[PDF] Mutagenicity Carcinogenicity And Teratogenicity Of Industrial Pollutants eBook

Author : Micheline Kirsch-Volders
Publisher : Springer Science & Business Media
Page : 348 pages
File Size : 39,97 MB
Release : 2012-12-06
Category : Medical
ISBN : 1461326435

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This book is intended for anyone who cares about the health of people exposed to industrial pollutants. Attention is given to those pollutants which present a possible risk to the genetic material of exposed workers. Chapters are devoted to heavy metals such as arsenic, beryllium, cadmium, chromium, lead, mercury, nickel, etc.; insecticides (chlorinated, organophosphorus, and carbonate insecticides); monomers such as vinyl-chloride, acrylonitrile, styrene, vinylidene chloride, butadiene, chlorobutadiene, hexachlorobuta diene, etc.; and halogenated hydrocarbon solvents such as chloroform, carbon tetrachloride, trichloroethylene, I, 2-dichloroethane, tetrachloroethyl ene, dichloromethane, and I, I, I-trichloroethane. The main aim of this work is to provide the physician, the biologist, the pharmacologist, or anyone involved in genetic toxicology with a useful compendium of up-to-date information and references. Efforts are made to open the field to nonspecialists. An introductory chapter deals with the mechanisms whereby a given compound, reaching genetic material, either directly or indirectly, may increase the risk of a cancer developing in the exposed individual and of abnormalities being passed on to his or her progeny. Efforts are also made to allow easy and efficient reading for those who are not interested in detailed results. Comparative tables provide the following data on the compounds studied: chemical properties, production, occurrence, accepted standards in the industry, and positive or negative results with different test systems. Finally, senior research workers might find good descriptions in this book of the most recent results from mutagenesis and carcinogenesis testing in plant, nonmammalian, and mammalian systems.

Author : United States. Public Health Service. Office of the Surgeon General
Publisher :
Page : 728 pages
File Size : 19,83 MB
Release : 2010
Category : Government publications
ISBN :

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This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.

Author : Vera M. Kolb
Publisher : Elsevier
Page : 595 pages
File Size : 16,47 MB
Release : 2013-10-22
Category : Medical
ISBN : 1483193225

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Teratogens Chemicals Which Cause Birth Defects, 2nd Revised Edition is a collection of papers that discusses the practical aspect of teratogens, particularly regarding information on the teratogenic potential of chemicals. This book describes the principles and mechanism of teratogenesis, including the initiating mechanisms during the subcellular or molecular level and the role of bio-activation in teratogenesis. Investigations have been done on the relationship between spontaneous abortion in women exposed to organic solvents, antineoplastic agents, and chemicals in plastics. Other studies also show that teratogenicity depends in part on enzymatic bio-activation to an embryotoxic reactive intermediate. This text also explains the legal and ethical aspects of fetal protection policies with emphasis on fetal protection. Protection to expecting women extends to pregnant students exposed to teratogenic chemicals in chemistry laboratories. The book explains how and where to get information about the teratogenic potential of chemicals and how to properly handle these chemicals in the laboratory. The book also provides a list from RTECs of toxic chemicals which can cause reproductive effects. This book can prove useful for chemists, pharmacologists, obstetricians, gynecologists, and practitioners of general medicine.