[PDF] Non Invasive Neuromodulation Of The Central Nervous System eBook

Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
Page : 103 pages
File Size : 49,59 MB
Release : 2015-11-02
Category : Medical
ISBN : 0309376211

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Based on advances in biotechnology and neuroscience, non-invasive neuromodulation devices are poised to gain clinical importance in the coming years and to be of increasing interest to patients, clinicians,health systems, payers, and industry. Evidence suggests that both therapeutic and non-therapeutic applications of non-invasive neuromodulation will continue to expand in coming years, particularly for indications where treatments are currently insufficient, such as drug-resistant depression. Given the growing interest in non-invasive neuromodulation technologies, the Institute of Medicine's Forum on Neuroscience and Nervous System Disorders convened a workshop, inviting a range of stakeholders - including developers of devices and new technologies, researchers, clinicians, ethicists, regulators, and payers - to explore the opportunities, challenges, and ethical questions surrounding the development, regulation, and reimbursement of these devices for the treatment of nervous system disorders as well as for non-therapeutic uses, including cognitive and functional enhancement. This report highlights the presentation and discussion of the workshop.

Author : Matteo Bologna
Publisher : Frontiers Media SA
Page : 149 pages
File Size : 17,1 MB
Release : 2020-02-13
Category :
ISBN : 2889634698

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The possibility of harvesting the power of electric and magnetic impulses in the human body, commonly referred to as “neuromodulation,” is one of the most recent and promising developments of the modern science. Since the late ´60s, multiple invasive and non-invasive technologies have been developed and tested in experimental and clinical settings with the final aim of modulating the function of the central and peripheral nervous system. Clinical applications include, but are not limited to, common neurological disorders such as Parkinson’s disease and other movement disorders. The bulk of evidence supporting the clinical efficacy of various invasive and non-invasive approaches for neuromodulation has progressively led scientific societies, patients’ associations, and regulatory entities to acknowledge the critical role played by neuromodulation in the therapeutic algorithms of a wide range of neurological disorders. As a result, new technologies have been recently introduced into the market or are currently under validation. Their potential implementation into innovative protocols for neuromodulation demands a critical revision of what are the unmet needs for neuromodulation in movement disorders.

Author : Yushan Wang
Publisher :
Page : 198 pages
File Size : 15,34 MB
Release : 2022
Category :
ISBN :

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Neuromodulation, targeting either the central nervous system or peripheral nervous system, is a viable therapy for many diseases, particularly for patients who are refractory to traditional treatments. The first part of this thesis aims to develop the non-invasive neuromodulation technique targeting the central nervous system, specifically the brain with transcranial direct current stimulation (tDCS). Compared to the conventional tDCS which uses two large pad electrodes, high-density tDCS has recently received more attention. With the high-density electrode system, it is able to achieve better stimulation performance in terms of stimulation intensity and focality. To further improve the performance of this promising technique, we characterize the performance with respect to the electrode factor for the high-density tDCS system. In addition, we have developed an optimization algorithm, Stimulation with Balanced Focality and Intensity (SBFI), to guide the high-density system, which provides effective and focal stimulation. The robustness of the computational model with standard tissue conductivity is also evaluated. The proposed technique can be applied to transcutaneous spinal cord stimulation (tSCS). The second part aims to develop the electrical modulation technique targeting the peripheral nervous system, specifically one of the second brain organs - colon. Electrical stimulation has been demonstrated as an alternative approach to alleviate intractable colonic motor disorders. However, knowledge of optimal electrical stimulation modalities and regional specific functional effects of colonic neuromodulation is lacking. We have investigated the regional colonic motility in response to different electrical stimulation modalities. In addition, we have developed a novel and efficient technique employing bio-impedance characterization to monitor colonic motor activity.

Author : Clement Hamani
Publisher : John Wiley & Sons
Page : 518 pages
File Size : 49,44 MB
Release : 2016-01-26
Category : Medical
ISBN : 1118801040

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Edited by an expert multidisciplinary team, Neuromodulation in Psychiatry is the first reference guide to address both invasive and non-invasive neuromodulation strategies used in psychiatry. Covers basic principles, technical aspects, clinical applications and ethical considerations Presents up-to-date evidence in comprehensive summaries suitable for all levels of experience Each technique is clearly explained along with its implications for real-world clinical practice Allows psychiatrists to make informed decisions regarding neuromodulation for their patients

Author : Firas H. Kobeissy
Publisher : CRC Press
Page : 718 pages
File Size : 31,40 MB
Release : 2015-02-25
Category : Medical
ISBN : 1466565993

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With the contribution from more than one hundred CNS neurotrauma experts, this book provides a comprehensive and up-to-date account on the latest developments in the area of neurotrauma including biomarker studies, experimental models, diagnostic methods, and neurotherapeutic intervention strategies in brain injury research. It discusses neurotrauma mechanisms, biomarker discovery, and neurocognitive and neurobehavioral deficits. Also included are medical interventions and recent neurotherapeutics used in the area of brain injury that have been translated to the area of rehabilitation research. In addition, a section is devoted to models of milder CNS injury, including sports injuries.

Author : Sergey N. Makarov
Publisher : Springer Nature
Page : 395 pages
File Size : 30,93 MB
Release : 2021
Category : Biomedical engineering
ISBN : 3030456234

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The 41st Annual International Conference of the IEEE EMBS, took place between July 23 and 27, 2019, in Berlin, Germany. The focus was on "Biomedical engineering ranging from wellness to intensive care." This conference provided an opportunity for researchers from academia and industry to discuss a variety of topics relevant to EMBS and hosted the 4th Annual Invited Session on Computational Human Models. At this session, a bevy of research related to the development of human phantoms was presented, together with a substantial variety of practical applications explored through simulation.

Author :
Publisher : Academic Press
Page : 1089 pages
File Size : 16,19 MB
Release : 2009-05-05
Category : Science
ISBN : 0080921396

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Neuromodulation will be the first comprehensive and in-depth reference textbook covering all aspects of the rapidly growing field of neuromodulation. This book provides a complete discussion of the fundamental principles of neuromodulation and therapies applied to the brain, spinal cord, peripheral nerves, autonomic nerves and various organs. The textbook is highly structured and organized into overarching sections that cover chronic pain, movement disorders, psychiatric disorders, epilepsy, functional electrical stimulation, cardiac, gastrointestinal, genitourinary and organ neuromodulation. The fundamental principles of electricity and infusion, neural tissue interface, biomedical engineering, neuromodulation devices, basic science, neuroanatomy, neurophysiology, imaging and mechanisms are emphasized. In addition to providing details pertaining to the state-of-the-art current practice, innovative and emerging applications are discussed in specific chapters. Finally, the textbook provides specific chapters focusing on the technical aspects of the various neuromodulation procedures as well as technical specifications of various implantable devices. All of the contributors to Neuromodulation represent leading experts in the field. The editors are internationally renowned in their respective fields of neuromodulation, pain management, functional neurosurgery and biomedical engineering. Neuromodulation will be the first and foremost authoritative text on neuromodulation therapies and will establish the gold standard that defines the field for years to come. Key Features The first comprehensive reference on the emerging field of Neuromodulation Editors and authors include all leading figures in the field, and the leaders of the International Neuromodulation Society Over 90 chapters on topics ranging from a layout of the fundamentals (e.g. neuroanatomy, plasticity, bioelectrical effects, infusion therapies), solutions for the biomedical engineering challenges (e.g. materials, how to preserve normal function etc.), to a rundown of the existing applications and their future promise Over 1200 pages in splendid full color, richly illustrated Important areas of application include: control of chronic pain delivery of drugs to the nervous system via implanted devices control of epilepsy, Parkinson, etc. functional restoration, e.g. visual, auditory, restoration after stroke, restoration of motor function after traumatic events stimulation of body organs via neural devices (incl. the heart, abdominal organs, genitourinary organs) overview over newly emerging fields - control of obesity, blood pressure, tinnitus, brain injury, neurodegenerative diseases, brain-machine interfaces

Author : K.V. Slavin
Publisher : Karger Medical and Scientific Publishers
Page : 258 pages
File Size : 43,17 MB
Release : 2015-09-09
Category : Medical
ISBN : 3318028096

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Among neuromodulation procedures, electrical stimulation of peripheral nerves (PNS) is probably the most underappreciated modality. Although PNS is used for all kinds of medical conditions, ranging from chronic neuropathic pain and headache to epilepsy, depression, hypertension and heart failure, its importance is frequently overshadowed by spinal cord stimulation and deep brain stimulation. While the earlier version of this book dealt exclusively with various pain syndromes, this new volume covers the entire spectrum of PNS applications. Written by recognized authorities in their respective fields, the chapters of this title describe the use of PNS in the management of neurological, psychiatric, otorhinolaryngological, cardiovascular, pulmonary, colorectal and genitourinary disorders. To reflect the complexity of the regulatory process, the book ends with a special chapter dedicated to the current state of approval of different PNS devices. This book will be of great value to all those who deal with neuromodulation, including clinicians who select PNS candidates, surgeons and other specialists who implant PNS devices, and researchers and engineers who work on making the stimulators safer and more effective.