[PDF] Multipoint Mapping And Linkage Based Upon Affected Pedigree Members eBook

Author : Robert C. Elston
Publisher : John Wiley & Sons
Page : 258 pages
File Size : 20,15 MB
Release : 1989
Category : Science
ISBN :

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Using both empirical and simulated data, this study examines selected computational approaches and algorithms for analyzing the genetic etiology of a disease. It compares a wide variety of analytical methods and highlights areas of substantive interest to geneticists investigating human disease. Its methodologic emphasis provides useful guidance for the design of future studies to map disease susceptibility loci.

Author : Daniel E. Weeks
Publisher :
Page : 6 pages
File Size : 18,38 MB
Release : 1992
Category :
ISBN :

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Human geneticists have been extremely successful in the past decade in mapping rare disease genes. For common diseases with a substantial genetic component, the payoff for human health is larger, but the mapping problems are harder. There is a need for robust statistical techniques that require minimal assumptions about the mode of inheritance of the disease studied. The affected-pedigree-member (APM) of linkage analysis makes virtually no assumptions about disease transmission except that it is independent of marker transmission in a pedigree. We discuss here an extension of the APM method from single markers to multiple closely linked markers. This extension should improve the power of the APM method to detect linkage.

Author : David J. Balding
Publisher : John Wiley & Sons
Page : 1828 pages
File Size : 42,51 MB
Release : 2019-07-09
Category : Science
ISBN : 1119429250

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A timely update of a highly popular handbook on statistical genomics This new, two-volume edition of a classic text provides a thorough introduction to statistical genomics, a vital resource for advanced graduate students, early-career researchers and new entrants to the field. It introduces new and updated information on developments that have occurred since the 3rd edition. Widely regarded as the reference work in the field, it features new chapters focusing on statistical aspects of data generated by new sequencing technologies, including sequence-based functional assays. It expands on previous coverage of the many processes between genotype and phenotype, including gene expression and epigenetics, as well as metabolomics. It also examines population genetics and evolutionary models and inference, with new chapters on the multi-species coalescent, admixture and ancient DNA, as well as genetic association studies including causal analyses and variant interpretation. The Handbook of Statistical Genomics focuses on explaining the main ideas, analysis methods and algorithms, citing key recent and historic literature for further details and references. It also includes a glossary of terms, acronyms and abbreviations, and features extensive cross-referencing between chapters, tying the different areas together. With heavy use of up-to-date examples and references to web-based resources, this continues to be a must-have reference in a vital area of research. Provides much-needed, timely coverage of new developments in this expanding area of study Numerous, brand new chapters, for example covering bacterial genomics, microbiome and metagenomics Detailed coverage of application areas, with chapters on plant breeding, conservation and forensic genetics Extensive coverage of human genetic epidemiology, including ethical aspects Edited by one of the leading experts in the field along with rising stars as his co-editors Chapter authors are world-renowned experts in the field, and newly emerging leaders. The Handbook of Statistical Genomics is an excellent introductory text for advanced graduate students and early-career researchers involved in statistical genetics.

Author : Jurg Ott
Publisher : JHU Press
Page : 418 pages
File Size : 28,31 MB
Release : 1999-04-16
Category : Medical
ISBN : 9780801861406

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Introduction and basic genetic principles; Genetic loci genetic polymorphisms; Aspects of statistical inference; Basics of linkage analysis; The informativeness of family data; Multipoint linkage analysis; Penetrance; Quantitative phenotypes; Numerical and computerized methods; Variability of the recombination fraction; Inconsistencies; Linkage analysis with mendelian disease loci; Nonparametric methods; Two-locus inheritance; Complex traits.

Author : Joseph Douglas Terwilliger
Publisher : JHU Press
Page : 326 pages
File Size : 43,9 MB
Release : 1994-04
Category : Medical
ISBN : 9780801848032

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"A good reference for statisticians and other analysts becoming involved in the popular field of 'gene mapping'." -- "American Journal of Human Genetics"

Author : William K. Scott
Publisher : John Wiley & Sons
Page : 340 pages
File Size : 34,9 MB
Release : 2021-12-06
Category : Science
ISBN : 1118123913

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Genetic Analysis of Complex Diseases An up-to-date and complete treatment of the strategies, designs and analysis methods for studying complex genetic disease in human beings In the newly revised Third Edition of Genetic Analysis of Complex Diseases, a team of distinguished geneticists delivers a comprehensive introduction to the most relevant strategies, designs and methods of analysis for the study of complex genetic disease in humans. The book focuses on concepts and designs, thereby offering readers a broad understanding of common problems and solutions in the field based on successful applications in the design and execution of genetic studies. This edited volume contains contributions from some of the leading voices in the area and presents new chapters on high-throughput genomic sequencing, copy-number variant analysis and epigenetic studies. Providing clear and easily referenced overviews of the considerations involved in genetic analysis of complex human genetic disease, including sampling, design, data collection, linkage and association studies and social, legal and ethical issues. Genetic Analysis of Complex Diseases also provides: A thorough introduction to study design for the identification of genes in complex traits Comprehensive explorations of basic concepts in genetics, disease phenotype definition and the determination of the genetic components of disease Practical discussions of modern bioinformatics tools for analysis of genetic data Reflecting on responsible conduct of research in genetic studies, as well as linkage analysis and data management New expanded chapter on complex genetic interactions This latest edition of Genetic Analysis of Complex Diseases is a must-read resource for molecular biologists, human geneticists, genetic epidemiologists and pharmaceutical researchers. It is also invaluable for graduate students taking courses in statistical genetics or genetic epidemiology.

Author : National Research Council
Publisher : National Academies Press
Page : 388 pages
File Size : 35,42 MB
Release : 2001-01-19
Category : Social Science
ISBN : 0309171431

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What can social science, and demography in particular, reasonably expect to learn from biological information? There is increasing pressure for multipurpose household surveys to collect biological data along with the more familiar interviewer-respondent information. Given that recent technical developments have made it more feasible to collect biological information in non-clinical settings, those who fund, design, and analyze survey data need to think through the rationale and potential consequences. This is a concern that transcends national boundaries. Cells and Surveys addresses issues such as which biologic/genetic data should be collected in order to be most useful to a range of social scientists and whether amassing biological data has unintended side effects. The book also takes a look at the various ethical and legal concerns that such data collection entails.