[PDF] Neuropeptide Research Trends eBook

Author : Bernice A. Levine
Publisher : Nova Publishers
Page : 316 pages
File Size : 32,85 MB
Release : 2007
Category : Medical
ISBN : 9781600216404

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The explosion of research activity in the field of neuropeptides has led to the idenfication of numerous naturally occurring endogenous peptides which act as neurotransmitters, neuromodulators, or trophic factors, to mediate nervous system functions. Increasing numbers of non-peptide ligands of neuropeptide receptors have been developed, which act as agonists or antagonists in peptidergic systems. The scope of this book includes gene regulation of peptide expression, peptide receptor subtypes, transgenic and knockout mice with mutations in genes for neuropeptides and peptide receptors, neuroanatomy, physiology, behaviour, neurotrophic factors, preclinical drug evaluation, clinical studies, and clinical trials.

Author : Döhler
Publisher : Birkhäuser
Page : 162 pages
File Size : 29,8 MB
Release : 2013-11-21
Category : Science
ISBN : 303485692X

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As early as in the twenties and thirties of our century Ernst Scharrer published papers suggesting, on the basis of morphological findings, that the brain exhibits secretory function which he called neurosecretion. Only a few decades later Scharrer's presumption was fully confirmed by the isolation of a number of neuropeptides and by the disclosure of their chemical stuctures. Neuropeptide research is one of the most rapidly expanding fields in biomedicin. Initially investigators focused their attention on the existence and role of neuropeptides within the hypothalamo-hypophyseal system. This particular area of research still provides plenty of interesting and fruitful findings. Neuropeptides -including those which were discovered as "hypothalamic" hormones can also be detected in other parts of the brain and even in peripheral organs. In fact, several neuropeptides were found to be synthesized not only by neurones but also by non-neuronal cells. These observations imply much wider functional relevance of neuropeptides than it had been supposed initially. It appears from present day knowledge, that neuropeptides are not only involved in neurotransmission and in the control of pituitary function but also in direct regulation of numerous peripheral biological processes, including reproduction, digestion, immune functions, and even cell growth. This volume includes the invited papers of the Symposium on "Progress in Neuropeptide Research" wh ich was held in Looz/Poland on September 8-10,1988. Topics ofthe symposium reflect upon newly discovered peptides, new localizations, new functions, and new technical approaches.

Author : Klaus H. Hoffmann
Publisher : Frontiers Media SA
Page : 163 pages
File Size : 25,23 MB
Release : 2020-09-17
Category : Medical
ISBN : 2889660176

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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Author : Adalberto Merighi
Publisher : Humana Press
Page : 416 pages
File Size : 39,11 MB
Release : 2011-09-16
Category : Medical
ISBN : 9781617793110

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Since the early days, the field of neuropeptide biology has dramatically widened, and today the ultimate frontiers in neuropeptide research lie in the development of pharmacologically active compounds that are capable of crossing the blood-brain barrier to exert their biological role(s) in vivo and in the construction of genetic vectors to be employed in gene therapy. Neuropeptides: Methods and Protocols presents a readily reproducible collection of established and emerging techniques for neuropeptide research as contributed by expert researchers in the field. The detailed methods presented cover subjects such as immunocytochemical localization, biochemical characterization, functional analysis, development and production of genetic probes, and the design of neuropeptide derivatives for cellular neurobiology as well as the potential therapeutic applications. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and easy to follow, Neuropeptides: Methods and Protocols is intended for a large audience of scientists, including histologists, biochemists, cellular and molecular biologists, and electrophysiologists that are currently active in the field or are willing to enter this exciting and still expanding area of neurobiology.

Author : Illana Gozes
Publisher : Springer Science & Business Media
Page : 167 pages
File Size : 48,4 MB
Release : 2007-11-13
Category : Medical
ISBN : 1588294684

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Neuropeptides exhibit multiple functions as hormones and regulators. As such, many techniques are required to understand the contribution and functions of neuropeptides in health and disease processes. Research in the neuropeptide field is aimed toward a better understanding of the physiology of the human body and toward the development of better diagnostics and therapeutics. This book will familiarize the audience with forefront techniques in the field.

Author : Fleur L. Strand
Publisher : MIT Press
Page : 678 pages
File Size : 16,79 MB
Release : 1999
Category : Neuropeptides
ISBN : 9780262194075

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This textbook is the first to bring together and synthesize the neuropeptide research of the past decade in such a comprehensive, scholarly manner. In recent years there has been increasing interest and, subsequently, active research in neuropeptides. These neuroactive molecules coordinate, integrate, and regulate physiological processes in all organisms, throughout all phases of development. Acting as neurohormones, neurotransmitters, and/or neuromodulators, they maintain physiological homeostasis and influence important behavioral patterns. This textbook is the first to bring together and synthesize the neuropeptide research of the past decade in such a comprehensive, scholarly manner. The book is divided into two parts. In Part I the author defines the basic principles of neuropeptide action, including their biosynthesis, processing, transport, distribution, and interactions with receptors and second messenger systems. Strand also discusses the intimate interaction between the neuropeptides, stress, and the immune system. In Part II she discusses the regulatory functions of the families of neuropeptide in sufficient detail to provide both the advanced student and senior investigator with a thorough understanding of the most important neuropeptides. The text also contains a complete and up-to-date reference/reading list.

Author : Elizabeth P. Farley
Publisher : Nova Publishers
Page : 308 pages
File Size : 47,11 MB
Release : 2007
Category : Medical
ISBN : 9781600216428

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The explosion of research activity in the field of neuropeptides has led to the identification of numerous naturally occurring endogenous peptides which act as neurotransmitters, neuromodulators, or trophic factors, to mediate nervous system functions. Increasing numbers of non-peptide ligands of neuropeptide receptors have been developed, which act as agonists or antagonists in peptidergic systems. The scope of this new and important book includes gene regulation of peptide expression, peptide receptor subtypes, transgenic and knockout mice with mutations in genes for neuropeptides and peptide receptors, neuroanatomy, physiology, behaviour, neurotrophic factors, preclinical drug evaluation, clinical studies, and clinical trials.

Author : S.H. Parvez
Publisher : Elsevier
Page : 436 pages
File Size : 24,11 MB
Release : 2013-10-22
Category : Science
ISBN : 1483290220

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This two-part book provides the most advanced biochemical and histochemical analytical methods on neurotransmitters, neuromodulators, and neuropeptides described by international specialists. The biochemical methods include liquid chromatography/electrochemistry, liquid chromatography/fluorescence and chemiluminescence detection, gas chromatography or liquid chromatography with mass spectrometry, and immunoassays. Morphological and physiological methods are also described, including immunohistochemistry, in situ hybridization, in vivo microdialysis, electrophysiological analysis, microwave irradiation, electrophysiological analysis, micro-anatomical dissection, peptide sequence analysis, quantitative autoradiographic analysis, and isolated CNS preparations. The neurotransmitters and neuropeptides include catecholamines, indoleamines, histamine, polyamines, and various neuropeptides, and their related enzymes. The book is the most comprehensive, advanced and versatile volume on the biochemical, morphological and physiological analysis of neurotransmitters and neuropeptides.

Author : Klaus H. Hoffmann
Publisher :
Page : 0 pages
File Size : 37,95 MB
Release : 2020
Category :
ISBN :

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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Author : John P. Bilezikian
Publisher : Academic Press
Page : 2074 pages
File Size : 28,88 MB
Release : 2008-09-29
Category : Medical
ISBN : 0080568750

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Principles of Bone Biology provides the most comprehensive, authoritative reference on the study of bone biology and related diseases. It is the essential resource for anyone involved in the study of bone biology. Bone research in recent years has generated enormous attention, mainly because of the broad public health implications of osteoporosis and related bone disorders. Provides a "one-stop" shop. There is no need to search through many research journals or books to glean the information one wants...it is all in one source written by the experts in the field The essential resource for anyone involved in the study of bones and bone diseases Takes the reader from the basic elements of fundamental research to the most sophisticated concepts in therapeutics Readers can easily search and locate information quickly as it will be online with this new edition