[PDF] Molecular Imaging Of The Brain eBook

Author : M. M. Kaila
Publisher : Springer Science & Business Media
Page : 430 pages
File Size : 42,16 MB
Release : 2012-09-20
Category : Technology & Engineering
ISBN : 3642303013

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This book examines multi-quantum magnetic resonance imaging methods and the diagnostics of brain disorders. It consists of two Parts. The part I is initially devoted towards the basic concepts of the conventional single quantum MRI techniques. It is supplemented by the basic knowledge required to understand multi-quantum MRI. Practical illustrations are included both on recent developments in conventional MRI and the MQ-MRI. This is to illustrate the connection between theoretical concepts and their scope in the clinical applications. The Part II initially sets out the basic details about quadrupole charge distribution present in certain nuclei and their importance about the functions they perform in our brain. Some simplified final mathematical expressions are included to illustrate facts about the basic concepts of the quantum level interactions between magnetic dipole and the electric quadrupole behavior of useful nuclei present in the brain. Selected practical illustrations, from research and clinical practices are included to illustrate the newly emerging ideas and techniques. The reader should note that the two parts of the book are written with no interdependence. One can read them quite independently.

Author : Najam Arfeen Sharif
Publisher : IRL Press
Page : 276 pages
File Size : 16,62 MB
Release : 1993
Category : Medical
ISBN :

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This book reflects the recent dramatic advances in the use of modern imaging techniques to visualize and quantify the various components of cell structure and cell functional activity in the nervous system. Readers will find detailed protocols for imaging neurotransmitter and receptor mRNAs using radioactive and non-radioactive in situ hybridization technology. Methods for visualizing transmitter and drug receptors using quantitative autoradiography, sequence-specific antibodies, and immunocytochemistry are also clearly described. Plus, the book covers the imaging of biological activity in living cells, including methods of monitoring intracellular pH and calcium mobilization using selective ion-sensitive dyes in conjunction with flow cytometry and video microscopy. This is an essential guide for researchers wanting to exploit these powerful new techniques for their studies in neuropharmacology, neuroanatomy, neurogenetics, neuropathology, and pharmaceutical research. receptors, and receptor function in the nervous system. They represent the state of the art for studying brain function and dysfunction in the laboratory. It will be of major interest to neuroscientists and pharmacologists.

Author : Jie Tian
Publisher : Springer Science & Business Media
Page : 707 pages
File Size : 40,6 MB
Release : 2013-07-23
Category : Science
ISBN : 3642343031

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"Molecular Imaging: Fundamentals and Applications" is a comprehensive monograph which describes not only the theory of the underlying algorithms and key technologies but also introduces a prototype system and its applications, bringing together theory, technology and applications. By explaining the basic concepts and principles of molecular imaging, imaging techniques, as well as research and applications in detail, the book provides both detailed theoretical background information and technical methods for researchers working in medical imaging and the life sciences. Clinical doctors and graduate students will also benefit from this book. Jie Tian is a professor at the Institute of Automation, Chinese Academy of Sciences, China.

Author : Agata Elżbieta Wiśniowska
Publisher :
Page : 77 pages
File Size : 39,92 MB
Release : 2019
Category :
ISBN :

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An intricate interplay of signaling molecules underlies brain activity, yet studying these molecular events in living whole organisms remains a challenge. Magnetic resonance imaging (MRI) is the most promising imaging modality for development of molecular signaling sensors with deeper tissue penetration than optical imaging, and better spatial resolution and more dynamic potential in sensor design, compared to radioactive probes. MRI molecular sensors, however, have largely required micromolar concentrations to achieve detectable signals. In order to detect signaling molecules in the brain at their native low nanomolar concentrations, an improvement in MRI molecular sensors is necessary. Here we introduce a new in vivo imaging paradigm that uses vasoactive probes (vasoprobes) that couple molecular signals to vascular responses. We apply the vasoprobes to detect molecular targets at nanomolar concentrations in living rodent brains, thus satisfying the sensitivity requirement for imaging endogenous signaling events. Even with more sensitive probes, molecular imaging of the brain is further complicated by the presence of the blood-brain barrier (BBB), designed by nature to protect this most vital of organs. We have therefore implemented a means to permit noninvasive delivery of imaging agents following ultrasonic BBB opening. We use the ultrasound technique to deliver another potent class of contrast agents, superparamagnetic iron oxides, and we show that effective permeation of brain tissue is achieved using this approach. We have also designed ultrasensitive vasoprobe variants designed to permeate the brain completely noninvasively, using endogenous transporter-mediated mechanisms. We present preliminary results based on this approach and discuss future directions.

Author : Henry N. Wagner
Publisher : Springer Science & Business Media
Page : 397 pages
File Size : 28,55 MB
Release : 2009-01-29
Category : Medical
ISBN : 1848003080

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This book describes what molecular imaging is, how it developed, what are its basic principles, and what it has told us and can tell us about the chemistry of the human brain. Everyone today is conscious of the fact that there is chemistry going on in the brain, and that it is affected by widely used pharmaceuticals and illicit drugs. This book will elucidate these topics in an interesting, historical and philosophical way. The book is a valuable reference resource for all those in nuclear medicine and radiology as well the educated general public.

Author : Brian D. Ross
Publisher : Academic Press
Page : 1872 pages
File Size : 21,5 MB
Release : 2021-08-03
Category : Science
ISBN : 0128163879

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The detection and measurement of the dynamic regulation and interactions of cells and proteins within the living cell are critical to the understanding of cellular biology and pathophysiology. The multidisciplinary field of molecular imaging of living subjects continues to expand with dramatic advances in chemistry, molecular biology, therapeutics, engineering, medical physics and biomedical applications. Molecular Imaging: Principles and Practice, Volumes 1 and 2, Second Edition provides the first point of entry for physicians, scientists, and practitioners. This authoritative reference book provides a comprehensible overview along with in-depth presentation of molecular imaging concepts, technologies and applications making it the foremost source for both established and new investigators, collaborators, students and anyone interested in this exciting and important field. The most authoritative and comprehensive resource available in the molecular-imaging field, written by over 170 of the leading scientists from around the world who have evaluated and summarized the most important methods, principles, technologies and data Concepts illustrated with over 600 color figures and molecular-imaging examples Chapters/topics include, artificial intelligence and machine learning, use of online social media, virtual and augmented reality, optogenetics, FDA regulatory process of imaging agents and devices, emerging instrumentation, MR elastography, MR fingerprinting, operational radiation safety, multiscale imaging and uses in drug development This edition is packed with innovative science, including theranostics, light sheet fluorescence microscopy, (LSFM), mass spectrometry imaging, combining in vitro and in vivo diagnostics, Raman imaging, along with molecular and functional imaging applications Valuable applications of molecular imaging in pediatrics, oncology, autoimmune, cardiovascular and CNS diseases are also presented This resource helps integrate diverse multidisciplinary concepts associated with molecular imaging to provide readers with an improved understanding of current and future applications

Author : Wolfhard Semmler
Publisher : Springer Science & Business Media
Page : 298 pages
File Size : 33,94 MB
Release : 2008-07-15
Category : Medical
ISBN : 3540727183

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The aim of this textbook of molecular imaging is to provide an up to date review of this rapidly growing field and to discuss basic methodological aspects necessary for the interpretation of experimental and clinical results. Emphasis is placed on the interplay of imaging technology and probe development, since the physical properties of the imaging approach need to be closely linked with the biologic application of the probe (i.e. nanoparticles and microbubbles). Various chemical strategies are discussed and related to the biologic applications. Reporter-gene imaging is being addressed not only in experimental protocols, but also first clinical applications are discussed. Finally, strategies of imaging to characterize apoptosis and angiogenesis are described and discussed in the context of possible clinical translation.

Author : Hossein Jadvar
Publisher : Cambridge University Press
Page : 93 pages
File Size : 45,65 MB
Release : 2017-11-16
Category : Medical
ISBN : 1107621283

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Trace the history, and advances in the field of molecular imaging, with this guide to the visual world of disease.

Author : Jie Lu
Publisher : Springer Nature
Page : 396 pages
File Size : 40,55 MB
Release : 2023-05-29
Category : Medical
ISBN : 9811999023

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This book aims to summarize the research progress of integrated PET/MR brain function and molecular imaging, and more importantly, clinical application and research status of PET/MR of brain imaging from brain diseases to brain science. Starting from the overviews of brain function imaging technology, following chapters introduces clinical application of integrated PET/MR specific brain diseases in details, such as Alzheimer's disease, Parkinson's disease, epilepsy, and brain tumor, etc., which are hot issues of brain science research. It will be a useful reference to residents and practitioners in nuclear medicine, radiology, and neurology, as well as those interested in molecular imaging of brain.

Author : Ralph Weissleder
Publisher : PMPH-USA
Page : 1384 pages
File Size : 11,38 MB
Release : 2010
Category : Diagnostic imaging
ISBN : 9781607950059

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The field of molecular imaging of living subjects have evolved considerably and have seen spectacular advances in chemistry, engineering and biomedical applications. This textbook was designed to fill the need for an authoritative source for this multi-disciplinary field. We have been fortunate to recruit over 80 leading authors contributing 75 individual chapters. Given the multidisciplinary nature of the field, the book is broken into six different sections: "Molecular Imaging technologies", "Chemistry", "Molecular Imaging in Cell and Molecular Biology", "Applications of Molecular Imaging", "Molecular Imaging in Drug Evaluation" with the final section comprised of chapters on computation, bioinformatics and modeling. The organization of this large amount of information is logical and strives to avoid redundancies among chapters. It encourages the use of figures to illustrate concepts and to provide numerous molecular imaging examples.