[PDF] Mechanisms And Models In Rheumatoid Arthritis eBook

Author : B. Henderson
Publisher : Academic Press
Page : 567 pages
File Size : 30,56 MB
Release : 1995-03-16
Category : Medical
ISBN : 0080536026

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Rheumatoid arthritis is a bewilderingly complex disease involving the interactions of many, and varied, cell populations and multiple families of low and high molecular mass mediators. We are only slowly beginning to understand the mechanisms that produce the local and systematic pathology clinically recognized as rheumatoid arthritis. Increasingly, use is being made of experimental models of this disease in an effort to test hypotheses about putative pathological mechanisms and to investigate the effect of novel therapeutic agents. A major section of this book covers these experimental models in great detail from their development through to reviews of the most recent information on each model.Mechanisms and Models in Rheumatoid Arthritis brings together a group of eminent researchers from the fields of clinical rheumatology, pathology, experimental pathology, immunology, connective tissue biochemistry, microbiology, pharmacology and developmental biology to describe the current views of the cellular and humoral mechanisms that drive the pathology of rheumatoid arthritis and experimental models of rheumatoid arthritis. Key Features:* The book is divided into five sections:* The clinical spectrum, aetiopathogenesis, the role of microbial superantigens in pathology and the present and future therapies for rheumatoid arthritis* The pathology of rheumatoid arthritis, the development and role of synovial pannus and the use of immunohistochemistry in defining synovial pathology* Cell populations involved in synovitis with chapters on synovial cells, chondrocytes, bone cells, leukocytes and leukocyte trafficking* Mediators, with coverage of: cytokines and cytokine inhibitors, growth factors, free radicals and inflammatory lipid mediators, neuropeptides and proteases* Current studies on experimental models of rheumatoid arthritis

Author : H. Deicher
Publisher : Springer Science & Business Media
Page : 328 pages
File Size : 16,33 MB
Release : 2012-12-06
Category : Medical
ISBN : 3642681069

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Rheumatoid arthritis is a common disease, an estimated 1. 5% of the population being under medical treatment for it in European countries and elsewhere. However, to date the origin of this chronic inflammatory disorder has not been elucidated. Evidence for the involvement of microbial agents is still tenuous, the rea son for the defective control of inflammation is still unknown, and the disease all too of ten progresses to crippling stages despite long-term treatment. As T. McKeown recently stated with regard to rheumatoid arthritis, "not enough is even known to indicate which is the more promising approach, and the pru dent course is to investigate both origins and mechanisms". While working on animal model diseases as well as on aspects of rheumatoid arthritis and related disorders in man, the members of the Special Research Area on patho physiology of rheumatoid inflammation in man and. animals (Sonderforschungsbereich 54 "Pa thomechanismen der rheumatoiden Entztindung bei Mensch und Tier"; maintained by the Deut sche Forschungsgemeinschaft) at the Veterinary and Medical Schools, Hannover, have been guided by the concept that by studying clinically and morphologically similar diseases in several species, mutually stimulating results might lead to improved knowledge of the pathophysio logy of rheumatoid arthritis. In particular, from working with model diseases in animals new approaches to the etiology of rheumatoid arthritis might be derived, while detailed knowledge of pathogenetic processes in rheu matoid arthritis could further research in chronic stages of pertinent animal diseases

Author : J. J. Goronzy
Publisher : Karger Medical and Scientific Publishers
Page : 290 pages
File Size : 14,43 MB
Release : 2001-01-01
Category : Medical
ISBN : 3805571208

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This book, the third volume of the new series 'Current Directions in Autoimmunity', is the first one to exclusively focus on one disease. Written by experts in genetics and immunobiology, the articles reflect the complexity and multiple facets of the disease process but also show their convergence to a better understanding of pathogenetic mechanisms and the evolving clinical applications. The models and concepts described in this volume have implications for studies of other inflammatory diseases and are of interest not only for clinical and basic scientists devoted to the study of rheumatoid arthritis but for investigators of autoimmune diseases in general.

Author : Reem Hamdy A. Mohammed
Publisher : BoD – Books on Demand
Page : 170 pages
File Size : 41,15 MB
Release : 2020-11-19
Category : Medical
ISBN : 1839625325

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Rheumatoid Arthritis - Other Perspectives towards Better Practice sheds light on the disease process of rheumatoid arthritis as well as the disease’s related comorbidities. Chapters cover such topics as immune-pathogenic theories, classification criteria, available composite measures of disease assessment, and latest available therapeutic approaches.

Author : Paul Emery
Publisher :
Page : 0 pages
File Size : 40,33 MB
Release : 2005
Category : Rheumatoid arthritis
ISBN : 9781416027676

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This issue covers the latest developments in the understanding of rheumatoid arthritis at the early stage. Treatments such as with newer biologic agents and conventional disease-modifying antirheumatic drugs are reviewed. Also included are articles on imaging modalities as a means of identifying those in the early stages and monitoring response to treatment.