[PDF] Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 479 Genetic Toxicology In Vitro Sister Chromatid Exchange Assay In Mammalian Cells eBook

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OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 479: Genetic Toxicology: In vitro Sister Chromatid Exchange Assay in Mammalian Cells

OECD
OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 479: Genetic Toxicology: In vitro Sister Chromatid Exchange Assay in Mammalian Cells by OECD PDF

Author : OECD
Publisher : OECD Publishing
Page : 5 pages
File Size : 42,65 MB
Release : 1986-10-23
Category :
ISBN : 9264071385

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The sister chromatid exchange (SCE) assay is a short-term test for the detection of reciprocal exchanges of DNA between two sister chromatids of a duplicating chromosome. Detection of SCEs requires some means of differentially labeling sister ...

OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 482: Genetic Toxicology: DNA Damage and Repair, Unscheduled DNA Synthesis in Mammalian Cells in vitro

OECD
OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 482: Genetic Toxicology: DNA Damage and Repair, Unscheduled DNA Synthesis in Mammalian Cells in vitro by OECD PDF

Author : OECD
Publisher : OECD Publishing
Page : 7 pages
File Size : 50,19 MB
Release : 1986-10-23
Category :
ISBN : 926407144X

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The Test Guideline for Unscheduled DNA Synthesis (UDS) in mammalian cells in vitro describes procedures utilizing primary cultures, human lymphocytes or established cell lines, to detect DNA repair synthesis after excision and removal of a stretch ...

OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 485: Genetic toxicology, Mouse Heritable Translocation Assay

OECD
OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 485: Genetic toxicology, Mouse Heritable Translocation Assay by OECD PDF

Author : OECD
Publisher : OECD Publishing
Page : 6 pages
File Size : 20,71 MB
Release : 1986-10-23
Category :
ISBN : 9264071504

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The mouse heritable translocation test detects structural and numerical chromosome changes in mammalian germ cells as recovered in first generation progeny. The types of chromosome changes detected in this test system are reciprocal translocations ...

OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 481: Genetic Toxicology: Saacharomyces cerevisiae, Miotic Recombination Assay

OECD
OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 481: Genetic Toxicology: Saacharomyces cerevisiae, Miotic Recombination Assay by OECD PDF

Author : OECD
Publisher : OECD Publishing
Page : 6 pages
File Size : 36,1 MB
Release : 1986-10-23
Category :
ISBN : 9264071423

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This assay may be used to measure mitotic recombination (gene conversion or crossingover) in yeast, a eukaryotic micro-organism. Crossing-over is generally assayed by the production of recessive homozygous colonies or sectors produced in a ...

OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 470: Mammalian Erythrocyte Pig-a Gene Mutation Assay

OECD
OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 470: Mammalian Erythrocyte Pig-a Gene Mutation Assay by OECD PDF

Author : OECD
Publisher : OECD Publishing
Page : 37 pages
File Size : 16,48 MB
Release : 2022-06-30
Category :
ISBN : 9264366067

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This Test Guideline describes an in vivo erythrocyte Pig-a gene mutation assay (hereafter called the Pig-a assay) which uses an endogenous mammalian gene, the phosphatidylinositol glycan class A gene (Pig-a), as a reporter of somatic-cell gene mutation. In vivo gene mutation tests, such as the Pig-a assay, are especially relevant for assessing mutagenicity because physiological factors, such as absorption of the test chemical from the site of exposure, distribution of the test chemical throughout the test system via systemic circulation, and in vivo metabolism and DNA repair processes, all contribute to the mutagenic responses.

OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 480: Genetic Toxicology: Saccharomyces cerevisiae, Gene Mutation Assay

OECD
OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 480: Genetic Toxicology: Saccharomyces cerevisiae, Gene Mutation Assay by OECD PDF

Author : OECD
Publisher : OECD Publishing
Page : 5 pages
File Size : 12,12 MB
Release : 1986-10-23
Category :
ISBN : 9264071407

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This assay may be used to measure gene mutation in yeast, a eukaryotic micro-organism. Strains of Saccharomyces cerevisiae have been developed which detect forward or reverse mutations. A variety of haploid and diploid strains of the yeast can be ...