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Author : Jaime M. Ross
Publisher : MDPI
Page : 543 pages
File Size : 46,32 MB
Release : 2018-09-28
Category : Science
ISBN : 3038422517
This book is a printed edition of the Special Issue "Mitochondrial Dysfunction in Ageing and Diseases" that was published in IJMS
Author : Richard H. Haas
Publisher : MDPI
Page : 268 pages
File Size : 29,45 MB
Release : 2019-10-01
Category : Science
ISBN : 303921327X
This collection of review articles authored by international experts pulls together current information about the role of mitochondria in aging and diseases of aging. Mitochondria are vitally important cellular organelles and undergo their own aging process becoming less efficient in aged animals including humans. These changes have wide-ranging significance contributing to immune dysfunction (autoimmunity and immune deficiency), inflammation, delayed healing, skin and retinal damage, cancer and most of the degenerative diseases of aging. Mitochondrial aging predisposes to drug toxicity in the geriatric population and to many of the features of normal aging. The research detailed in this book summarizes current understanding of the role of mitochondria in the complex molecular changes of aging, moving on to specific diseases of aging. Mitochondrial dysfunction is an important target for development of treatments for aging and disease. The last article details how exercise is a treatment and combats many features of the aging process.
Author : Lawrence H. Lash
Publisher : Elsevier
Page : 527 pages
File Size : 26,23 MB
Release : 2013-10-22
Category : Science
ISBN : 1483218619
Methods in Toxicology, Volume 2: Mitochondrial Dysfunction provides a source of methods, techniques, and experimental approaches for studying the role of abnormal mitochondrial function in cell injury. The book discusses the methods for the preparation and basic functional assessment of mitochondria from liver, kidney, muscle, and brain; the methods for assessing mitochondrial dysfunction in vivo and in intact organs; and the structural aspects of mitochondrial dysfunction are addressed. The text also describes chemical detoxification and metabolism as well as specific metabolic reactions that are especially important targets or indicators of damage. The methods for measurement of alterations in fatty acid and phospholipid metabolism and for the analysis and manipulation of oxidative injury and antioxidant systems are also considered. The book further tackles additional methods on mitochondrial energetics and transport processes; approaches for assessing impaired function of mitochondria; and genetic and developmental aspects of mitochondrial disease and toxicology. The text also looks into mitochondrial DNA synthesis, covalent binding to mitochondrial DNA, DNA repair, and mitochondrial dysfunction in the context of developing individuals and cellular differentiation. Microbiologists, toxicologists, biochemists, and molecular pharmacologists will find the book invaluable.
Author :
Publisher : Academic Press
Page : 300 pages
File Size : 44,38 MB
Release : 2014-08-19
Category : Science
ISBN : 0123948401
Mitochondria, the "power plants" of eukaryotic cells, are best known for the generation of adenosine triphosphate (ATP), the universal cellular "energy currency" of the cell, and the synthesis of different essential components. Mitochondrial dysfunction is known to lead to various degenerative disorders, disease, and aging. The Mitochondrion in Aging and Disease works to unravel the processes leading to mitochondrial impairments and of pathways involved in mitochondrial quality control and their impact on health and aging will be addressed. Reviews current topics of interest Written by experts in the field
Author :
Publisher :
Page : 516 pages
File Size : 31,78 MB
Release : 2016
Category : Electronic books
ISBN : 9783038422525
Mitochondrial Dysfunction in Ageing and Diseases.
Author : Richard H. Haas
Publisher :
Page : 1 pages
File Size : 27,29 MB
Release : 2019
Category : Electronic books
ISBN : 9783039213283
This collection of review articles authored by international experts pulls together current information about the role of mitochondria in aging and diseases of aging. Mitochondria are vitally important cellular organelles and undergo their own aging process becoming less efficient in aged animals including humans. These changes have wide-ranging significance contributing to immune dysfunction (autoimmunity and immune deficiency), inflammation, delayed healing, skin and retinal damage, cancer and most of the degenerative diseases of aging. Mitochondrial aging predisposes to drug toxicity in the geriatric population and to many of the features of normal aging. The research detailed in this book summarizes current understanding of the role of mitochondria in the complex molecular changes of aging, moving on to specific diseases of aging. Mitochondrial dysfunction is an important target for development of treatments for aging and disease. The last article details how exercise is a treatment and combats many features of the aging process.
Author : Marcos Roberto de Oliveira
Publisher : Academic Press
Page : 602 pages
File Size : 27,89 MB
Release : 2021-07-15
Category : Science
ISBN : 0323886183
Mitochondrial Dysfunction and Nanotherapeutics: Aging, Diseases, and Nanotechnology-Related Strategies in Mitochondrial Medicine provides a comprehensive overview of mitochondrial dysfunction and current strategies for targeting the organelle. Based on the most current research, the editor lined up a team of worldwide experts to cover the most exciting research in the area, considering the impact through the human life span. This book is structured in two parts that provide a good balance of foundational and applied content. Part I deals with an overview of mitochondrial dysfunction and its role in the aging process, including metabolic diseases, neuro-affective and neurodegenerative disorders, sepsis, and toxicological aspects. Part II covers therapeutic substance delivery to mitochondria with a focus on cancer, neurodegenerative diseases, and increasing the bioavailability of natural compounds of interest. Several nanoscale strategies are described. Mitochondrial Dysfunction and Nanotherapeutics: Aging, Diseases, and Nanotechnology-Related Strategies in Mitochondrial Medicine is a complete resource for researchers in this exciting field. Its comprehensive coverage makes this book particularly interesting to bioscience researchers looking to understand the foundations of mitochondrial health throughout the human life span. Additionally, clinician researchers, medical doctors, nutritionists, pharmacologists, and sports scientists may be attracted to the detailed information on the organelle-targeted delivery strategies. Contains detailed information on mitochondrial dysfunction Reviews our current understanding of the role of mitochondria in aging Includes coverage of specific conditions, including sports and affective disorders, among others Discusses mitochondria targeted delivery of therapeutic compounds
Author : Stephen Bondy
Publisher : Springer Science & Business Media
Page : 468 pages
File Size : 31,9 MB
Release : 2010-09-02
Category : Medical
ISBN : 1607616025
Features that characterize the aging process include the gradual accumulation of cell damage after prolonged exposure to oxidative and inflammatory events over a lifetime. In addition to the accretion of lesions, the intrinsic levels of pro-oxidant and aberrant immune responses are elevated with age. These adverse events are often further enhanced by the chronic and slow progressing diseases that characterize the senescent brain and cardiovascular system. The incidence of some disorders such as Alzheimer's disease and vascular diseases are sufficiently prevalent in the extreme elderly that these disorders can arguably be considered "normal". Aging and Aging-Related Disorders examines the interface between normal and pathological aging, and illustrates how this border can sometimes be diffuse. It explores and illustrates the processes underlying the means by which aging becomes increasingly associated with inappropriate levels of free radical activity and how this can serve as a platform for the progression of age-related diseases. The book provides chapters that examine the interactive relationship between systems in the body that can enhance or sometimes even limit cellular longevity. In addition, specific redox mechanisms in cells are discussed. Another important aspect for aging discussed here is the close relationship between the systems of the body and exposure to environmental influences of oxidative stress that can affect both cellular senescence and a cell’s nuclear DNA. What may be even more interesting to note is that these external stressors are not simply confined to illnesses usually associated with aging, but can be evident in maturing and young individuals. A broad range of internationally recognized experts have contributed to this book. Their aim is to successfully highlight emerging knowledge and therapy for the understanding of the basis and development of aging–related disorders.
Author : Sabzali Javadov
Publisher :
Page : 434 pages
File Size : 35,40 MB
Release : 2020-09-04
Category :
ISBN : 9783039363841
Mitochondria are subcellular organelles evolved by the endosymbiosis of bacteria with eukaryotic cells. They are the main source of ATP in the cell and engaged in other aspects of cell metabolism and cell function, including the regulation of ion homeostasis, cell growth, redox status, and cell signaling. Due to their central role in cell life and death, mitochondria are also involved in the pathogenesis and progression of human diseases/conditions, including neurodegenerative and cardiovascular disorders, cancer, diabetes, inflammation, and aging. However, despite the increasing number of studies, precise mechanisms whereby mitochondria are involved in the regulation of basic physiological functions, as well as their role in the cell under pathophysiological conditions, remain unknown. A lack of in-depth knowledge of the regulatory mechanisms of mitochondrial metabolism and function, as well as interplay between the factors that transform the organelle from its role in pro-survival to pro-death, have hindered the development of new mitochondria-targeted pharmacological and conditional approaches for the treatment of human diseases. This book highlights the latest achievements in elucidating the role of mitochondria under physiological conditions, in various cell/animal models of human diseases, and in patients.
Author : John Binnington
Publisher : Foster Academics
Page : 0 pages
File Size : 39,58 MB
Release : 2023-09-26
Category : Medical
ISBN : 9781646465590
Mitochondria are double-membrane-bound organelles found in eukaryotic cells. They build cable-like structures and deliver energy to cells with the help of oxidative phosphorylation (OXPHOS) process. Aging causes a wide range of interrelated conditions and is also a leading cause of various human diseases. The age-associated changes in mitochondria are linked with deterioration in mitochondrial function. The accumulation of oxidative damage and mutations caused by reactive oxygen species (ROS), mitochondrial functionality, and DNA volume and integrity decline with age. Mitochondrial dysfunction includes an increase in oxidative damage and a reduction in oxidative capacity, and plays a significant role in biological aging. The accumulation of dysfunctional mitochondria occurs in all the tissues with aging, including brain, liver and skeletal muscle. These dysfunctional mitochondria are marked and removed through an autophagic process named mitophagy. Mitochondrial dysfunction occurs in many neurodegenerative diseases such as Huntington's disease (HD), amyotrophic lateral sclerosis (ALS), Parkinson's disease (PD), Friedreich's ataxia (FRDA) and Alzheimer's disease (AD). This book explores all the important aspects of mitochondrial dysfunction and its impact on aging and diseases. Experts and students actively engaged in researches on mitochondrial dysfunction will find it full of crucial and unexplored concepts.