[PDF] Model Selection Techniques For Locatingquantitative Trait Loci eBook

Author : Andreas Baierl
Publisher : Sudwestdeutscher Verlag Fur Hochschulschriften AG
Page : 96 pages
File Size : 35,70 MB
Release : 2008
Category :
ISBN : 9783838101224

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Recent technological advances in genetics pose new challenging problems to statistical methodology. The genetic technique of QTL mapping deals with locating genes that influence a quantitative character of an organism. Within the statistical framework of model selection, existing approaches are adapted and modifed: The search for genetic effects is extended to interactions between genes (i.e. epistatsis), while taking computational performance into account. Robust statistical methods are included in order to cope with quantitative effects that have heavy-tailed distribution or outliers. The performance and applicability of all methods is assessed by extensive simulation studies and the reanalysis of previously published genetic data sets.

Author : Nicola J. Camp
Publisher : Springer Science & Business Media
Page : 362 pages
File Size : 18,21 MB
Release : 2008-02-03
Category : Medical
ISBN : 1592591760

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In Quantitative Trait Loci: Methods and Protocols, a panel of highly experienced statistical geneticists demonstrate in a step-by-step fashion how to successfully analyze quantitative trait data using a variety of methods and software for the detection and fine mapping of quantitative trait loci (QTL). Writing for the nonmathematician, these experts guide the investigator from the design stage of a project onwards, providing detailed explanations of how best to proceed with each specific analysis, to find and use appropriate software, and to interpret results. Worked examples, citations to key papers, and variations in method ease the way to understanding and successful studies. Among the cutting-edge techniques presented are QTDT methods, variance components methods, and the Markov Chain Monte Carlo method for joint linkage and segregation analysis.

Author : Joel Ira Weller
Publisher : CABI
Page : 288 pages
File Size : 23,68 MB
Release : 2009
Category : Technology & Engineering
ISBN : 1845937341

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Quantitative Trait Loci (QTL) is a topic of major agricultural significance for efficient livestock production. This book covers various statistical methods that have been used or proposed for detection and analysis of QTL and marker-and gene-assisted selection in animal genetics and breeding.

Author : Florian Frommlet
Publisher : Springer
Page : 290 pages
File Size : 28,10 MB
Release : 2016-01-06
Category : Computers
ISBN : 9781447153115

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This book presents the methodology of association mapping in experimental populations and genome-wide association studies (GWAS). The main emphasis is placed on methods based on modifications of the Bayesian information criterion, designed specifically to handle multiple testing problems in large-scale genome scans for trait loci (TL). The book is written at the level of a graduate course for bioinformatics students. The first chapter introduces the major concepts of quantitative trait loci (QTL) mapping. The second chapter discusses the methodology of QTL mapping in experimental populations, with the main emphasis on the related issues of model selection in linear models. The approach is then extended to TL via generalized linear models. Chapter three describes the methods for GWAS and related multiple testing and model selection problems. In both chapters two and three the properties of QTL mapping methods are illustrated with computer simulations and real data analysis.

Author : Scott A. Rifkin
Publisher : Humana Press
Page : 331 pages
File Size : 37,40 MB
Release : 2012-05-09
Category : Medical
ISBN : 9781617797866

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Over the last two decades advances in genotyping technology, and the development of quantitative genetic analytical techniques have made it possible to dissect complex traits and link quantitative variation in traits to allelic variation on chromosomes or quantitative trait loci (QTLs). In Quantitative Trait Loci (QTLs):Methods and Protocols, expert researchers in the field detail methods and techniques that focus on specific components of the entire process of quantitative train loci experiments. These include methods and techniques for the mapping populations, identifying quantitative trait loci, extending the power of quantitative trait locus analysis, and case studies. Written in the highly successful Methods in Molecular BiologyTM series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory. Thorough and intuitive, Quantitative Trait Loci (QTLs):Methods and Protocols aids scientists in the further study of the links between phenotypic and genotypic variation in fields from medicine to agriculture, from molecular biology to evolution to ecology.

Author : Jagath C.- Rajapakse
Publisher : Springer
Page : 427 pages
File Size : 16,14 MB
Release : 2007-09-19
Category : Science
ISBN : 3540752862

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This book constitutes the refereed proceedings of the International Workshop on Pattern Recognition in Bioinformatics, PRIB 2007, held in Singapore in October 2007. The 38 revised full papers presented were carefully reviewed and selected from 125 submissions. The papers discuss the applications of pattern recognition methods in the field of bioinformatics to solve problems in life sciences.

Author : Michael Lynch
Publisher : Sinauer Associates Incorporated
Page : 980 pages
File Size : 31,59 MB
Release : 1998-01
Category : Science
ISBN : 9780878934812

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Professors Lynch and Walsh bring together the diverse array of theoretical and empirical applications of quantitative genetics in a work that is comprehensive and accessible to anyone with a rudimentary understanding of statistics and genetics.