[PDF] Mutagenicity eBook

Author : Ashutosh Kumar
Publisher : Academic Press
Page : 352 pages
File Size : 34,14 MB
Release : 2017-09-26
Category : Science
ISBN : 0128092602

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Mutagenicity: Assays and Applications presents an extensive examination of the detection, assessment and future of mutagenicity, particularly as it concerns human health and the environment. Chapters focused on specific types of mutagens or testing methods for their detection collectively explore the current state of human and environmental mutagenesis, future perspectives and regulatory needs. The test procedures for measuring mutagenicity, their advantages and limitations are described with practical and procedural detail, along with their presentation and data processing aspects. It is an essential reference covering the breadth and depth of the field of mutagenicity studies and regulation. By providing both important introductory material and practical assays and applications, this book is useful to graduate students, academic and industry researchers and regulators at various stages of their careers, leading to improved risk assessment and regulation. Presents an up-to-date and in-depth review of the current state of mutagenesis research Draws upon the combined experience and expertise of an international group of highly respected editors and chapter authors Provides an introduction to the concept of mutagenesis with particular consideration given to novel chemicals and materials

Author : John A. Heddle
Publisher : Elsevier
Page : 490 pages
File Size : 11,77 MB
Release : 2013-10-22
Category : Medical
ISBN : 1483271226

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Mutagenicity: New Horizons in Genetic Toxicology provides an overview of the various applications and studies in the field of genetic toxicology and environmental mutagenesis. The book is composed of selected scientific papers written by experts in the field. The text presents topics on naturally occurring mutagens; occupational carcinogen; and evaluation of cooking methods. Experiments on mammalian cell mutation; chromosomal aberrations; and organisms that can be used as environmental monitors of toxicity are discussed as well. Ecologists, environmental and sanitary engineers, toxicologists, and anyone interested in environmental mutagenesis, genetic toxicology, occupational health, or the regulation of toxic substances will find the book a good source of insight.

Author : Samuel S. Epstein
Publisher : MIT Press (MA)
Page : 248 pages
File Size : 50,71 MB
Release : 1971
Category : Chemical mutagenesis
ISBN :

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This is the first book to present recently developed mammalian methodologies for evaluating mutagenic hazards of chemicals such as pesticides.

Author : OECD
Publisher : OECD Publishing
Page : 12 pages
File Size : 43,28 MB
Release : 1997-07-21
Category :
ISBN : 9264071245

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The bacterial reverse mutation test uses amino-acid requiring at least five strains of Salmonella typhimurium and Escherichia coli to detect point mutations by base substitutions or frameshifts. The principle of this bacterial reverse mutation test ...

Author : Micheline Kirsch-Volders
Publisher : Springer Science & Business Media
Page : 348 pages
File Size : 20,87 MB
Release : 2012-12-06
Category : Medical
ISBN : 1461326435

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This book is intended for anyone who cares about the health of people exposed to industrial pollutants. Attention is given to those pollutants which present a possible risk to the genetic material of exposed workers. Chapters are devoted to heavy metals such as arsenic, beryllium, cadmium, chromium, lead, mercury, nickel, etc.; insecticides (chlorinated, organophosphorus, and carbonate insecticides); monomers such as vinyl-chloride, acrylonitrile, styrene, vinylidene chloride, butadiene, chlorobutadiene, hexachlorobuta diene, etc.; and halogenated hydrocarbon solvents such as chloroform, carbon tetrachloride, trichloroethylene, I, 2-dichloroethane, tetrachloroethyl ene, dichloromethane, and I, I, I-trichloroethane. The main aim of this work is to provide the physician, the biologist, the pharmacologist, or anyone involved in genetic toxicology with a useful compendium of up-to-date information and references. Efforts are made to open the field to nonspecialists. An introductory chapter deals with the mechanisms whereby a given compound, reaching genetic material, either directly or indirectly, may increase the risk of a cancer developing in the exposed individual and of abnormalities being passed on to his or her progeny. Efforts are also made to allow easy and efficient reading for those who are not interested in detailed results. Comparative tables provide the following data on the compounds studied: chemical properties, production, occurrence, accepted standards in the industry, and positive or negative results with different test systems. Finally, senior research workers might find good descriptions in this book of the most recent results from mutagenesis and carcinogenesis testing in plant, nonmammalian, and mammalian systems.

Author : OECD
Publisher : OECD Publishing
Page : 16 pages
File Size : 18,10 MB
Release : 2011-07-28
Category :
ISBN : 9264122818

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This Test Guideline describes an in vivo assay that detects chemicals that may induce gene mutations. In this assay, transgenic rats or mice that contain multiple copies of chromosomally integrated plasmid or phage shuttle vectors are used. The ...

Author : Sonia Soloneski
Publisher : BoD – Books on Demand
Page : 166 pages
File Size : 39,20 MB
Release : 2021
Category :
ISBN : 1838800417

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This edited book, "Genotoxicity and Mutagenicity - Mechanisms and Test Methods", aims to present the latest developments from different fields, highlighting the detrimental influence that mutagenic and genotoxic agents inflict on DNA and how antimutagenic and anticarcinogenic modulators are able to reduce the negative impact of such toxic agents on living species.

Author : David J. Kirkland
Publisher : Cambridge University Press
Page : 164 pages
File Size : 13,92 MB
Release : 1990-08-31
Category : Medical
ISBN : 9780521393478

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A summary of the essential texts that must be performed on all new compounds before they can be registered for use in the UK.

Author : National Research Council
Publisher : Legare Street Press
Page : 0 pages
File Size : 46,75 MB
Release : 2022-10-27
Category : History
ISBN : 9781015691629

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This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work is in the "public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.

Author : B.J. Kilbey
Publisher : Elsevier
Page : 876 pages
File Size : 37,33 MB
Release : 2012-12-02
Category : Medical
ISBN : 0444600981

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The compilation of this book was prompted by the necessity of a bench volume which could provide the necessary background information on materials, experimental design, pitfalls and dificulties, in order to perform a particular test in an acceptable way with a minimal need for additional expert help. This Second Edition updates this information, providing: - a comprehensive bench guide - methods known to be reliable - a broad spectrum of approaches - tips to avoid pitfalls when using unfamiliar techniques - data from population records - safety aspects of mutagens and carcinogens - basic statistical concepts for experiment design This `on the bench' methodological text provides the necessary information for most of the common assays for genetic damage in use. The book includes methods which have been sufficiently used and tested to make their use reliable, but also presents methods which are not widely used at present, but which might prove most useful in screening for mutagenic effects.