[PDF] Multifunctional Nanocomposites For Targeted Drug Delivery In Cancer Therapy eBook

Author : Awesh K. Yadav
Publisher : Elsevier
Page : 435 pages
File Size : 32,9 MB
Release : 2023-12-01
Category : Computers
ISBN : 0323953042

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Multifunctional Nanocomposites for Targeted Drug Delivery in Cancer Therapy explores the design, synthesis, and application of different multifunctional nanocomposites drug delivery system for cancer treatment. It encompasses initial chapters discussing introductory information about cancer, followed by chapters focusing on the detailed information about various novel drug delivery systems for treatment of several organ site cancers such as prostate, skin, breast, lung, liver, pancreas, stomach, colon, blood, mouth and throat. It is a valuable resource for cancer researchers, oncologists, graduate students, and members of biomedical research who need to understand more about novel nanotechnologies applied to cancer treatment. Discusses a wide range of promising approaches for the diagnosis and treatment of cancer using the latest advancement in cutting-edge nanomedical technologies Presents chapters dedicated to each cancer type and the best nanocomposite therapies used, making the content easily discoverable by readers Written by world-renowned experts and researchers in the areas of nanomedicine, drug delivery and cancer research to explore thoroughly the topic with diverse perspectives

Author : Sabu Thomas
Publisher : Academic Press
Page : 0 pages
File Size : 35,28 MB
Release : 2025-01-01
Category : Computers
ISBN : 9780443216862

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Multifunctional Nanoparticles for Cancer Therapeutic Applications: Design and Challenges describes the use of multifunctional nanoparticles for cancer treatment, highlighting their toxicological evaluation and opportunities for prospective clinical therapeutic development. Besides significant research and clinical success, cancer nanomedicines currently face challenges towards clinical translation and this book aims to shed a light on complex issues. It discusses topics such as synthetic strategies and functionalization of nanoparticles; routes of administration; biological barriers and how to overcome them; nanoparticles for cancer treatment available in the market; active targeting approach; non-viral gene-based therapy with multifunctional nanoparticles; and the use of nanoparticles in immunotherapy. In addition, it discusses image guided cancer therapy; stem cell targeted therapy; and toxicity. It is a valuable resource for cancer researchers, oncologists, clinicians, and members of biomedical field who need to understand the potential of multifunctional nanoparticles in cancer drug delivery, diagnosis, and treatment.

Author : Feng Wang
Publisher :
Page : 130 pages
File Size : 46,52 MB
Release : 2013
Category :
ISBN :

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With the advancement of nanotechnology, cancer therapy requires that the carrier at nanoscale integrates cell targeting, imaging, drug storage and controlled drug release simultaneously. Extensive efforts have been devoted to isotropic sphere nanoparticle based carrier systems for their uniform surface properties. However, multifunctionality also leads to a challenge issue: different moieties may interfere with each other in bioconjugation process due to the similar conjugation chemistry applied to the same surface. As a result, Janus nanoparticles which are anisotropic in shape, composition or surface chemistry have attracted increasing attention. Asymmetric composition could achieve multifunctionality simultaneously. More importantly, surfaces could be selectively loaded with targeting ligands, imaging probes or drugs, which made the Janus nanoparticles "truly multifunctional entities." A variety of fabrication methods have been studied to synthesize Janus nanoparticles for applications such as surfactants, magnetic-fluorescent display or imaging, and catalysts, etc. In contrast, exploration in the biomedical application field is rather limited. Based on our previous work on iron oxides@polystyrene matrix multifunctional nanoparticles and yolk-shell nanocomposites, we designed the polystyrene/Fe3O4@SiO2 superparamagnetic Janus nanocomposites (SJNCs). The SJNCs (~300 nm) are composed of a polystyrene (PS) core and a silica half shell embedded with iron oxide nanoparticles. We demonstrated the innovative dual functionalities on independent surfaces were obtained simultaneously during one-pot facile synthesis, which is much more convenient than the previous report on generating the similar structure through selectively coating. PS surfaces were decorated with carboxyl groups and silanol groups on silica surfaces provided enormous opportunities for further functionalization. To achieve cell targeting and controlled drug release, we conjugated folic acid (FA) to the PS and doxorubicin (DOX), an anti-cancer drug to the silica via a pH-sensitive hydrazone bond (FA-SJNCs-DOX). Drug release behaviors in different buffer solutions (pH 5.0, 6.0 and 7.4) displayed clear pH dependence. To evaluate the in vitro cell targeting and drug release, cell cytotoxicity of FA-SJNCs-DOX against human breast cancer line MDA-MB-231 was tested. Significant difference of the concentrations killing 50 % of the cells (IC50) was observed from targeted and non-targeted group. It is hypothesized that targeted nanocomposites (FA-SJNCs-DOX) could be internalized by cancer cells via folate receptor mediated endocytosis and release the drug at a faster rate in endocytic compartments (pH 4.5~6.5), compared to under physiological condition (pH 7.4) from the non-targeted group (SJNCs-DOX), thus providing highly localized controlled drug delivery. More interestingly, the incorporated iron oxides could provide potential application such as MRI, magnetic targeting and hyperthermia, thus making the Janus nanocomposites a truly versatile platform for wide biomedical application.

Author : Alexandru Mihai Grumezescu
Publisher : Elsevier
Page : 922 pages
File Size : 42,50 MB
Release : 2017-04-11
Category : Medical
ISBN : 0323461506

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Nanostructures for Cancer Therapy discusses the available preclinical and clinical nanoparticle technology platforms and their impact on cancer therapy, including current trends and developments in the use of nanostructured materials in chemotherapy and chemotherapeutics. In particular, coverage is given to the applications of gold nanoparticles and quantum dots in cancer therapies. In addition to the multifunctional nanomaterials involved in the treatment of cancer, other topics covered include nanocomposites that can target tumoral cells and the release of antitumoral therapeutic agents. The book is an up-to-date overview that covers the inorganic and organic nanostructures involved in the diagnostics and treatment of cancer. Provides an examination of nanoparticle delivery systems for cancer treatment, illustrating how the use of nanotechnology can help provide more effective chemotherapeutic treatments Examines, in detail, the different types of nanomaterials used in cancer therapy, also explaining the effect of each Provides a cogent overview of recent developments in the use of nanostructured materials in chemotherapeutics, allowing readers to quickly familiarize themselves with this area

Author : Sonke Svenson
Publisher : Springer Science & Business Media
Page : 371 pages
File Size : 11,40 MB
Release : 2012-02-22
Category : Technology & Engineering
ISBN : 1461423058

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This book clearly demonstrates the progression of nanoparticle therapeutics from basic research to applications. This book, unlike others covering nanoparticles used in medical applications, presents the medical challenges that can be reduced or even overcome by recent advances in nanoscale drug delivery. Each chapter highlights recent progress in the design and engineering of select multifunctional nanoparticles with topics covering targeting, imaging, delivery, diagnostics, and therapy.

Author : Muthupandian Saravanan
Publisher : Springer Nature
Page : 362 pages
File Size : 15,84 MB
Release : 2021-10-05
Category : Medical
ISBN : 3030743306

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Nanotechnology is an interdisciplinary research field that integrates chemistry, engineering, biology, and medicine. Nanomaterials offer tremendous opportunity as well as challenges for researchers. Of course, cancer is one of the world's most common health problems, responsible for many deaths. Exploring efficient anticancer drugs could revolutionize treatment options and help manage cancer mortality. Nanomedicine plays a significant role in developing alternative and more effective treatment strategies for cancer theranostics. This book mainly focuses on the emerging trends using nanomaterials and nanocomposites as alternative anticancer material’s. The book is divided into three main topic areas: how to overcome existing traditional approaches to combat cancer, applying multiple mechanisms to target the cancer cells, and how nanomaterials can be used as effective carriers. The contents highlight recent advances in interdisciplinary research on processing, morphology, structure, and properties of nanostructured materials and their applications to combat cancer.Cancer Nanotheranostics is comprehensive in that it discusses all aspects of cancer nanotechnology. Because of the vast amount of information, it was decided to split this material into two volumes. In the first volume of Cancer Nanotheranostics, we discuss the role of different nanomaterials for cancer therapy, including lipid-based nanomaterials, protein and peptide-based nanomaterials, polymer-based nanomaterials, metal-organic nanomaterials, porphyrin-based nanomaterials, metal-based nanomaterials, silica-based nanomaterials, exosome-based nanomaterials and nano-antibodies. In the second volume, we discuss the nano-based diagnosis of cancer, nano-oncology for clinical applications, nano-immunotherapy, nano-based photothermal cancer therapy, nano-erythrosomes for cancer drug delivery, regulatory perspectives of nanomaterials, limitations of cancer nanotheranostics, the safety of nano-biomaterials for cancer nanotheranostics, multifunctional nanomaterials for targeting cancer nanotheranostics, and the role of artificial intelligence in cancer nanotheranostics.

Author : Rongqin Huang
Publisher : Springer Nature
Page : 462 pages
File Size : 36,54 MB
Release : 2020-09-28
Category : Medical
ISBN : 9811551596

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This book summarizes the latest advances in nanomaterials and techniques in the field of tumor-targeted diagnosis and therapy. It provides valuable information for beginners and senior researchers, and stimulates new research directions by offering novel and provocative insights into the properties and technical principles of nanomaterials. The book systemically discusses the challenges in tumor treatment, current tumor-targeted strategies, drug-release strategies, diagnosis and therapeutic patterns, and also explores newly developed multifunctional nanomaterials and related systems.

Author : Barkat, Md. Abul
Publisher : IGI Global
Page : 624 pages
File Size : 48,32 MB
Release : 2018-01-12
Category : Technology & Engineering
ISBN : 1522547827

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Advances in technology permeates every aspect of life, including the healthcare system. Nanotechnology based systems have gained popularity based upon their promise, size, and other characteristics. Multifunctional Nanocarriers for Contemporary Healthcare Applications is a critical academic publication that explores advancements in nanostructured systems, applications of these systems in healthcare, and biomedical applications of these systems. Featuring coverage on a wide range of topics, such as hydrogels, controlled drug delivery systems, and nanomedicine, this book is geared toward researchers, students, and academicians seeking current research on advancements and applications of nanostructured systems in the healthcare industry.

Author : Alexandru Grumezescu
Publisher : William Andrew
Page : 0 pages
File Size : 10,65 MB
Release : 2016-05-30
Category : Technology & Engineering
ISBN : 0323428630

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Nanobiomaterials in Cancer Therapy

Author : Malay K. Das
Publisher : Academic Press
Page : 428 pages
File Size : 29,64 MB
Release : 2021-03-16
Category : Business & Economics
ISBN : 0128217006

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Multifunctional Theranostic Nanomedicines in Cancer focuses on new trends, applications, and the significance of novel multifunctional nanotheranostics in cancer imaging for diagnosis and treatment. Cancer nanotechnology offers new opportunities for cancer diagnosis and treatment. Multifunctional nanoparticles harboring various functions—including targeting, imaging, and therapy—have been intensively studied with the goal of overcoming the limitations of conventional cancer diagnosis and therapy. Thus theranostic nanomedicines have emerged in recent years to provide an efficient and safer alternative in cancer management. This book covers polymer-based therapies, lipid-based therapies, inorganic particle-based therapies, photo-related therapies, radiotherapies, chemotherapies, and surgeries. Multifunctional Theranostic Nanomedicines in Cancer offers an indispensable guide for researchers in academia, industry, and clinical settings; it is also ideal for postgraduate students; and formulation scientists working on cancer. Provides a comprehensive resource of recent scientific progress and novel applications of theranostic nanomedicines Discusses treatment options from a pharmaceutical sciences perspective Includes translational science and targeted CNS cancer treatment