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OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 480: Genetic Toxicology: Saccharomyces cerevisiae, Gene Mutation Assay

OECD
OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 480: Genetic Toxicology: Saccharomyces cerevisiae, Gene Mutation Assay by OECD PDF

Author : OECD
Publisher : OECD Publishing
Page : 5 pages
File Size : 33,77 MB
Release : 1986-10-23
Category :
ISBN : 9264071407

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This assay may be used to measure gene mutation in yeast, a eukaryotic micro-organism. Strains of Saccharomyces cerevisiae have been developed which detect forward or reverse mutations. A variety of haploid and diploid strains of the yeast can be ...

OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 476: In Vitro Mammalian Cell Gene Mutation Tests using the Hprt and xprt genes

OECD
OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 476: In Vitro Mammalian Cell Gene Mutation Tests using the Hprt and xprt genes by OECD PDF

Author : OECD
Publisher : OECD Publishing
Page : 18 pages
File Size : 31,95 MB
Release : 2016-07-29
Category :
ISBN : 9264264809

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The in vitro mammalian cell gene mutation test can be used to detect gene mutations induced by chemical substances. In this test, the used genetic endpoints measure mutation at hypoxanthine-guanine phosphoribosyl transferase (HPRT), and at a transgene of xanthineguanine phosphoribosyl transferase...

Test No. 488: Transgenic Rodent Somatic and Germ Cell Gene Mutation Assays

OECD
Test No. 488: Transgenic Rodent Somatic and Germ Cell Gene Mutation Assays by OECD PDF

Author : OECD
Publisher : OECD Publishing
Page : 16 pages
File Size : 24,32 MB
Release : 2011-07-28
Category :
ISBN : 9264122818

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This Test Guideline describes an in vivo assay that detects chemicals that may induce gene mutations. In this assay, transgenic rats or mice that contain multiple copies of chromosomally integrated plasmid or phage shuttle vectors are used. The ...

OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 414: Prenatal Developmental Toxicity Study

OECD
OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 414: Prenatal Developmental Toxicity Study by OECD PDF

Author : OECD
Publisher : OECD Publishing
Page : 14 pages
File Size : 43,88 MB
Release : 2018-06-27
Category :
ISBN : 9264070826

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This Test Guideline for developmental toxicity testing is designed to provide general information concerning the effects of prenatal exposure on the pregnant test animal and on the developing organism. The test substance is normally administered to ...

OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 470: Mammalian Erythrocyte Pig-a Gene Mutation Assay

OECD
OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 470: Mammalian Erythrocyte Pig-a Gene Mutation Assay by OECD PDF

Author : OECD
Publisher : OECD Publishing
Page : 37 pages
File Size : 50,42 MB
Release : 2022-06-30
Category :
ISBN : 9264366067

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This Test Guideline describes an in vivo erythrocyte Pig-a gene mutation assay (hereafter called the Pig-a assay) which uses an endogenous mammalian gene, the phosphatidylinositol glycan class A gene (Pig-a), as a reporter of somatic-cell gene mutation. In vivo gene mutation tests, such as the Pig-a assay, are especially relevant for assessing mutagenicity because physiological factors, such as absorption of the test chemical from the site of exposure, distribution of the test chemical throughout the test system via systemic circulation, and in vivo metabolism and DNA repair processes, all contribute to the mutagenic responses.

OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 490: In Vitro Mammalian Cell Gene Mutation Tests Using the Thymidine Kinase Gene

OECD
OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 490: In Vitro Mammalian Cell Gene Mutation Tests Using the Thymidine Kinase Gene by OECD PDF

Author : OECD
Publisher : OECD Publishing
Page : 24 pages
File Size : 46,24 MB
Release : 2016-07-29
Category :
ISBN : 9264264906

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This TG includes two distinct in vitro mammalian gene mutation assays requiring two specific tk heterozygous cells lines: L5178Y tk+/-3.7.2C cells for the mouse lymphoma assay (MLA) and TK6 tk+/- cells for the TK6 assay.

OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 432: In Vitro 3T3 NRU Phototoxicity Test

OECD
OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 432: In Vitro 3T3 NRU Phototoxicity Test by OECD PDF

Author : OECD
Publisher : OECD Publishing
Page : 20 pages
File Size : 24,65 MB
Release : 2004-11-23
Category :
ISBN : 9264071164

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This Test Guideline describes a method to evaluate photo-cytotoxicity by the relative reduction in viability of cells exposed to the chemical in the presence versus absence of light. Balb/c 3T3 cells are maintained in culture for 24 h for formation ...