[PDF] Molecular Mechanisms Of Cellular Stress Responses In Cancer And Their Therapeutic Implications eBook

Author : Megan Chircop
Publisher : Frontiers Media SA
Page : 160 pages
File Size : 38,51 MB
Release : 2015-03-06
Category : Carcinogenesis
ISBN : 2889194965

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In response to stress, cells can activate a myriad of signalling pathways to bring about a specific cellular outcome, including cell cycle arrest, DNA repair, senescence and apoptosis. This response is pivotal for tumour suppression as all of these outcomes result in restriction of the growth and/or elimination of damaged and pre-malignant cells. Thus, a large number of anti-cancer agents target specific components of stress response signalling pathways with the aim of causing tumour regression by stimulating cell death. However, the efficacy of these agents is often impaired due to mutations in genes that are involved in these stress-responsive signalling pathways and instead the oncogenic potential of a cell is increased leading to the initiation and/or progression of tumourigenesis. Moreover, these genetic defects can increase or contribute to resistance to chemotherapeutic agents and/or radiotherapy. Modulating the outcome of cellular stress responses towards cell death in tumour cells without affecting surrounding normal cells is thus one of the ultimate aims in the development of new cancer therapeutics. To achieve this aim, a detailed understanding of cellular stress response pathways and their aberrations in cancer is required. This Research topic aims to reflect the broadness and complexity of this important area of cancer research.

Author : Georg T. Wondrak
Publisher : Springer
Page : 450 pages
File Size : 15,51 MB
Release : 2014-11-07
Category : Medical
ISBN : 9401794219

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It is now established that dysregulated cell stress response pathways play a critical role in tumorigenesis, and a refined mechanistic understanding of this phenomenon at the molecular level promises to open new avenues for targeted therapeutic strategies that may benefit cancer patients in the near future. Coauthored by recognized leaders in cancer research from five continents, this novel book provides a comprehensive perspective on cell stress response pathways and therapeutic opportunities. Focusing on the role of genotoxic, proteotoxic, oxidative, metabolic, and inflammatory stress in tumorigenesis, the book is essential reading for students, basic researchers, and biomedical health care professionals interested in cancer and therapeutic development.

Author : Kondo Takashi Shimizu Tadamichi
Publisher :
Page : 218 pages
File Size : 50,15 MB
Release : 2014-05-14
Category : Medical
ISBN : 9781628089219

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Not all that cannot be seized is an illusion! Many effective powers in nature cannot be seized, including magnetism, electricity and sound. However, they contribute to shaping the quality of human life on a daily basis, transcending health and disease as they interact with the human body. Magnetism is important for stability on earth; however, exposure of the body to magnetic fields is not inert. Such exposure has been reported to alter hormone secretion and stimulate bone formation in vivo. Its coupling with electricity provides light and heat to our planet at certain wavelengths. Yet, the infiltration of shorter or longer wavelengths can be disastrous. For instance, ultraviolet radiation can cause inflammatory skin reactions and carcinogenesis at certain levels. In addition, ionizing radiation is claimed to be the driving force for the origin of power resources on earth, while human exposure to radiation is related to the world's most devastating events. On the other hand, sound, which is a mechanical wave, has been reported to affect cells at inaudible levels, causing alterations in the gene expression and cell death. All these energies as such are identified to exert physical stresses in a biological milieu especially when thresholds of exposure are exceeded. But still "hard times" have significance! Researchers have been accumulating knowledge on the biological effects of these physical stressors and their underlying mechanisms on the molecular and genetic levels, that over years they were able to achieve control over these physical stressors for the benefit of human kind. Nowadays, we see most of these energies employed in diagnosis such as magnetic resonance imaging (MRI) and ultrasound as well as in therapeutics. In our rigorous war against cancer, numerous patients have been cured from tumors by physical means such as ionizing radiation, heating (RF and MW hyperthermia or ablation) or high intensity focused ultrasound (HIFU). Through the chapters of this book, the readers will get introduced to such physical stressors and their biological effects. Recent findings on molecular mechanisms will be thoroughly presented. In addition, perspectives on the modulation of these energies to achieve further therapeutic advantages will be discussed.

Author : Bharat B. Aggarwal
Publisher : Springer
Page : 489 pages
File Size : 48,70 MB
Release : 2014-05-12
Category : Medical
ISBN : 3034808372

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This volume examines in detail the role of chronic inflammatory processes in the development of several types of cancer. Leading experts describe the latest results of molecular and cellular research on infection, cancer-related inflammation and tumorigenesis. Further, the clinical significance of these findings in preventing cancer progression and approaches to treating the diseases are discussed. Individual chapters cover cancer of the lung, colon, breast, brain, head and neck, pancreas, prostate, bladder, kidney, liver, cervix and skin as well as gastric cancer, sarcoma, lymphoma, leukemia and multiple myeloma.

Author : Constantinos Koumenis
Publisher : Springer Science & Business Media
Page : 293 pages
File Size : 49,18 MB
Release : 2013-11-23
Category : Medical
ISBN : 146145915X

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The collection of chapters in this proceeding volume reflects the latest research presented at the Aegean meeting on Tumor Microenvironment and Cellular Stress held in Crete in Fall of 2012. The book provides critical insight to how the tumor microenvironment affects tumor metabolism, cell stemness, cell viability, genomic instability and more. Additional topics include identifying common pathways that are potential candidates for therapeutic intervention, which will stimulate collaboration between groups that are more focused on elucidation of biochemical aspects of stress biology and groups that study the pathophysiological aspects of stress pathways or engaged in drug discovery.

Author : Tadamichi Shimizu
Publisher : Nova Science Publishers
Page : 0 pages
File Size : 11,74 MB
Release : 2013
Category : Biological control systems
ISBN : 9781628089189

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Not all that cannot be seized is an illusion Many effective powers in nature cannot be seized, including magnetism, electricity and sound. However, they contribute to shaping the quality of human life on a daily basis, transcending health and disease as they interact with the human body. Magnetism is important for stability on earth; however, exposure of the body to magnetic fields is not inert. Such exposure has been reported to alter hormone secretion and stimulate bone formation in vivo. Its coupling with electricity provides light and heat to our planet at certain wavelengths. Yet, the infiltration of shorter or longer wavelengths can be disastrous. For instance, ultraviolet radiation can cause inflammatory skin reactions and carcinogenesis at certain levels. In addition, ionising radiation is claimed to be the driving force for the origin of power resources on earth, while human exposure to radiation is related to the worlds most devastating events. On the other hand, sound, which is a mechanical wave, has been reported to affect cells at inaudible levels, causing alterations in the gene expression and cell death.All these energies as such are identified to exert physical stresses in a biological milieu especially when thresholds of exposure are exceeded. But still hard times have significance Researchers have been accumulating knowledge on the biological effects of these physical stressors and their underlying mechanisms on the molecular and genetic levels, that over years they were able to achieve control over these physical stressors for the benefit of human kind. Nowadays, we see most of these energies employed in diagnosis such as magnetic resonance imaging (MRI) and ultrasound as well as in therapeutics. In our rigorous war against cancer, numerous patients have been cured from tumours by physical means such as ionising radiation, heating (RF and MW hyperthermia or ablation) or high intensity focused ultrasound (HIFU). Through the chapters of this book, the readers will get introduced to such physical stressors and their biological effects. Recent findings on molecular mechanisms will be thoroughly presented. In addition, perspectives on the modulation of these energies to achieve further therapeutic advantages will be discussed.

Author : Georg F. Weber
Publisher : Springer
Page : 486 pages
File Size : 39,72 MB
Release : 2015-07-22
Category : Medical
ISBN : 3319132784

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Molecular Therapies of Cancer comprehensively covers the molecular mechanisms of anti-cancer drug actions in a comparably systematic fashion. While there is currently available a great deal of literature on anti-cancer drugs, books on the subject are often concoctions of invited review articles superficially connected to one another. There is a lack of comprehensive and systematic text on the topic of molecular therapies in cancer. A further deficit in the relevant literature is a progressive sub-specialization that typically limits textbooks on cancer drugs to cover either pharmacology or medicinal chemistry or signal transduction, rather than explaining molecular drug actions across all those areas; Molecular Therapies of Cancer fills this void. The book is divided into five sections: 1. Molecular Targeting of Cancer Cells; 2. Emerging and Alternative Treatment Modalities; 3. Molecular Targeting of Tumor-Host Interactions; 4. Anti-Cancer Drug Pharmacokinetics; and 5. Supportive Therapies.

Author : Jordi Camps
Publisher : Springer
Page : 223 pages
File Size : 13,93 MB
Release : 2014-07-19
Category : Medical
ISBN : 3319073206

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Oxidative stress and inflammation underpin most diseases; their mechanisms are inextricably linked. For example, chronic inflammation is associated with oxidation, anti-inflammatory cascades are linked to decreased oxidation, increased oxidative stress triggers inflammation and redox balance inhibits the inflammatory cellular response. Whether or not oxidative stress and inflammation represent the causes or the consequences of cellular pathology, they contribute significantly to the pathogenesis of non-communicable diseases. The incidence of obesity and other related metabolic disturbances are rising, as are age-related diseases due to progressively aging populations. Interrelations between the mechanisms of oxidative stress and of inflammatory signaling and metabolism are, in the broad sense of energy transformation, being increasingly recognized as part of the problem in non-communicable diseases. The book Oxidative Stress and Inflammation in Non-communicable Diseases: Molecular Mechanisms and Perspectives in Therapeutics is an update on the latest research on the molecular basis of non-communicable diseases and the search for possible therapeutic alternatives. The authors of this monograph are experts in their field and the book as a whole, provides an overview of the biochemical alterations underlying diseases such as cardiovascular disease, cancer, obesity, renal disease, neurological diseases and diabetes, emphasizing those aspects that they share in common. We hope that this book will be useful for researchers in biomedicine and also for physicians interested in finding the root causes of the disease, as well as for post-graduate students in biochemistry, molecular biology, nutrition or medicine.

Author : Robert C. Bast, Jr.
Publisher : John Wiley & Sons
Page : 2004 pages
File Size : 50,96 MB
Release : 2017-03-10
Category : Medical
ISBN : 111900084X

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Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates

Author : Stuart K. Calderwood
Publisher : Springer Science & Business Media
Page : 399 pages
File Size : 21,85 MB
Release : 2007-09-09
Category : Medical
ISBN : 1402064012

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Heat shock proteins are emerging as important molecules in the development of cancer and as key targets in cancer therapy. These proteins enhance the growth of cancer cells and protect tumors from treatments such as drugs or surgery. However, new drugs have recently been developed particularly those targeting heat shock protein 90. As heat shock protein 90 functions to stabilize many of the oncogenes and growth promoting proteins in cancer cells, such drugs have broad specificity in many types of cancer cell and offer the possibility of evading the development of resistance through point mutation or use of compensatory pathways. Heat shock proteins have a further property that makes them tempting targets in cancer immunotherapy. These proteins have the ability to induce an inflammatory response when released in tumors and to carry tumor antigens to antigen presenting cells. They have thus become important components of anticancer vaccines. Overall, heat shock proteins are important new targets in molecular cancer therapy and can be approached in a number of contrasting approaches to therapy.