[PDF] Mucoadhesive Materials And Drug Delivery Systems eBook

Author : Vitaliy V. Khutoryanskiy
Publisher : John Wiley & Sons
Page : 424 pages
File Size : 30,49 MB
Release : 2014-06-12
Category : Science
ISBN : 1118794397

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Mucoadhesion defined as attachment of synthetic or natural materials to mucosal tissues has been widely exploited in pharmaceutical forms. This multi-author book provides an up-to-date account of current research on mucoadhesive materials and drug delivery systems. The introductory section describes the structure and physiology of various mucosal surfaces (oral, nasal, ocular, gastrointestinal and vaginal mucosa). This is followed by chapters on the various methods used to study mucoadhesion and to characterise mucoadhesive properties of various dosage forms. The final section will summarise information on traditional and novel types of mucoadhesive materials, such as chitosan, thiomers, and liposome-based formulations. This book is unique as there is currently no modern book considering mucoadhesion - all other existing books on the topic are either narrowly focused or more than 10 years old. Furthermore, each contributor offers specialist perspectives from a variety of global locations in both industrial and academic research centres.

Author : Edith Mathiowitz
Publisher : CRC Press
Page : 704 pages
File Size : 24,20 MB
Release : 1999-07-13
Category : Medical
ISBN : 9781420001341

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This invaluable reference presents a comprehensive review of the basic methods for characterizing bioadhesive materials and improving vehicle targeting and uptake-offering possibilities for reformulating existing compounds to create new pharmaceuticals at lower development costs. Evaluates the unique carrier characteristics of bioadhesive polymers and their power to enhance localization of delivered agents, local bioavailability, and drug absorption and transport! Written by over 50 international experts and reflecting broad knowledge of both traditional bioadhesive strategies and novel clinical applications, Bioadhesive Drug Delivery Systems discusses mechanical and chemical bonding, polymer-mucus interactions, the effect of surface energy in bioadhesion, polymer hydration, and mucus rheology analyzes biochemical properties of mucus and glycoproteins, cell adhesion molecules, and cellular interaction with two- and three-dimensional surfaces covers microbalances and magnetic force transducers, atomic force microscopy, direct measurements of molecular level adhesions, and methods to measure cell-cell interactions examines bioadhesive carriers, diffusion or penetration enhancers, and lectin-targeted vehicles describes vaginal, nasal, buccal, ocular, and transdermal drug delivery reviews bioadhesive interactions with the mucosal tissues of the eye and mouth, and those in the respiratory, urinary, and gastrointestinal tracts explores issues of product development, clinical testing, and production and more! Amply referenced with over 1400 bibliographic citations, and illustrated with more than 300 drawings, photographs, tables, and display equations, Bioadhesive Drug Delivery Systems serves as a sound basis for innovation in bioadhesive systems and an excellent introduction to the subject. This unique reference is ideal for pharmaceutical scientists and technologists; chemical, polymer, and plastics engineers; biochemists; physical, surface, and colloid chemists; biologists; and upper-level undergraduate and graduate students in these disciplines.

Author : K. L. Mittal
Publisher : John Wiley & Sons
Page : 432 pages
File Size : 28,80 MB
Release : 2020-05-12
Category : Technology & Engineering
ISBN : 1119640253

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Understanding the phenomenon of bioadhesion i.e. its theories or mechanism(s) are of critical importance in developing optimum bioadhesive polymers (used in bioadhesives). Such bioadhesive polymers are the key for exhibiting the process of bioadhesion, controlled/sustained release of drugs, and drug targeting. The use of bioadhesives restricts the delivery system to the site of interest and thus offers a useful and efficient technique for targeting a drug to the desired location for a prolonged duration. This book addresses the various relevant aspects of bioadhesives in drug delivery in an easily accessible and unified manner. The book containing 12 chapters written by eminent researchers from many parts of the globe is divided into three parts: Part 1: Fundamental Aspects; Part 2: Bioadhesive Formulations; Part 3: Drug Delivery Applications. The topics covered include: Theories and mechanisms of bioadhesion; bioadhesive polymers for drug delivery applications; methods for characterization of bioadhesiveness of drug delivery systems; bioadhesive films and drug delivery applications; bioadhesive nanoparticles; and bioadhesive hydrogels and applications ocular biodhesive drug delivery systems; buccal bioadhesive drug delivery systems; gastrointestinal bioadhesive drug delivery systems ; nasal bioadhesive drug delivery systems; vaginal drug delivery systems; pulmonary bioadhesive drug delivery systems.

Author : Vitaliy V. Khutoryanskiy
Publisher : MDPI
Page : 206 pages
File Size : 32,16 MB
Release : 2020-04-22
Category : Medical
ISBN : 3039287524

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Mucoadhesive polymers are widely used in the design of dosage forms for transmucosal drug delivery to the eye, respiratory, gastrointestinal and reproductive tracts. These routes of drug administration offer a number of advantages including improved drug bioavailability, reduced frequency of administration, and the avoidance for the use of injections. This book represents a collection of reviews and original research articles in the area of mucoadhesive polymers and dosage forms. It covers the design of mucoadhesive forms from commercially-available water-soluble polymers, their mixture and complexes as well as some materials, whose mucoadhesive properties were enhanced through chemical modification. With contributions from leading experts in mucoadhesive polymers and formulations, this book will be a very useful source of information for researchers in polymer, pharmaceutical and formulation sciences.

Author : K. L. Mittal
Publisher : John Wiley & Sons
Page : 432 pages
File Size : 50,38 MB
Release : 2020-05-26
Category : Technology & Engineering
ISBN : 1119640261

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This important and unique book comprises 12 chapters divided into three parts examining the fundamental aspects, bioadhesive formulations, and drug delivery applications. Understanding the phenomenon of bioadhesion i.e. its theories or mechanism(s) are of critical importance in developing optimum bioadhesive polymers (used in bioadhesives). Such bioadhesive polymers are the key for exhibiting the process of bioadhesion, controlled/sustained release of drugs, and drug targeting. The use of bioadhesives restricts the delivery system to the site of interest and thus offers a useful and efficient technique for targeting a drug to the desired location for a prolonged duration. This book addresses the various relevant aspects of bioadhesives in drug delivery in an easily accessible and unified manner. The book containing 12 chapters written by eminent researchers from many parts of the globe is divided into three parts: Part 1: Fundamental Aspects; Part 2: Bioadhesive Formulations; Part 3: Drug Delivery Applications. The topics covered include: Theories and mechanisms of bioadhesion; bioadhesive polymers for drug delivery applications; methods for characterization of bioadhesiveness of drug delivery systems; bioadhesive films and drug delivery applications; bioadhesive nanoparticles; bioadhesive hydrogels and applications; ocular biodhesive drug delivery systems; buccal bioadhesive drug delivery systems; gastrointestinal bioadhesive drug delivery systems; nasal bioadhesive drug delivery systems; vaginal drug delivery systems; pulmonary bioadhesive drug delivery systems.

Author : Vivek Dave
Publisher : John Wiley & Sons
Page : 467 pages
File Size : 11,52 MB
Release : 2020-12-29
Category : Computers
ISBN : 1119711681

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The book provides a single volume covering detailed descriptions about various delivery systems, their principles and how these are put in use for the treatment of multiple diseases. It is divided into four sections where the first section deals with the introduction and importance of novel drug delivery system. The second section deals with the most advanced drug delivery systems like microbubbles, dendrimers, lipid-based nanoparticles, nanofibers, microemulsions etc., describing the major principles and techniques of the preparations of the drug delivery systems. The third section elaborates on the treatments of diverse diseases like cancer, topical diseases, tuberculosis etc. The fourth and final section provides a brief informative description about the regulatory aspects of novel drug delivery system that is followed in various countries.

Author : Jinke Xu
Publisher :
Page : pages
File Size : 17,3 MB
Release : 2015
Category :
ISBN :

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"A controlled drug delivery system can deliver a drug with the right dose, control its release rate and time, and target the site of action in the body. Chitosan (CS) and its derivatives have been extensively used in drug delivery. Additionally, CS is mildly mucoadhesive, i.e. it can stick to mucus. Many drug delivery routes such as oral, buccal, and rectal delivery exploit the presence of a mucosa to deliver the drug. Drug delivery systems made from mucoadhesive materials can stick to the mucosa, thus prolonging the retention of drugs on site and allowing a sustained release of the loaded drugs. CS-based mucoadhesive drug delivery systems have shown improved therapeutic effects in many applications.Recently, the strong adhesion of marine mussels under the sea inspired the development of several water-resistant adhesives. The catechol groups present in large amount in the mussel adhesive proteins contribute to the outstanding adhesion of mussels on many different surfaces. Catechols also interact with biological surfaces, including mucus. These findings inspired us to use catechol-CS mucoadhesive systems to facilitate drug delivery. This was the first time that catechol groups were used to improve the mucoadhesion and thus the efficacy of a drug delivery system.In this work, we developed three types of catechol-containing CS hydrogels as mucoadhesive drug delivery systems for oral, buccal and rectal drug delivery. We introduced catechols into CS hydrogels by simple physical mixing or covalent conjugation. We assessed the efficacy of catechol-containing hydrogels as drug delivery systems and their mucoadhesion both in vitro and in vivo.Our first study showed that simple physical mixing of hydrocaffeic acid in CS-based hydrogels enhanced the mucoadhesion of the gels. The electrostatic interaction between hydrocaffeic acid and CS caused a slow release of this molecule from the CS hydrogel, and enhanced the adhesion of CS on mucus. The mucoadhesion of this hydrogel can be further increased in the presence of oxidizing agents during the contact with mucin. However, if the gel is oxidized before contacting mucin, there is no mucoadhesion enhancement. In our second study we developed a chemically conjugated catechol-CS (Cat-CS) hydrogel crosslinked by genipin. In this case, the immobilized catechols were not released from the gel. This system showed good mechanical properties and great mucoadhesion both in vitro and in vivo. Using this mucoadhesive hydrogel, we succeeded in delivering lidocaine to rabbits through the buccal mucosa. Differently from gels made with unmodified CS, this system established an intimate contact with the rabbit buccal mucosa, achieved a sustained release of the drug, and maintained the drug concentration in the blood at a relatively high level during the 2 h experiment.In our third study we developed an injectable sulfasalazine (SSZ) loaded Cat-CS hydrogel formulation for rectal treatment of ulcerative colitis (UC). In UC mice, rectal SSZ/Cat-CS formulation showed better therapeutic effects with only 50% of the normal oral dose. Most importantly, this formulation reduced the plasma levels of the SSZ metabolite sulfapyridine, which is associated with many side effects of SSZ and toxicity. Thus, these results proved the great potential of mucoadhesive SSZ/Cat-CS rectal formulation in UC treatment. Overall, we developed mussel-inspired catechol-containing CS hydrogels that improved the mucoadhesion and thus the drug efficacy and therapeutic effects in drug delivery." --

Author : Kamal Dua
Publisher : Academic Press
Page : 620 pages
File Size : 10,86 MB
Release : 2020-08-04
Category : Technology & Engineering
ISBN : 0128208880

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Targeting Chronic Inflammatory Lung Diseases Using Advanced Drug Delivery Systems explores the development of novel therapeutics and diagnostics to improve pulmonary disease management, looking down to the nanoscale level for an efficient system of targeting and managing respiratory disease. The book examines numerous nanoparticle-based drug systems such as nanocrystals, dendrimers, polymeric micelles, protein-based, carbon nanotube, and liposomes that can offer advantages over traditional drug delivery systems. Starting with a brief introduction on different types of nanoparticles in respiratory disease conditions, the book then focuses on current trends in disease pathology that use different in vitro and in vivo models. The comprehensive resource is designed for those new to the field and to specialized scientists and researchers involved in pulmonary research and drug development. Explores recent perspectives and challenges regarding the management and diagnosis of chronic respiratory diseases Provides insights into how advanced drug delivery systems can be effectively formulated and delivered for the management of various pulmonary diseases Includes the most recent information on diagnostic methods and treatment strategies using controlled drug delivery systems (including nanotechnology)

Author : Ali Demir Sezer
Publisher : BoD – Books on Demand
Page : 516 pages
File Size : 34,77 MB
Release : 2012-10-31
Category : Medical
ISBN : 9535108107

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This contribution book collects reviews and original articles from eminent experts working in the interdisciplinary arena of novel drug delivery systems and their uses. From their direct and recent experience, the readers can achieve a wide vision on the new and ongoing potentialities of different drug delivery systems. Since the advent of analytical techniques and capabilities to measure particle sizes in nanometer ranges, there has been tremendous interest in the use of nanoparticles for more efficient methods of drug delivery. On the other hand, this reference discusses advances in the design, optimization, and adaptation of gene delivery systems for the treatment of cancer, cardiovascular, pulmonary, genetic, and infectious diseases, and considers assessment and review procedures involved in the development of gene-based pharmaceuticals.