[PDF] Neuronal Morphogenesis eBook

Author : Neal T. Sweeney
Publisher :
Page : 260 pages
File Size : 41,51 MB
Release : 2006
Category :
ISBN :

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Proper dendritic branching is required for neuronal function. Although a number of genes that regulate dendritic branching have recently been identified, the mechanisms by which these genes control morphogenesis remain unknown. As many genes are expressed in multiple tissues and at multiple developmental time points, it is important to determine the specific cell-autonomous roles for a particular gene in dendritic branching, independent of pleiotropic effects.

Author : David J. Price
Publisher : John Wiley & Sons
Page : 652 pages
File Size : 32,27 MB
Release : 2017-09-25
Category : Medical
ISBN : 1119293715

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Provides a highly visual, readily accessible introduction to the main events that occur during neural development and their mechanisms Building Brains: An Introduction to Neural Development, 2nd Edition describes how brains construct themselves, from simple beginnings in the early embryo to become the most complex living structures on the planet. It explains how cells first become neural, how their proliferation is controlled, what regulates the types of neural cells they become, how neurons connect to each other, how these connections are later refined under the influence of neural activity, and why some neurons normally die. This student-friendly guide stresses and justifies the generally-held belief that a greater knowledge of how nervous systems construct themselves will help us find new ways of treating diseases of the nervous system that are thought to originate from faulty development, such as autism spectrum disorders, epilepsy, and schizophrenia. A concise, illustrated guide focusing on core elements and emphasizing common principles of developmental mechanisms, supplemented by suggestions for further reading Text boxes provide detail on major advances, issues of particular uncertainty or controversy, and examples of human diseases that result from abnormal development Introduces the methods for studying neural development, allowing the reader to understand the main evidence underlying research advances Offers a balanced mammalian/non-mammalian perspective (and emphasizes mechanisms that are conserved across species), drawing on examples from model organisms like the fruit fly, nematode worm, frog, zebrafish, chick, mouse and human Associated Website includes all the figures from the textbook and explanatory movies Filled with full-colorartwork that reinforces important concepts; an extensive glossary and definitions that help readers from different backgrounds; and chapter summaries that stress important points and aid revision, Building Brains: An Introduction to Neural Development, 2nd Edition is perfect for undergraduate students and postgraduates who may not have a background in neuroscience and/or molecular genetics. “This elegant book ranges with ease and authority over the vast field of developmental neuroscience. This excellent textbook should be on the shelf of every neuroscientist, as well as on the reading list of every neuroscience student.” —Sir Colin Blakemore, Oxford University “With an extensive use of clear and colorful illustrations, this book makes accessible to undergraduates the beauty and complexity of neural development. The book fills a void in undergraduate neuroscience curricula.” —Professor Mark Bear, Picower Institute, MIT. Highly Commended, British Medical Association Medical Book Awards 2012 Published with the New York Academy of Sciences

Author : Hirokawa
Publisher : CRC-Press
Page : 300 pages
File Size : 35,1 MB
Release : 1994-01-01
Category : Medical
ISBN : 9780849377419

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This book discusses the primary functions of microtubule-associated proteins (MAPs) such as MAP2 and tau in neuronal morphogenesis, as well as relationships between neuronal differentiation and the expression of neuronal intermediate filaments (nestin, alpha internexin, and neurofilament triplet proteins). It emphasizes the importance of several cytoskeletal proteins for neuronal differentiation and morphogenesis, organelle transport, and synaptic functions. The book considers the involvement of tau MAPs in the formation of paired helical filaments in Alzheimer's disease, and it examines the mechanisms of organelle transports and molecular motors such as kinesin, braindynein, and kinesin superfamily proteins. Cytoskeletal proteins involved in synaptic formation and transmitter release and new synaptic junctional-associated proteins are explored as well.

Author : Jamie Davies
Publisher : Springer Science & Business Media
Page : 255 pages
File Size : 22,13 MB
Release : 2007-03-20
Category : Science
ISBN : 0387308733

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Branching morphogenesis, the creation of branched structures in the body, is a key feature of animal and plant development. This book brings together, for the first time, expert researchers working on a variety of branching systems to present a state-of-the-art view of the mechanisms that control branching morphogenesis. Systems considered range from single cells, to blood vessel and drainage duct systems to entire body plans, and approaches range from observation through experiment to detailed biophysical modelling. The result is an integrated overview of branching.

Author : Ira Black
Publisher : Springer Science & Business Media
Page : 376 pages
File Size : 49,68 MB
Release : 2013-11-11
Category : Medical
ISBN : 1461327172

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A central problem in neurobiology concerns mechanisms that generate the pro found diversity and specificity of the nervous system. What is the substance of diversification and specificity at the molecular, cellular, and systems levels? 4 How, for example, do 1011 neurons each form approximately 10 interconnec tions, allowing normal physiological function? How does disruption of these processes result in human disease? These proceedings represent the efforts of molecular biologists, embryologists, neurobiologists, and clinicians to approach these issues. in this volume are grouped by subject to present the varieties The chapters of methods used to approach each individual area. Section I deals with embry ogenesis and morphogenesis of the nervous system. In Chapter 3, Weston and co-workers describe the use of monoclonal antibodies that recognize specific neuronal epitopes (including specific gangliosides) for the purpose of defining heterogeneity in the neural crest, an important model system. Immunocyto chemical analysis reveals the existence of distinct sUbpopulations within the crest at extremely early stages; cells express neuronal or glial binding patterns at the time of migration. Consequently, interactions with the environment may select for predetermined populations. Le Douarin reaches similar conclusions in Chapter 1 by analyzing migratory pathways and developmental potentials in crest of quail-