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Lectures on the isobar-hole model for pion reactions include the isobar as an explicit degree of freedom and the connection with a purely pion and nucleon system, the formalism and its relation to the pion optical potential, the extended schematic model for pion scattering, a simple spinless s-wave model, application to pion-oxygen 16 scattering and comparison with elastic scattering data. In this way the extent is shown to which microscopic treatment of the many-body dynamics explains the data and the extent to which additional physical input is required. Another test is the various inelastic processes. Inclusive reactions are briefly discussed. 37 references (JFP).