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This book is a comprehensive resource providing the latest information on the diagnosis and management of thyroid disorders. Beginning with an overview of thyroid physiology and symptoms and evaluation of thyroid problems, the following chapters discuss many benign and malignant disorders and their medical and surgical management. Complete chapters are dedicated to ‘special circumstances’ including neonatal and junvenile thyrotoxicosis, and hyper and hypo-thyroidism in pregnancy. In depth coverage of topics such as Graves Disease, Hashimoto Disease, paediatric Graves, and sick euthyroid syndrome, is also provided. Key points Comprehensive resource providing latest information on diagnosis and management of thyroid disorders Covers numerous benign and malignant conditions Explains both medical and surgical management techniques Complete chapters dedicated to ‘special circumstances’
Thyroid Disease: A Case-Based and Practical Guide for Primary Care, by Dr. Emanuel Brams, is a supremely readable cased-based approach to understanding the myriad of disorders that encompass thyroid disease. Using cases derived from his busy practice, Dr. Brams gives us the history and physical examination details of each case, along with test results. Then, through a series of questions similar to that which any good clinician asks while caring for a patient, Dr. Brams explains an optimal approach to diagnosis, treatment, and follow-up of thyroid disease, with an emphasis on the practical and common issues that primary care physicians see in their offices. This is an important book for primary care physicians because thyroid disease is common in the population we take care of and accounts for 3–5% of primary care visits. It is often cited as an area that primary care phy- cians find confusing. Dr. Brams clarifies thyroid disease and, through his generous sharing of cases, allows us to join him in making clear diagnoses as well as share in the ambiguity and decisions about approach when the diagnoses and course of treatment are not clear. In this way, the book is honest, and deals directly with the issues of thyroid disease as they are seen by us as physicians, not as we sometimes may wish they were seen if patients presented with the clarity of walking textbooks. Dr.
Thyroid Diseases: Clinical Fundamentals and Therapy provides a wide-ranging examination of all clinically significant areas of thyroid diseases. Underlying physiological principles are closely linked to the clinical situation and practical therapeutic interventions. The book examines the clinical course, therapy, and final outcome of thyroid diseases, particularly the bimodal and transient evolution of several thyroid diseases. It also discusses the medical, surgical, and radiometabolic therapy of thyroid diseases, stressing the pros and cons of each therapeutic modality. More than 80 acknowledged experts from North America, Europe, and Japan have contributed to this exceptional reference volume, making it essential for physiologists, clinical endocrinologists, radiologists, researchers in nuclear medicine, oncologists, and radiotherapists.
Clinical Management of Thyroid Disease is an exciting new book edited by Fredric Wondisford, MD—developer of the revolutionary new drug, Thyrotropin—and Sally Radovick, MD, with contributions from experts in the field. It fulfills the niche of a succinct, clinical resource to help you translate research into practice. This full-color volume offers valuable information on thyroid cancer and non-cancerous lesions, the effect of drugs on thyroid function, genetic disorders, and more in an accessible, easy-to-read consistent format. Presents the expertise of authors and editorial staff comprised of leaders in the field of thyroid research and clinical management for the best-qualified guidance on diagnosis and treatment. Provides a full-color, comprehensive approach that makes valuable information easy to locate and quick to read. Covers relevant topics applicable to all levels of training and expertise to serve as a detailed clinical reference on everything from the basic to the sophisticated. Captures research advances on hot topics such as thyroid cancer and non-cancerous lesions, the effect of drugs on thyroid function, and genetic disorders so that you can incorporate them into the way you treat patients.
This book provides comprehensive knowledge about thyroid gland and highlights the recent trends in the management of thyroid dysfunctions. Thyroid disorders are amongst the most prevalent of medical conditions possibly after diabetes. The prevalence of thyroid dysfunction in adults in the general population ranges from 1 to 10 percent, and is even higher in selected groups. In the United Kingdom, 1–2% of the adult population is found to have thyroid dysfunction. It is interesting to note that thyroxin is the sixth most commonly dispensed drug in Scotland. Virtually all studies report higher prevalence rates for hypothyroidism in women and with advancing age. Abnormal thyroid functions have important public health consequences. Suppressed TSH levels have been associated with decreased bone density and with an increased risk of atrial fibrillation and premature atrial beat. It has been known for decades that overt hypothyroidism contributes to elevated serum cholesterol levels and cardiovascular risk and recent studies suggest this may also be true with subclinical hypothyroidism.
This integrated clinical reference offers candid coverage and informed views on thyroid function and disease. Carefully detailed line drawings elucidate the discussions by 3 renowned clinicians. Coverage includes thyroid hormone biosynthesis, laboratory evaluation, nontoxic goiter, hyperthyroidism, thyroid disease in pregnancy, malignant diseases, thyroiditis, and much more.
"This book will bridge a gap between the huge platform of literature available on the subject of thyroid surgery and the pratical working reality. The pearls in techniques and surgical procedures will be exhaustively detailed with authors' individual experience enriched with quality photographs"--
An outstanding reference for performing successful thyroid operations Atlas of Thyroid Surgery: Principles, Practice, and Clinical Cases is a concise guide for the surgical management of thyroid disease. Divided in three main parts, the book opens with an overview of surgical anatomy and surgical techniques. The author provides a detailed description of the technique of capsular dissection as well as surgical cases that aid in the comprehension of important concepts. The book then features an in-depth discussion of thyroid nodules, including follicular neoplasms and nodules in Graves and Hashimoto disease, covering basic science, genetics, clinical aspects, imaging, diagnosis, and surgical strategies. In the final part, the atlas addresses the management of malignant tumors, including papillary, anaplastic, and medullary carcinoma, and describes the principles of classification, treatment strategies along with current therapeutic controversies, and results. For differentiated thyroid carcinoma, contemporary strategies focus on selective risk-dependent treatment that allows for the protection of patients from overtreatment.Highlights: Descriptions of endocrine pathophysiology and the pathogenesis of nodular goiter and thyroid neoplasms Thorough discussion of the capsular dissection technique and its essential advantages as a minimally invasive approach with low morbidity Numerous clinical cases with step-by-step demonstrations of surgical procedures and concise comments on management, helping clinicians prepare for range of scenarios encountered in everyday practice 120 clear line drawings and full-color photographs that illustrate key concepts Surgical videos on accompanying Thieme MediaCenter web page present detailed surgical technique in five clinical cases with cross references to the text Atlas of Thyroid Surgery: Principles, Practice, and Clinical Cases is a superb guide for general surgeons and endocrine and ENT surgeons operating on the thyroid. Endocrinologists, oncologists, pathologists, and residents in these specialties will also greatly benefit from the wealth of information provided in the text.
If you are one of the more than 14 million Americans who suffers from a thyroid disorder, knowingly or unknowingly, Thyroid Balance is the key to restoring your health and well-being. Never before has there been a comprehensive guide that explains all the traditional and alternative methods available for treating thyroid disorders, and allows you to become an active participant in designing a balanced, practical treatment program. Using the amassed knowledge of twenty-five years at the forefront of the complementary medicine movement, Dr. Glenn S. Rothfeld answers every question the thyroid patient might have, including how to: recognize a thyroid condition determine if the adrenal gland is the real culprit distinguish between hypo, hyper, autoimmune, and subclinical conditions integrate conventional and alternative treatments know what to do when treatment fails get your metabolism and your body thermostat back under control control weight gain and loss and so much more!
The discovery of the negative feedback of thyroid hormones on pituitary thyroid-stimulating hormone (TSH) secretion, a classical endocrine feedback control system, has shaped diagnosis and treatment of thyroid disease for the last decades. Based on this concept, a unique diagnostic category of subclinical thyroid disorders was introduced, being defined exclusively by an abnormal TSH response in the presence of thyroid hormone concentrations within the reference range. Although this approach was able to deliver a conceptually straightforward disease definition problems surfaced in clinical practice as neither the diagnostic reference range nor the appropriate threshold for initiating substitution treatment are universally agreed upon for subclinical thyroid disorders. The situation is further aggravated by the so-called syndrome T, which comprises a substantial but heterogeneous group of L-T4 treated patients with hypothyroidism with reduced quality of life despite “normal” TSH values. A limited understanding of the physiological relationships between TSH and thyroid hormones may be a main reason for clinical difficulties in dealing with the causes of syndrome T and tailoring substitution therapy for hypothyroid patients with subclinical thyroid disorders. Feedback regulation has recently been shown to be much more complex than previously assumed. The concept of homeostatic control has also been extended to include the lesser known but equally important allostatic thyroid regulation.The latter aims at adaptive homeostasis or stability through changing setpoints and modulating structural parameters of feedback control, as may be appropriate to adapt to a vast array of conditions spanning from fetal life, aging, pregnancy, exercise, starvation, obesity, psychiatric disorders to the severe non-thyroidal illness syndrome. A better understanding of homeostatic and allostatic mechanisms, which govern the behaviour of pituitary-thyroid feedback control, is on the horizon. This promises to improve the diagnostic utility of laboratory methods, laying the foundation for personalised methods to optimise dosage and modality of substitution therapy. The emerging new world of thyroid physiology is reflected on the side of clinical medicine in a new, relational paradigm for diagnosis and treatment. Considerable progress has been made in this respect in the following key areas: • the significance of complementary information processing structures within the feedback loop, in particular ultrashort feedback of TSH on its own secretion and the action of a TSH-T3 shunt unburdening the thyroid from T4 synthesis in imminent thyroid failure, • the unravelling of spatio-temporal dynamics of hormone concentrations ranging from ultradian to circannual rhythms and including hysteresis effects, • the emergence of “non-canonical” mechanisms of thyroid hormone signalling beyond transcriptional control of gene expression, • the physiological actions of thyronine metabolites, which have been previously regarded as biologically inactive, such as thyronamines and iodothyroacetates, • the characterisation of distinct patterns in the adaptive processes to stress and strain and their conclusive explanation through reactions to type 1 and type 2 allostatic load. This collective volume contains the contributions to the Research Topic “Homeostasis and Allostasis of Thyroid Function”, which was originally published by the journal Frontiers in Endocrinology. Authored by an international team of experts from three continents ,the book provides a comprehensive overview on thyroid control from recent research in basic, computational and clinical thyroidology. Many aspects addressed here can be expected to stimulate future research. A more comprehensive view and better integration of in-vitro, in-silico and in-vivo investigations will be invaluable in paving the way to this new world of thyroidology.