[PDF] Next Generation Antimicrobial Nanocoatings For Medical Devices And Implants eBook

Author : Pratima R. Solanki
Publisher : Elsevier
Page : 317 pages
File Size : 14,45 MB
Release : 2024-01-12
Category : Technology & Engineering
ISBN : 0323957579

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Next-Generation Antimicrobial Nanocoatings for Medical Devices and Implants provides a detailed, up-to-date overview of nano-based antimicrobial coatings used to combat medical device-related biofilms. An introduction to biofilms and how they infect medical devices is included, as well as strategies/modification techniques used to target these biofilms. This book evaluates the various antimicrobial coatings formed using nanomaterials such as silver, inorganic materials, organic materials, carbon dots, surfactants, and electrospun fibers, specifically for us on medical devices and implants. Numerous coating methods are discussed along with the biological characterizations of these coating materials, and their toxicological and environmental impact.Next-generation Antimicrobial Nanocoatings for Medical Devices and Implants is a useful reference for materials scientists, biomedical engineers, and those working on the development of novel biomaterials for use in medical devices and implants. Provides a range of nanomaterials for use in antimicrobial coatings, including electrospun fibers, surfactants, carbon quantum dots, and more Details various modification approaches for targeting biofilms, as well as nanocoating characterization and methods for use on medical devices and implants Assesses the environmental and toxicological impact of antimicrobial nanocoatings

Author : Zheng Zhang
Publisher : Springer
Page : 277 pages
File Size : 44,78 MB
Release : 2017-05-24
Category : Technology & Engineering
ISBN : 3319574949

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Based on a fundamental understanding of the interaction between bacteria and materials, this timely volume emphasizes the latest research in the antimicrobial interfacial design and provides an invaluable blueprint for improving antimicrobial performance on devices and products. Antimicrobial Coatings and Modifications targets reduction of microbial accumulation on biomedical and industrial materials through changing interfacial characteristics. Applying a viable antimicrobial coating or modification to resist alarming threats is a highly demanding requirement for many medical and engineering applications. Many contemporary books in the area of antimicrobial solution focus on applying antimicrobial agents or materials that can kill bacteria. The volume pays more attention to eliminating bacterial contamination and biofilm formation through surface characteristics with minimized bacterial resistance and environmental impact.

Author : Vivek Mishra
Publisher : CRC Press
Page : 304 pages
File Size : 49,23 MB
Release : 2024-08-01
Category : Technology & Engineering
ISBN : 1040101461

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Nanotherapeutics for Inflammatory Arthritis: Design, Diagnosis, and Treatment highlights nanobiotechnology and its therapeutic applications in the field of inflammatory arthritis, the interaction of nanomaterials in the biological systems, and clinical development of nanomedicines. It also covers the discovery of personalized therapeutics, diagnostics, and nanoparticular delivery systems, the role of bioinformatics nanobiotechnology in personalized oncology. The use of nanosensors for the detection and current challenges in the development of personalized medicine is explained including recent nanotechnology-based strategies. Features: Covers all the fundamental information about nanotechnology and inflammatory arthritis. Highlights the interaction of nanomaterials in the biological systems, and the clinical development of nanomedicines for inflammatory arthritis. Explores the discovery of personalized therapeutics, diagnostics, and nanoparticle delivery systems. Reviews the current challenges in the development of personalized medicine as well as translation of nanomedicine with combination therapy. Discusses the toxicology of using nanomedicines and the risks associated with the use of these nanomedicines. This book is aimed at researchers and professionals in nanotechnology, biomaterial, drug delivery, and inflammatory arthritis.

Author : Huiliang Cao
Publisher : CRC Press
Page : 634 pages
File Size : 36,34 MB
Release : 2017-05-18
Category : Medical
ISBN : 1315353474

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Since the potential toxicity of silver nanoparticles (Ag NPs) has raised serious concerns in the biomaterials and biomedical engineering community, Silver Nanoparticles for Antibacterial Devices: Biocompatibility and Toxicity brings together the synthesis, the physicochemical properties and the biological actions of Ag NPs, as well as the clinical demands for fabricating antibacterial medical devices, discussing how to suppress the side effects of nanomaterials and how to impart to them the selective toxicity. This book presents the two primary paradigms that have emerged in probing the antibacterial applications of Ag NPs, i.e. the active attacking releasing way and the conservative defending approach by taking advantage of various short-range actions; it shows readers how the ways in which Ag NPs have behaved can be engineered purposively. With contributions from leading international experts and extensive references listed in each chapter, this volume provides the general principles on controlling the physicochemical behaviors of nanomaterials and managing their toxicity risks.

Author : Garg, Rajni
Publisher : IGI Global
Page : 461 pages
File Size : 32,90 MB
Release : 2024-02-27
Category : Technology & Engineering
ISBN :

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It is essential to harness the potential of nanotechnology in a rapidly evolving industrial environment. As industries grapple with the demand for more advanced, efficient, and sustainable solutions, the intricate amalgamation of chemistry, materials science, physics, biology, and technology in nanotechnology emerges as both a beacon of promise and a complex puzzle. The groundbreaking book, Sustainable Approach to Protective Nanocoatings, serves as a transformative solution. Tailored for academic scholars seeking comprehensive insights, this book navigates the labyrinth of nanotechnology with precision, offering a roadmap for leveraging nanostructured materials and coatings to meet the demands of the modern industrial world. By seamlessly weaving together the intricate tapestry of research methodologies, applications, and technological advances, the book emerges as an indispensable resource for those poised at the intersection of academia and industry.

Author : Urban Ajdnik
Publisher :
Page : 156 pages
File Size : 18,43 MB
Release : 2021
Category :
ISBN :

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The aim of this Doctoral Dissertation was to develop an anti-biofilm multifunctional coating of the next generation for medical devices, and to gain understanding of the solid/liquid interactions between the components of the polyelectrolyte-surfactant complex (chitosan, lysine-based surfactant) as a colloidal formulation (coating) and solid surface of PDMS, with subsequent study of the detailed surface characteristics of this kind of functionalised materials and further examination of the bioactive properties of the coatings: i) Protein interactions, ii) Microbiology testing and iii) Biocompatibility assays. The interactions between positively charged biopolymer chitosan and an anionic surfactant derived from lysine (77KS) were studied with turbidity and surface tension measurements, %-potential and Dynamic Light Scattering. Chitosan and 77KS form complexes which reverse their charge at higher 77KS concentration, forming larger aggregates that were loaded with drugs (amoxicillin, AMOX). A QCM-D study showed irreversible adsorption of the coatings on a model silicone (polydimethylsiloxane; PDMS) surface, even after the rinsing step, while their presence and homogeneity were confirmed via surface analyses using XPS and ToF-SIMS. The effect was also examined of the ionic strength and of the ultraviolet/ozone (UVO) activation of the PDMS films on the adsorption behaviour of the formulations. An important part of this study was devoted to understanding the underlying adsorption phenomena and identifying the mechanisms associated with biofouling. The adsorption of a number of proteins was investigated, together with their mixture on PDMS surfaces. Different proteins with different physicochemical properties were tested (bovine serum albumin, fibrinogen, gamma globulin and their mixture). Adsorption experiments were performed with a quartz crystal microbalance. The adsorption properties of the test proteins were investigated. Moreover, adsorption of proteins was also followed through %-potential measurements, with comparison of the results of both techniques. IX The additional layer of anionic and hydrophilic hyaluronic acid as an inner layer improved protein-repelling behaviour, due to the formation of a highly hydrated layer in combination with steric hindrance. The last part of the Doctoral Dissertation deals with the preliminary assessment of real applications. For this purpose, real samples were used, i.e. materials, which are among the most commonly used as medical devices, namely, PDMS and medical stainless steel AISI 316LVM in the form of discs. The biocompatibility using mouse fibroblasts L929 and antimicrobial activity against Escherichia coli and Staphylococcus aureus were studied using PDMS and AISI 316LVM medical grade stainless steel as real materials with applied coatings, to show the applicability of the developed coatings on real, not only model surfaces. Bioactive coatings on biomaterial surfaces were confirmed by ATR-FTIR and with a change in the water contact angle. Although coatings provide antibiofilm properties in all cases, coating PDMS/Chi-77KS/HA lowered the presence of bacteria by 85% in the case of Escherichia coli, while PDMS/Chi-77KS/AMOX improved the antibiofilm behaviour by 81%. To conclude, all coatings are biocompatible, based on the criteria of ISO 10993-5 under the applied conditions.

Author : Adriano Piattelli
Publisher : Woodhead Publishing
Page : 286 pages
File Size : 37,47 MB
Release : 2016-10-27
Category : Technology & Engineering
ISBN : 0081002882

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Bone Response to Dental Implant Materials examines the oral environment and the challenges associated with dental biomaterials. Understanding different in vivo and in vitro responses is essential for engineers to successfully design and tailor implant materials which will withstand the different challenges of this unique environment. This comprehensive book reviews the fundamentals of bone responses in a variety of implant materials and presents strategies to tailor and control them. Presents a specific focus on the development and use of biomaterials in the oral environment Discusses the basic science of the dental interface and its clinical applications Contains important coverage on the monitoring and analysis of the dental implant interface

Author : Bingyun Li
Publisher : Springer Nature
Page : 648 pages
File Size : 24,89 MB
Release : 2020-03-02
Category : Medical
ISBN : 3030344754

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This book covers the latest research in biofilm, infection, and antimicrobial strategies in reducing and treating musculoskeletal, skin, transfusion, implant-related infections, etc. Topics covered include biofilms, small colony variants, antimicrobial biomaterials (antibiotics, antimicrobial peptides, hydrogels, bioinspired interfaces, immunotherapeutic approaches, and more), antimicrobial coatings, engineering and 3D printing, antimicrobial delivery vehicles, and perspectives on clinical impacts. Antibiotic resistance, which shifts the race toward bacteria, and strategies to reduce antibiotic resistance, are also briefly touched on. Combined with its companion volume, Racing for the Surface: Pathogenesis of Implant Infection and Advanced Antimicrobial Strategies, this book bridges the gaps between infection and tissue engineering, and is an ideal book for academic researchers, clinicians, industrial engineers and scientists, governmental representatives in national laboratories, and advanced undergraduate students and post-doctoral fellows who are interested in infection, microbiology, and biomaterials and devices.

Author : Iulian Vasile Antoniac
Publisher : Springer
Page : 0 pages
File Size : 29,94 MB
Release : 2016-05-05
Category : Technology & Engineering
ISBN : 9783319124599

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This handbook describes several current trends in the development of bioceramics and biocomposites for clinical use in the repair, remodelling, and regeneration of bone tissue. Comprehensive coverage of these materials allows fundamental aspects of the science and engineering to be seen in close relation to the clinical performance of dental and orthopaedic implants. Bioceramics and biocomposites appear to be the most dynamic area of materials development for both tissue engineering and implantable medical devices. Almost all medical specialties will continue to benefit from these developments, but especially dentistry and orthopaedics. In this Handbook, leading researchers describe the use of bionanomaterials to create new functionalities when interfaced with biological molecules or structures. Also described are technologies for bioceramics and biocomposites processing in order to fabricate medical devices for clinical use. Another important section of the book is dedicated to tissue regeneration with development of new matrices. A targeted or personalized treatment device reduces drug consumption and treatment expenses, resulting in benefits to the patient and cost reductions for public health systems. This authoritative reference on the state-of-the-art in the development and use of bioceramics and biocomposites can also serve as the basis of instructional course lectures for audiences ranging from advanced undergraduate students to post-graduates in materials science and engineering and biomedical engineering.