[PDF] Recent Advancements In Biomarkers And Early Detection Of Gastrointestinal Cancers eBook

Author : Pallaval Veera Bramhachari
Publisher : Springer Nature
Page : 238 pages
File Size : 46,57 MB
Release : 2020-07-21
Category : Medical
ISBN : 981154431X

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This book describes various novel biomarkers for the early diagnosis of gastrointestinal (GI) cancers. It also highlights recent advances in understanding the role of molecular markers and biomarkers, such as volatile biomarkers, serum biomarkers, predictive and prognostic molecular markers for the early detection of GI cancers. Further, it discusses novel biomarkers, including circulating microRNAs, serum microRNA and plasma microRNA in GI cancer. The book presents breakthrough technologies like ultra-sensitive nano-chips, nanosensors, nanodevices, biosensors, electrochemical biosensors, optical biosensors, DNA biosensors, synthetic biology devices, and 'omics' technologies for the early diagnosis of gastrointestinal cancer. In addition it examines the potential of genome-wide association studies, big data analytics, computation biology, systems biology, and nanotechnology for early diagnostics and therapeutics for gastrointestinal cancer, with a focus on personalized cancer treatment. The book is a valuable source for researchers and clinicians engaged in detection and diagnosis of gastrointestinal cancers.

Author : Mikhael Kular
Publisher : American Medical Publishers
Page : 0 pages
File Size : 40,23 MB
Release : 2023-09-19
Category : Health & Fitness
ISBN :

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A biomarker is a biological molecule present in the blood, other body fluids or tissues, that indicates normal or abnormal process, condition or a disease. It can act as an alternative tool and is helpful in selecting accurate treatment in various diseases. Gastrointestinal cancer is a malignant condition affecting gastrointestinal tract and organs of the digestive system including the stomach, pancreas, esophagus, small and large intestine, biliary system, rectum and anus. In the case of esophageal cancer, methylation of DNA can be used as a biomarker for early detection because methylation patterns appear in the initial stages. Protein biomarkers are utilized as markers for gastric tumor for effective diagnosis, prognosis and checking for recurrence of cancer after treatment. Various biomarkers that are utilized in case of stomach cancer include antigens like CA12-5 and CA72-4 as well as alpha-fetoprotein. This book provides comprehensive insights on biomarkers. The topics covered herein deal with the core aspects of the detection of gastrointestinal cancers through biomarkers. This book will serve as a reference to a broad spectrum of readers.

Author : Zequn Li
Publisher : Frontiers Media SA
Page : 467 pages
File Size : 12,58 MB
Release : 2023-11-17
Category : Medical
ISBN : 2832538983

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Significant changes in diet, environment, and population increase gastrointestinal cancer morbidity. A growing number of novel biomarkers and underlying mechanisms are being elucidated, some of which may even conflict with assumptions of past decades. Therefore, collecting recent findings on novel diagnostic/prognostic factors, biomarkers, and/or risk factors in gastrointestinal cancers is a prerequisite for a better understanding of the disease. Despite remarkable progressions in surgical treatments and chemotherapies, the prognosis of gastrointestinal cancer is far from satisfactory due to the high occurrence of drug resistance. Based on the identification of novel biomarkers as well as their underlying mechanisms, targeted drug development will provide significant complementary therapeutic effects to conventional chemoradiotherapies. High-throughput methods such as next-generation sequencing on RNA level and mass spectrometry on protein/lipid/metabolite level serve as efficient strategies for biomarker identification and drug development. This Research Topic aims at presenting recent advances on gastrointestinal cancer biomarkers and their underlying functional mechanisms, providing a better understanding of carcinogenesis, tumor progression, tumor relapse, as well as drug resistance. This will subsequently contribute to the development of novel therapeutic interventions targeting gastrointestinal cancers, thus improving patients' outcomes.

Author : Sudhir Srivastava
Publisher : John Wiley & Sons
Page : 494 pages
File Size : 25,84 MB
Release : 2017-06-07
Category : Medical
ISBN : 1118468821

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Prepared by world leaders on this topic, Biomarkers in Cancer Screening and Early Detection offers a comprehensive, state-of-the-art perspective on the various research and clinical aspects of cancer biomarkers, from their discovery and development to their validation, clinical utility, and use in developing personalized cancer treatment. Offers a comprehensive, state-of-the-art perspective on the various research and clinical aspects of cancer biomarkers Provides immediately actionable information and hopefully also inspiration to move discovery and clinical application forward Offers vital knowledge to help develop personalized cancer treatment for individual patients with specific cancers

Author : Daxiang Cui
Publisher : Springer
Page : 361 pages
File Size : 50,50 MB
Release : 2017-06-21
Category : Medical
ISBN : 9402409513

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The book explores recent developments in the application of nanotechnology in the early detection of gastric cancer. It discusses various aspects, such as screening for gastric cancer-associated biomarkers; establishing new ultrasensitive detection methods based on nanoparticle labeling and nanoeffects; developing a new generation of nanodevices for high-throughput examination of serum and breath biomarkers; developing multifunctional nanoprobes for targeted imaging and simultaneous therapy of gastric cancer; evaluating the biosafety of multifunctional nanoprobes; and the establishment of a pre-warning and early diagnosis system. It also presents clinical applications and prospects. The book provides a valuable reference for researchers in nanomedicine and clinicians involved in gastric cancer and radiology.

Author : Fay Kastrinos
Publisher : Elsevier Health Sciences
Page : 201 pages
File Size : 11,49 MB
Release : 2021-11-26
Category : Medical
ISBN : 0323849598

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This issue of Gastrointestinal Endoscopy Clinics provides a multidisciplinary approach to the evaluation and care of individuals with inherited gastrointestinal cancer conditions. With the many recent advances made in genomic medicine and the potential impact on medical management, the articles in this issue disseminate new knowledge on the identification and management of individuals and families with a genetic susceptibility to the development of gastrointestinal cancers, including the genetic basis and cancer risks associated with inherited cancer syndromes and integrated familial cancer risk assessment; genetic testing approaches; and incorporating genetic risk counseling into routine medical care. The goal is to improve detection of GI cancer syndromes, understand related cancer risks, and optimize strategies for the prevention and early detection of cancers to minimize morbidity and mortality. Integrating genetic assessment into gastrointestinal cancer care is highly relevant across the cancer care spectrum and gastroenterologists will come away with the most current evidence to enhance and improve their clinical practice. Provides in-depth, clinical reviews on Inherited GI Cancers: Identification, Management and the Role of Genetic Evaluation and Testing, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field; Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews. Contains 11 relevant, practice-oriented topics including Defining High-Risk Individuals for Pancreatic Cancer and the Role of Genetic Testing; Endoscopic Management and Surgical Consideration for FAP-Related Polyposis; Genetic Syndromes Associated with Gastric Cancer; Screening and Surgical Considerations in Hereditary Diffuse Gastric Cancer; and more.

Author : Marta Davila
Publisher : Elsevier Health Sciences
Page : 241 pages
File Size : 17,47 MB
Release : 2022-09-25
Category : Medical
ISBN : 032385012X

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In this issue of Diagnosis and Treatment of Gastrointestinal Cancers, guest editors Drs. Marta Davila and Raquel E. Davila bring their considerable expertise to the topic of Diagnosis and Treatment of Gastrointestinal Cancers. The early detection, diagnosis, and accurate staging of GI cancers, along with enhanced imaging techniques, new therapies, and a greater understanding of GI tumors at the molecular level, has revolutionized the approach to GI cancer patients in recent years. In this issue, distinguished authors recognized internationally as leading authorities in the field provide an exhaustive review of the latest topics in GI cancer. Contains 13 practice-oriented topics including management of Barrett’s esophagus and early esophageal adenocarcinoma; familial pancreatic cancer; colorectal cancer: screening and early detection; the microbiome in gastrointestinal cancers; and more. Provides in-depth clinical reviews on diagnosis and treatment of gastrointestinal cancers, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Author : Takaya Shimura
Publisher :
Page : 0 pages
File Size : 13,52 MB
Release : 2022
Category :
ISBN : 9783036549323

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Gastrointestinal (GI) cancer is a major cause of morbidity and mortality in the world. Since early diagnosis and optimal treatment selection are crucial to improving the prognosis of these diseases, the discovery of useful biomarkers has the potential to greatly reduce their burden. Recent technical and mechanical developments have allowed for the detection of tiny differences in various factors modified in physical conditions, which could contribute to the discovery of novel biomarkers for some diseases.In this Special Issue, we aim to focus on novel biomarkers for GI cancers, including esophageal cancer, gastric cancer, colorectal cancer, liver cancer, pancreatic cancer and biliary cancer. In addition, any samples (tissue, blood, urine and feces) are useful as biomarker sources, although body-fluid-based biomarkers are promising as diagnostic biomarkers due to their noninvasiveness. This Special Issue aims to collect novel insights clarifying the current situation and future perspective in this field.

Author : Ganji Purnachandra Nagaraju
Publisher : Springer Nature
Page : 259 pages
File Size : 33,47 MB
Release : 2020-10-01
Category : Medical
ISBN : 9811554714

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This book provides an up-to-date overview of gastrointestinal malignancies, including prevention, early detection, intervention, and life-extending therapeutics. It also assesses various biomarkers used for diagnostics, prognostics and prediction of response to chemoresistance. Further, it discusses the latest trends in the use of small-molecule targeted therapies and immunotherapies as single agents or combination with other treatments. Since resistance to radiation and chemotherapy contribute to the high recurrence and poor survival rates, improving the outcome for GI malignancies is dependent on the introduction of new biomarkers and therapeutic agents. Lastly, the book systematically investigates novel theranostics approaches using nanotechnology for the detection, diagnosis, and personalized treatment of GI malignancies.