[PDF] Polylactic Co Glycolic Acid Plga Nanoparticles For Drug Delivery eBook

Author : Prashant Kesharwani
Publisher : Elsevier
Page : 534 pages
File Size : 25,38 MB
Release : 2023-03-02
Category : Technology & Engineering
ISBN : 0323914314

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Poly(lactic-co-glycolic acid) (PLGA) Nanoparticles for Drug Delivery is a comprehensive guide to PLGA nanoparticles for targeting various diseases, covering principles, formation, characterization, applications, regulations and the latest advances. Sections introduce the fundamental aspects of PLGA nanoparticles for drug delivery, including properties, preparation methods, characterization, drug loading methods, and drug release mechanisms, along with a focus on applications. Application of PLGA nanoparticles for the treatment of cancer, inflammatory, cerebral, cardiovascular, and infectious diseases, as well as in regenerative medicine, photodynamic and photothermal therapy, and gene therapy, are all explained in detail. The final chapters explore recent advances and regulatory aspects. This book is a valuable resource for researchers and advanced students across nanomedicine, polymer science, bio-based materials, chemistry, biomedicine, biotechnology, and materials engineering, as well as for industrial scientists and R&D professionals with an interest in nanoparticles for drug delivery, pharmaceutical formulations and regulations, and development of innovative biodegradable materials. Presents the fundamentals of PLGA nanoparticles, including properties, preparation, characterization, and biofate and cellular interactions Provides in-depth coverage of a broad range of specific applications of PLGA nanoparticles across disease treatment, regenerative medicine and therapeutic areas Offers a methodical approach to PLGA nanoparticles in drug delivery that is supported by data tables, illustrative figures and flowcharts

Author : Maria Carmo Pereira
Publisher : MDPI
Page : 328 pages
File Size : 22,3 MB
Release : 2021-03-01
Category : Science
ISBN : 3036502203

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Poly(lactic-co-glycolic acid) (PLGA) is one of the most successful polymers used for producing therapeutic devices, such as drug carriers (DC). PLGA is one of the few polymers that the Food and Drug Administration (FDA) has approved for human administration due to its biocompatibility and biodegradability. In recent years, DC produced with PLGA has gained enormous attention for its versatility in transporting different type of drugs, e.g., hydrophilic or hydrophobic small molecules, or macromolecules with a controlled drug release without modifying the physiochemical properties of the drugs. These drug delivery systems have the possibility/potential to modify their surface properties with functional groups, peptides, or other coatings to improve the interactions with biological materials. Furthermore, they present the possibility to be conjugated with specific target molecules to reach specific tissues or cells. They are also used for different therapeutic applications, such as in vaccinations, cancer treatment, neurological disorder treatment, and as anti-inflammatory agents. This book aims to focus on the recent progress of PLGA as a drug carrier and their new pharmaceutical applications.

Author : Yi Peng
Publisher : Springer Science & Business Media
Page : 787 pages
File Size : 11,89 MB
Release : 2008-05-17
Category : Technology & Engineering
ISBN : 354079039X

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This volume presents the proceedings of the 7th Asian-Pacific Conference on Medical and Biological Engineering (APCMBE 2008). Themed "Biomedical Engineering – Promoting Sustainable Development of Modern Medicine" the proceedings address a broad spectrum of topics from Bioengineering and Biomedicine, like Biomaterials, Artificial Organs, Tissue Engineering, Nanobiotechnology and Nanomedicine, Biomedical Imaging, Bio MEMS, Biosignal Processing, Digital Medicine, BME Education. It helps medical and biological engineering professionals to interact and exchange their ideas and experiences.

Author : Katherine Mackenzie North
Publisher :
Page : 58 pages
File Size : 38,32 MB
Release : 2021
Category :
ISBN :

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Traumatic brain injury (TBI) presents a serious challenge for modern medicine due to the poor regenerative capabilities of the brain, complex pathophysiology, and lack of effective treatment for TBI to date. The overall goal of this research is to develop as nanoparticle capable of sustained drug release for the delivery and treatment of TBI so that therapeutic drug can be delivered after the Blood Brain Barrier (BBB) closes 24 hours after injury. Poly(lactic-co-glycolic acid) (PLGA) nanoparticles have shown some experimental success; as of yet, none have yielded improved results of clinical efficacy. Polyethylene Glycol (PEG) has been shown to act as a stealth molecule that can increase the circulation time of particles. N-acetylcysteine has shown neuroprotective and anti-inflammatory potential. This paper presents the development of PEGylated PLGA NPs synthesized using double and single emulsion for potential therapeutic delivery to TBI. Dynamic light scattering (DLS) show PEG-PLGA NPs to have an average diameter of 200 nm. Loading capacity was obtained at 2%, and drug encapsulation efficiency was obtained at 55%. A biphasic drug release pattern was noted in situ and drug release was assessed in vitro over 72 h using FRET nanoparticles, almost complete release of drug was seen during this time period. Finally, in vivo administration of PEG-PLGA NPs demonstrated that PEGylated NPS were able to show reduced accumulation in filtration organs such as the liver and kidneys compared to bare PLGA particles. This evidence supports the potential of PEG-PLGA NPs as a promising carrier to develop TBI therapeutics.

Author : Nico Bruns
Publisher : Royal Society of Chemistry
Page : 613 pages
File Size : 12,55 MB
Release : 2016-10-14
Category : Science
ISBN : 1782626662

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Many key aspects of life are based on naturally occurring polymers, such as polysaccharides, proteins and DNA. Unsurprisingly, their molecular functionalities, macromolecular structures and material properties are providing inspiration for designing new polymeric materials with specific functions, for example, responsive, adaptive and self-healing materials. Bio-inspired Polymers covers all aspects of the subject, ranging from the synthesis of novel polymers, to structure-property relationships, materials with advanced properties and applications of bio-inspired polymers in such diverse fields as drug delivery, tissue engineering, optical materials and lightweight structural materials. Written and edited by leading experts on the topic, the book provides a comprehensive review and essential graduate level text on bio-inspired polymers for biochemists, materials scientists and chemists working in both industry and academia.

Author : Jeffrey O. Hollinger
Publisher : CRC Press
Page : 500 pages
File Size : 40,82 MB
Release : 2004-10-14
Category : Medical
ISBN : 1135501912

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Focusing on bone biology, Bone Tissue Engineering integrates basic sciences with tissue engineering. It includes contributions from world-renowned researchers and clinicians who discuss key topics such as different models and approaches to bone tissue engineering, as well as exciting clinical applications for patients. Divided into four sections, t

Author : Geetha Venkatachalam
Publisher : Springer Science & Business Media
Page : 99 pages
File Size : 43,62 MB
Release : 2012-10-05
Category : Science
ISBN : 3642329950

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to Cyclic glucans are polysaccharides that are predominantly produced by Agrobacterium, Bradyrhizobium and Rhizobium sp. and widely used in the pharmaceutical and food industries. In this book, the applications, properties, analytical tools, production and genes of four main cyclic β-glucans from microorganisms are highlighted and critically evaluated. As biocompatible and biodegradable renewable resources, they have an immense potential for future applications, which has not yet been fully exploited. This concise review will help to bridge this gap.

Author : Maria Carmo Pereira
Publisher :
Page : 328 pages
File Size : 38,54 MB
Release : 2021
Category :
ISBN : 9783036502212

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Poly(lactic-co-glycolic acid) (PLGA) is one of the most successful polymers used for producing therapeutic devices, such as drug carriers (DC). PLGA is one of the few polymers that the Food and Drug Administration (FDA) has approved for human administration due to its biocompatibility and biodegradability. In recent years, DC produced with PLGA has gained enormous attention for its versatility in transporting different type of drugs, e.g., hydrophilic or hydrophobic small molecules, or macromolecules with a controlled drug release without modifying the physiochemical properties of the drugs. These drug delivery systems have the possibility/potential to modify their surface properties with functional groups, peptides, or other coatings to improve the interactions with biological materials. Furthermore, they present the possibility to be conjugated with specific target molecules to reach specific tissues or cells. They are also used for different therapeutic applications, such as in vaccinations, cancer treatment, neurological disorder treatment, and as anti-inflammatory agents. This book aims to focus on the recent progress of PLGA as a drug carrier and their new pharmaceutical applications.