[PDF] Metals In Health Set eBook

Author : Gaspar Banfalvi
Publisher : Springer Science & Business Media
Page : 348 pages
File Size : 36,18 MB
Release : 2011-03-02
Category : Medical
ISBN : 9400704283

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The term “heavy metals” is used as a group name of toxic metals and metalloids (semimetals) causing contaminations and ecotoxicity. In strict chemical sense the density of heavy metals is higher than 5 g/cm3. From biological point of view as microelements they can be divided into two major groups. a. For their physiological function organisms and cells require essential microelements such as iron, chromium (III), cobalt, copper, manganese, molidenium, zinc. b. The other group of heavy metals is toxic to the health or environment. Of highest concern are the emissions of As, Cd, Co, Cu, Hg, Mn, Ni, Pb, Sn, Tl. The toxicity of heavy metals is well known at organizational level, while less attention has been paid to their cellular effects. This book describes the toxicity of heavy metals on microorganisms, yeast, plant and animal cells. Other chapters of the book deal with their genotoxic, mutagenic and carcinogenic effects. The toxicity of several metals touch upon the aspects of environmental hazard, ecosystems and human health. Among the cellular responses of heavy metals irregularities in cellular mechanisms such as gene expression, protein folding, stress signaling pathways are among the most important ones. The final chapters deal with biosensors and removal of heavy metals. As everybody is eating, drinking and exposed to heavy metals on a daily basis, the spirit of the book will attract a wide audience.

Author : Peggy L. Carver
Publisher : Walter de Gruyter GmbH & Co KG
Page : 455 pages
File Size : 29,96 MB
Release : 2019-01-14
Category : Science
ISBN : 3110527871

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Volume 19, entitled Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic of the series Metal Ions in Life Sciences centers on the role of metal ions in clinical medicine. Metal ions are tightly regulated in human health: while essential to life, they can be toxic as well. Following an introductory chapter briefly discussing several important metal-related drugs and diseases and a chapter about drug development, the focus is fi rst on iron: its essentiality for pathogens and humans as well as its toxicity. Chelation therapy is addressed in the context of thalassemia, its relationship to neurodegenerative diseases and also the risks connected with iron administration are pointed out. A subject of intense debate is the essentiality of chromium and vanadium. For example, chromium(III) compounds are taken as a nutritional supplement by athletes and bodybuilders; in contrast, chromate, Cr(VI), is toxic and a carcinogen for humans. The benefi cial and toxic effects of manganese, cobalt, and copper on humans are discussed. The need for antiparasitic agents is emphasized as well as the clinical aspects of metal-containing antidotes for cyanide poisoning. In addition to the essential and possibly essential ones, also other metal ions play important roles in human health, causing harm (like the metalloid arsenic, lead or cadmium) or being used in diagnosis or treatment of human diseases, like gadolinium, gallium, lithium, gold, silver or platinum. The impact of this vibrant research area on metals in the clinic is provided in 14 stimulating chapters, written by internationally recognized experts from the Americas, Europe and China, and is manifested by approximately 2000 references, and about 90 illustrations and tables. Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic is an essential resource for scientists working in the wide range from pharmacology, enzymology, material sciences, analytical, organic, and inorganic biochemistry all the way through to medicine ... not forgetting that it also provides excellent information for teaching.

Author : Astrid Sigel
Publisher : Springer Science & Business Media
Page : 603 pages
File Size : 18,69 MB
Release : 2014-01-27
Category : Science
ISBN : 9400775008

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MILS-13 provides an up-to-date review on the relationships between essential metals and human diseases, covering 13 metals and 3 metalloids: The bulk metals sodium, potassium, magnesium, and calcium, plus the trace elements manganese, iron, cobalt, copper, zinc, molybdenum, and selenium, all of which are essential for life. Also covered are chromium, vanadium, nickel, silicon, and arsenic, which have been proposed as being essential for humans in the 2nd half of the last century. However, if at all, they are needed only in ultra-trace amounts, and because of their prevalence in the environment, it has been difficult to prove whether or not they are required. In any case, all these elements are toxic in higher concentrations and therefore, transport and cellular concentrations of at least the essential ones, are tightly controlled; hence, their homeostasis and role for life, including deficiency or overload, and their links to illnesses, including cancer and neurological disorders, are thoroughly discussed. Indeed, it is an old wisdom that metals are indispensable for life. Therefore, Volume 13 provides in an authoritative and timely manner in 16 stimulating chapters, written by 29 internationally recognized experts from 7 nations, and supported by more than 2750 references, and over 20 tables and 80 illustrations, many in color, a most up-to-date view on the vibrant research area of the Interrelations between Essential Metal Ions and Human Diseases.

Author : Michael Aschner
Publisher : Springer
Page : 377 pages
File Size : 15,16 MB
Release : 2017-09-09
Category : Medical
ISBN : 331960189X

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Assembles international authorities to address contemporary research in metal neurotoxicity. Essential and non-essential metals play an important role in neurodevelopmental and neurodegenerative diseases. Recent developments in understanding the role of metals in the etiology of these disorders have led to rapid growth in clarifying the pathology of some of the most devastating diseases we face and in identifying potential new therapies. Few books or periodicals have been wholly dedicated to the topic of metals, and this collection is intended to serve as a resource for all researchers interested in metals and their role in health and disease.

Author : J.O. Nriagu
Publisher : Springer Science & Business Media
Page : 446 pages
File Size : 39,28 MB
Release : 2012-12-06
Category : Science
ISBN : 3642693148

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of metal interactions with subcellular biochemical systems usually either are metabolites of the system affected (porphyrinurias) or represent some specific function of a cellular system being impaired (proteinurias). One typically finds a continuum of symptoms, from the subtle or so-called "no effect" bio chemical and physiological indicators of exposure to severe clinical disease and death. This continuum is the basis of much of the controversy since many health officials follow the traditional practice of applying the "threshold health-effect" concept in evaluating the problems of environmental exposure to metals. The past decade or so, however, has seen a vast increase in our understanding of the effects of elevated concentrations of toxic metals in local populations and ecosystems. At the same time, there is a growing awareness that the effects of the metals which occur naturally in the environment must be distinguished from those imposed by the pollutant fraction. This point was amply document ed in a recent study of cadmium intake and cadmium in a number of human tissues in Sweden, Japan, and the United States, which showed fairly conclu sively that the background exposure in Japan was about threefold higher than in the other two countries (2). One immediate implication is that any health ef fect studies of cadmium in Japan using control groups within that country are liable to underestimate the difference between the exposed and the control groups simply because of the the high "background" intake.

Author : Richard H. Guy
Publisher : CRC Press
Page : 440 pages
File Size : 44,5 MB
Release : 1999-04-05
Category : Medical
ISBN : 0824746848

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"Addresses the increase of toxic heavy metals in the environment. Sets the standard for future research in interactions between the skin and metals and metal compounds-covering the general toxicology of 35 metals and metalloids, their occurrence in the environment, significance in nutrition, skin diffusivity, occupational exposure risks, and immunotoxicity."

Author : Lance Castillo
Publisher :
Page : 202 pages
File Size : 19,60 MB
Release : 2016
Category : MEDICAL
ISBN : 9781634856256

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Heavy metals are persistent in the environment and their elevated emission during longer periods of time can cause contamination of the environment. They are emitted in all environmental media, but can also be easily transported between them due to the atmospheric deposition, water runoff, etc., and thus accumulate in the environment or penetrate the food chains. The main routes of human exposure to heavy metals are through ingestion, inhalation or via dermal contact. Hence, there is a need for better understanding of absorption, distribution and deposition of heavy metals in the human body. This information is of a crucial importance for the evaluation of heavy metal potential health implications. In this book, Chapter One provides an overview of the heavy metal health hazards, presented as a consequence of heavy metal pollution, their availability and cycling between different media in the environment. Chapter Two comprehensively discusses the roles and harmful effects of heavy metals on human health, as well as the sources and techniques of removing heavy metals from the environment. Chapter Three explores the mechanisms of mercury cardiovascular toxicity, with a particular emphasis on its effects toward endothelial cells. Chapter Four focuses on the effects of exposure to soil contaminated by metals. Chapter Five examines antimicrobial functionalized textiles. Chapter Six discusses thallium poisoning. Chapter Seven provides a review of heavy metal pollution, human exposure and public health implications in Nigeria.

Author : A. Vercruysse
Publisher : Elsevier
Page : 349 pages
File Size : 44,77 MB
Release : 2000-04-01
Category : Science
ISBN : 0080875521

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Hazardous Metals in Human Toxicology