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Transport of molecules across the cell membrane is a fundamental process of all living organisms. It is essential for understanding growth, development, nutrition as well as uptake and excretion of exogenous or synthesized molecules. Microbes respresent general and basic functional systems where many transport processes have been studied on a molecular basis. Knowledge of the microbial transport processes will provide new perspectives to treatments by inhibitors, drugs, antibiotics, vitamins, growth promotion compounds, activators and toxic compunds of various kinds.
Transport of molecules across the cell membrane is a fundamental process of all living organisms. It is essential for understanding growth, development, nutrition as well as uptake and excretion of exogenous or synthesized molecules. Microbes respresent general and basic functional systems where many transport processes have been studied on a molecular basis. Knowledge of the microbial transport processes will provide new perspectives to treatments by inhibitors, drugs, antibiotics, vitamins, growth promotion compounds, activators and toxic compunds of various kinds.
Much of the information currently available on the transport systems of bacterial and animal cell membranes and their mode of coupling to metabolic supply of energy can be found in this volume. Consideration of the participating enzymes dictated the choice of topics: Several transport systems where little information is available on the enzymology of the process are not included, while separate chapters deal with y-glutamyl transpeptidase and intestinal disaccharidases which meet many of the requirements of transport enzymes. The volume also includes two chapters on photosynthetic membranes as a general introduction to the topic. Other aspects of biological transport and photosynthesis will be developed in detail in a forthcoming volume now in preparation. These chapters reveal the excitement and rapid advance of the field, the daily reports of new concepts, new techniques, and new experimental findings which instantly interact to generate further progress. Our aim was to provide a starting point for those who are just beginning, and an opportunity for others to stop, take stock, and start in a new direction. My warmest thanks to all who contributed to this volume.
Mechanisms and Regulation of Carbohydrate Transport in Bacteria reviews the developments in the study of the mechanisms and regulation of carbohydrate transport in prokaryotic organisms. The book presents the progress made in the understanding of transport and regulation of carbohydrates in bacteria in the molecular level. Aspects on the important structural and topographical features of several sugar permeases in Escherichia coli are elucidated; the energy-coupling processes are clearly delineated for most (but not all) types of bacterial carbohydrate permease systems; and mechanistic details ...
Microbiology has undergone a number of metamorphoses in its relatively brief existence. It has been in approximate succession, morphology, epidemiology, biochemistry, genetics, and molecular biology. It is also becoming a significant parcel of cell surface studies. The one embodiment which has remained elusiv- particularly for bacteriology - is the taxonomic one. This may have been a blessing in disguise because it encouraged microbiologists to deal with the general rather than the particular; promoting a search for unitary explanations, in the manner of Kluyver and van Niel, long before anyone knew about the universality of the genetic code, or could trace the genealogy of enzymes from the study of amino acid substitutions. . This volume is predicated on the idea that deep analogies underly the mech anisms of cellular interaction, and therefore belongs in the unitary tradition of microbiology. It occupies itself with a wide variety of micro-organisms, considering them from vantage points of considerable diversity, ranging from taxonomic irreverence to keen evolutionary awareness, and is concerned with areas which have developed independently of each other.
With the growing realization that microbial transport proteins exhibit homologies to various degrees not only among themselves, but also to membrane proteins of eukaryotic cells, this book represents a timely review of the current state of knowledge and research.
Protein transport into and across membranes is a fundamental process in bacteria that touches upon and unites many areas of microbiology, including bacterial cell physiology, adhesion and motility, nutrient scavenging, intrabacterial signaling and social behavior, toxin deployment, interbacterial antagonism and collaboration, host invasion and disruption, and immune evasion. A broad repertoire of mechanisms and macromolecular machines are required to deliver protein substrates across bacterial cell membranes for intended effects. Some machines are common to most, if not all bacteria, whereas others are specific to Gram-negative or Gram-positive species or species with unique cell envelope properties such as members of Actinobacteria and Spirochetes. Protein Secretion in Bacteria, authored and edited by an international team of experts, draws together the many distinct functions and mechanisms involved in protein translocation in one concise tome. This comprehensive book presents updated information on all aspects of bacterial protein secretion encompassing: Individual secretory systems–Sec, Tat, and T1SS through the newly discovered T9SS Mechanisms, structures, and functions of bacterial secretion systems Lipoprotein sorting pathways, outer membrane vesicles, and the sortase system Structures and roles of surface organelles, including flagella, pili, and curli Emerging technologies and translational implications Protein Secretion in Bacteria serves as both an introductory guide for students and postdocs and a ready reference for seasoned researchers whose work touches on protein export and secretion. This volume synthesizes the diversity of mechanisms of bacterial secretion across the microbial world into a digestible resource to stimulate new research, inspire continued identification and characterization of novel systems, and bring about new ways to manipulate these systems for biotechnological, preventative, and therapeutic applications.