaborating the new theories and new techniques to offer readers a detailed and comprehensive understanding of renal fibrosis and as well as inspiration for future research directions.

Author : Hui Y. Lan
Publisher : Frontiers Media SA
Page : 84 pages
File Size : 26,76 MB
Release : 2018-07-26
Category :
ISBN : 2889454991

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Scarring of the glomerular and tubulointerstitial compartments is a hallmark of progressive kidney disease. Renal fibrosis involves a complex interplay between kidney cells, leukocytes and fibroblasts in which transforming growth factor-β (TGF-β) plays a key role. This eBook provides a comprehensive update on TGF-β signalling pathways and introduces a range of cellular and molecular mechanisms involved in renal fibrosis both upstream and downstream of TGF-β. The wide variety of potential new targets described herein bodes well for the future development of effective therapies to tackle the major clinical problem of progressive renal fibrosis.

Author : Mohammed S. Razzaque
Publisher : Karger Medical and Scientific Publishers
Page : 222 pages
File Size : 26,99 MB
Release : 2003-01-01
Category : Medical
ISBN : 3805575688

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This publication provides a synopsis of the rapid progress made in the field of renal cell biology during the last decade, progress which has resulted in a better conceptual understanding of the cellular and molecular mechanisms of fibrotic renal disease. These developments have provided new therapeutic choices and led to the discovery of gene-based therapeutic options. The topics covered in this book have been carefully selected from the immense number of aspects of the disease to provide essential information on the molecular basis of renal fibrosis. Individual chapters discuss topics such as proteinuria and tubulointerstitial injury, the roles and regulation of TGF-beta, chemokines, oxidant stress, matrix remodeling, significance of renal expression of NF-kappa, and the potential impact of cell death in renal fibrosis.Written so as to present the complex information as simply as possible, this publication will be a very useful tool for general health professionals involved in the fields of immunology and cell biology, as well as for clinicians and researchers within the fields of nephrology, pathology and matrix biology.

Author : Michael S. Goligorsky
Publisher : Academic Press
Page : 473 pages
File Size : 34,39 MB
Release : 2010-11-26
Category : Science
ISBN : 0123809290

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Progression of chronic diseases in general and chronic kidney disease in particular has been traditionally viewed in the light of various contributors to development of glomerulosclerosis and tubulointerstitial scarring culminating in renal fibrosis. Indeed, this dogma prevailed for decades underscoring experimental attempts to halt fibrotic processes. Breakthrough investigations of the past few years on stem/progenitor cell involvement in organ regeneration caused a conceptual shift in tackling the mechanisms of nephrosclerosis. It has become clear that the rate of progression of chronic kidney disease is the net sum of the opposing trends: degenerative fibrotic processes and regenerative repair mechanisms. The latter part of this equation has been by and large ignored for years and only recently attracted investigative attention. This book revisits the problem of kidney disease by focusing on regenerative mechanisms in renal repair and on the ways these regenerative processes can become subverted by an intrinsic disease process eventuating in its progression. Cutting-edge investigations are summarized by the most experienced international team of experts. Presents a comprehensive, translational source for all aspects of renal stem cells, tissue regeneration, and stem cell therapies for renal diseases in one reference work. This will ultimately result in time savings for academic, medical and pharma researchers Experts in the renal stem cell system in kidney repair and regeneration take readers from the bench research to new therapeutic approaches, providing a common language for nephrology researchers, fellows and other stem cell researchers. This enables the discussion of development of stem cells and their use in the repair and regeneration of the kidney

Author : Xin J. Zhou
Publisher : Cambridge University Press
Page : 691 pages
File Size : 50,3 MB
Release : 2017-03-02
Category : Medical
ISBN : 1316613984

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An algorithmic approach to interpreting renal pathology, updated in light of recent advances in understanding and new classification schemes.

Author : Patrick C. Baer
Publisher : MDPI
Page : 496 pages
File Size : 20,98 MB
Release : 2020-04-03
Category : Medical
ISBN : 3039285386

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Acute kidney injury (AKI) is still associated with high morbidity and mortality incidence rates, and also bears an elevated risk of subsequent chronic kidney disease. Although the kidney has a remarkable capacity for regeneration after injury and may recover completely depending on the type of renal lesions, the options for clinical intervention are restricted to fluid management and extracorporeal kidney support. The development of novel therapies to prevent AKI, to improve renal regeneration capacity after AKI, and to preserve renal function is urgently needed. The Special Issue covers research articles that investigated the molecular mechanisms of inflammation and injury during different renal pathologies, renal regeneration, diagnostics using new biomarkers, and the effects of different stimuli like medication or bacterial components on isolated renal cells or in vivo models. The Special Issue contains important reviews that consider the current knowledge of cell death and regeneration, inflammation, and the molecular mechanisms of kidney diseases. In addition, the potential of cell-based therapy approaches that use mesenchymal stromal/stem cells or their derivates is summarized. This edition is complemented by reviews that deal with the current data situation on other specific topics like diabetes and diabetic nephropathy or new therapeutic targets.

Author : Haruki Yamada
Publisher : CRC Press
Page : 250 pages
File Size : 17,57 MB
Release : 2005-04-29
Category : Health & Fitness
ISBN : 9781420023510

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Kampo is a traditional Japanese herbal medicine that takes a holistic approach to healing. Since Kampo is currently being used for the treatment of a wide range of diseases with many reports of clinical effectiveness, it is playing an increasingly important role in Japan's modern-day health care. Juzen-taiho-to (Shi-Quan-Da-Bu-Tang): Scientific Evaluation and Clinical Applications presents a concise overview of the important Kampo formula of Juzen-taiho-to. The book describes the therapeutic indications and traditional uses of Juzen-taiho-to, followed by its taxonomy, cultivation, quality assurance, and chemical constituents and pharmacological actions of raw plant material as the component herbs. Experts in the field discuss up-to-date findings and topics associated with the pharmacology and clinical application of Juzen-taiho-to, including its important immunomodulating, anti-tumor, and anti-metastatic properties, toxicology and side effects, and other related formulations. Today, Kampo medicine is steadily gaining acceptance by Japan's national health insurance system, the medical community, and contemporary society. This book provides a comprehensive review of Juzen-taiho-to and demonstrates how Kampo and other herbal medicines are becoming the popular, practical, and preferred treatments of tomorrow.