[PDF] Monoclonal Antibodies And Peptide Therapy In Autoimmune Diseases eBook

Author : Jean-François Bach
Publisher : Marcel Dekker
Page : 424 pages
File Size : 29,69 MB
Release : 1993
Category : Medical
ISBN :

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Combining principles of modern immunology with applications to immunopathology, this reference documents developments in the immunotherapy of autoimmune diseases - emphasizing monoclonal antibody and peptide approaches. receptor itself to intervening at the level of the major histocompatibility complex (MHC) antigens, Monoclonal Antibodies and Peptide Therapy in Autoimmune Diseases: provides an update on T-cell basic science; discusses most monoclonal antibodies used in autoimmune disease experiments; describes the concept of peptide therapy in its various forms; and presents fundamental pharmacological data that clarify the clinical usage of these new agents. Therapy in Autoimmune Diseases should be a useful resource for immunologists, rheumatologists, pharmacologists, pathologists, dermatologists, nephrologists, and graduate and medical school students in these disciplines.

Author : Kresina
Publisher : CRC Press
Page : 536 pages
File Size : 25,54 MB
Release : 2020-08-26
Category : Medical
ISBN : 1000104206

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Presents a sampling of new and novel approaches to the amelioration of musculoskeletal disease pathology, emphasizing prevention and therapy. Where applicable, these new technologies are focused on their application to human autoimmune diseases, but the volume mainly discusses and details the use of

Author : Vibeke Strand
Publisher : CRC Press
Page : 341 pages
File Size : 33,90 MB
Release : 1996-09-19
Category : Medical
ISBN : 1482273535

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Provides a detailed survey of therapies for autoimmune diseases, exploring the rationale for their use and clinical data regarding their potential benefit.

Author : C. Garrison Fathman
Publisher : Karger Medical and Scientific Publishers
Page : 229 pages
File Size : 37,6 MB
Release : 2000-01-01
Category : Medical
ISBN : 3805569491

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The clinical management of autoimmune diseases has proven to be extremely difficult. Current therapies focus on trying to alleviate symptoms, but fail to correct the fundamental immune defects that lead to pathology. To achieve this goal, it is necessary to understand much of the biology of antigen presentation, lymphocyte activation and the effects of cytokines. The articles in this book provide an up-to-date review of current innovative therapies using both biologic and gene therapy for the treatment of selected autoimmune diseases. Therapeutical approaches discussed include oral tolerance, the use of anti-CD4 monoclonal antibodies, IL-10 and anti-TNFa antibodies, DNA vaccination, and gene therapy applied to organ-specific autoimmune disease. Although some of these techniques are still in their infancy, their potential efficacy has been demonstrated in several animal models of autoimmune disease, holding great promise for the future development of treatments. Written by recognized experts in the field, the chapters in this book illustrate the concept of technology transfer from bench to bedside and provide a valuable update for clinicians and scientists in clinical immunology.

Author : Barton Haynes
Publisher : Elsevier
Page : 337 pages
File Size : 45,34 MB
Release : 2012-12-02
Category : Medical
ISBN : 032315543X

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Monoclonal Antibodies: Probes for the Study of Autoimmunity and Immunodeficiency focuses on the research/studies using monoclonal antibodies in two major classes of diseases, which are autoimmunity and immunodeficiency. The book comprises of 14 chapters; each is written in detail and includes studies using monoclonal antibodies of the pathogenesis and treatment of various types of diseases of disordered immunity. The first chapter presents an overview of the use of monoclonal antibodies in the study of autoimmunity and immunodeficiency. The following chapters focus on other monoclonal reagents and their uses and applications to different diseases. The last four chapters discuss specific classic endocrine diseases in reference to discoveries regarding the beginning of autoimmune mechanisms and pathophysiology. Because the book is technically written, students with background in biology, microbiology, and biochemistry are most likely the target audience of this book. Other parties in the fields of immunology, clinical medicine, pathology, and physiology will also find this book a good reference material.

Author : J. F. Bach
Publisher : Academic Press
Page : 231 pages
File Size : 34,69 MB
Release : 2014-06-28
Category : Medical
ISBN : 1483282260

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Immunointervention in Autoimmune Diseases is a collection of papers presented at the 1988 International Meeting by the same title, held in Paris, France. This text contains 21 chapters and begins with surveys of the role of antigen in autoimmune responses and the moving boundaries between physiology and pathology of immunity. The succeeding chapters deal with the regulation, immunosuppressive therapy, infections, and immunointervention of autoimmune disorders. These topics are followed by discussions of specific immunosuppressive therapy for a particular disease, including type I diabetes, T-cell leukemia, and systemic lupus erythomatosus. This work also explores the principles of allograft, the use of monoclonal antibody, and OKT3. The remaining chapters consider the maintenance of autoimmunity and the risk/benefit in immunointervention for autoimmune diseases. This book will prove useful to immunologists, pathologists, physiologists, and researchers.

Author : Paul Imbach
Publisher : Springer
Page : 361 pages
File Size : 20,96 MB
Release : 2018-03-29
Category : Medical
ISBN : 3319680382

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This practical manual, written by well-known experts, reviews current indications for the use of IgG concentrates and some other modern immunomodulators and provides fundamental information on present-day immunomodulation in patients (and mice). The book opens by tracing the transition from IgG substitution to IgG immunomodulation and providing expert updates on immunomodulatory indications in autoimmune and inflammatory disorders, including hematologic, neurologic, dermatologic, and other diseases. Basic aspects of IgG concentrates, including methods of production, safety, currently available products, and mechanisms of action, are then discussed. An entire chapter is devoted to the different aspects of immunomodulatory IgG treatment in the bleeding disorder immune thrombocytopenia (ITP). Finally, the transition from polyclonal to monoclonal antibody (mAb) treatment is addressed in detail, covering mAb development, methods, mechanisms of action, adverse effects, and more. Particular attention is paid to the example of anti-CD20 (B-cell) antibody.

Author : George S. Eisenbarth
Publisher : CRC Press
Page : 235 pages
File Size : 44,72 MB
Release : 2019-08-08
Category : Medical
ISBN : 1351081896

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Effective immunotherapies The next generation of immunotherapeutic agents

Author : George S. Eisenbarth
Publisher : CRC Press
Page : 240 pages
File Size : 17,87 MB
Release : 1989-09-30
Category : Medical
ISBN : 9780849345586

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This important text will be the first devoted to a detailed analysis of immunotherapy as it ap-plies to Type I diabetes and the pathogenesis and therapy of other specific autoimmune diseases (including uveitis, multiple sclerosis, myasthenia gravis, Cogan's syndrome, Graves' ophthalmopathy, and gonadal disorders).