[PDF] Modifications To International Center eBook

Author : United States. Congress. Senate. Committee on Foreign Relations. Subcommittee on International Complex
Publisher :
Page : 126 pages
File Size : 30,8 MB
Release : 1966
Category : Acquisition of foreign publications
ISBN :

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Considers S. 2710, to authorize the Federal purchase or lease of property in D.C. for use as headquarters site for OAS and as sites for foreign embassies.

Author : Ivan Mijakovic
Publisher : Frontiers Media SA
Page : 206 pages
File Size : 39,31 MB
Release : 2015-07-22
Category : Microbiology
ISBN : 2889196100

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Post-translational modifications (PTMs) are widely employed by all living organisms to control the enzymatic activity, localization or stability of proteins on a much shorter time scale than the transcriptional control. In eukarya, global analyses consistently reveal that proteins are very extensively phosphorylated, acetylated and ubiquitylated. Glycosylation and methylation are also very common, and myriad other PTMs, most with a proven regulatory potential, are being discovered continuously. The emergent picture is that PTM sites on a single protein are not independent; modification of one residue often affects (positively or negatively) modification of other sites on the same protein. The best example of this complex behavior is the histone “bar-code” with very extensive cross-talk between phosphorylation, acetylation and methylation sites. Traditionally it was believed that large networks of PTMs exist only in complex eukaryal cells, which exploit them for coordination and fine-tuning of various cellular functions. PTMs have also been detected in bacteria, but the early examples focused on a few important regulatory events, based mainly on protein phosphorylation. The global importance (and abundance) of PTMs in bacterial physiology was systematically underestimated. In recent years, global studies have reported large datasets of phosphorylated, acetylated and glycosylated proteins in bacteria. Other modifications of bacterial proteins have been recently described: pupylation, methylation, sirtuin acetylation, lipidation, carboxylation and bacillithiolation. As the landscape of PTMs in bacterial cells is rapidly expanding, primarily due to advances of detection methods in mass spectrometry, our research field is adapting to comprehend the potential impact of these modifications on the cellular physiology. The field of protein phosphorylation, especially of the Ser/Thr/Tyr type, has been profoundly transformed. We have become aware that bacterial kinases phosphorylate many protein substrates and thus constitute regulatory nodes with potential for signal integration. They also engage in cross-talk and eukaryal-like mutual activation cascades. The regulatory potential of protein acetylation and glycosylation in bacteria is also rapidly emerging, and the cross-talk between acetylation and phosphorylation has been documented. This topic deals with the complexity of the PTM landscape in bacteria, and focus in particular on the physiological roles that PTMs play and methods to study them. The topic is associated to the 1st International Conference on Post-Translational Modifications in Bacteria (September 9-10, 2014, Göttingen, Germany).

Author : Anna M. Doro-on
Publisher : CRC Press
Page : 817 pages
File Size : 37,70 MB
Release : 2022-09-27
Category : Political Science
ISBN : 1498758258

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This book provides multifaceted components and full practical perspectives of systems engineering and risk management in security and defense operations with a focus on infrastructure and manpower control systems, missile design, space technology, satellites, intercontinental ballistic missiles, and space security. While there are many existing selections of systems engineering and risk management textbooks, there is no existing work that connects systems engineering and risk management concepts to solidify its usability in the entire security and defense actions. With this book Dr. Anna M. Doro-on rectifies the current imbalance. She provides a comprehensive overview of systems engineering and risk management before moving to deeper practical engineering principles integrated with newly developed concepts and examples based on industry and government methodologies. The chapters also cover related points including design principles for defeating and deactivating improvised explosive devices and land mines and security measures against kinds of threats. The book is designed for systems engineers in practice, political risk professionals, managers, policy makers, engineers in other engineering fields, scientists, decision makers in industry and government and to serve as a reference work in systems engineering and risk management courses with focus on security and defense operations.

Author : Colin Carter
Publisher : Emerald Group Publishing
Page : 409 pages
File Size : 27,5 MB
Release : 2011-07-25
Category : Business & Economics
ISBN : 0857247573

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This volume brings together fresh insights from top agricultural economists in the areas of consumer attitudes, environmental impacts, policy and regulation, trade, investment, food security, and development, in an attempt to provide a new perspective on the most pressing policy questions facing GM technology.