[PDF] Measuring Resting Cerebral Perfusion Using Magnetic Resonance Imaging Mri eBook

Author : James Duffin
Publisher : Frontiers Media SA
Page : 170 pages
File Size : 28,97 MB
Release : 2024-07-12
Category : Science
ISBN : 2832550215

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The acquisition of resting cerebral perfusion measures using magnetic resonance imaging (MRI) is one of the assessments of cerebrovascular health used to discern how well patients are coping with anatomical changes such as stenosis, and other factors impacting the supply of blood flow to the brain. Perfusion measures may be obtained using several MRI based techniques including arterial spin labeling (ASL) and dynamic contrast enhanced methods that rely on injected contrast agents such as gadolinium. Recently hypoxia-induced changes in deoxyhemoglobin have been used as a non-invasive contrast agent, measuring the resulting changes in blood oxygen dependent (BOLD) signals with MRI. With each approach, the means through which voxel-wise cerebral perfusion information is derived differs, leading to the development a variety of analysis methods in recent studies. This Research Topic is intended to attract manuscripts that advance the use of resting cerebral perfusion measures in clinical assessments of cerebrovascular health. In pursuit of this aim a better understanding of several aspects are needed.

Author : Nora-Josefin Breutigam
Publisher :
Page : 0 pages
File Size : 46,13 MB
Release : 2022
Category :
ISBN :

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Magnetic resonance imaging (MRI) is a powerful technique that enables accurate medical diagnoses. Not only does it allow the visualization of static tissue contrasts, but it also provides the ability to measure the function and physiology behind important life processes. This dissertation presents two methods for imaging physiological effects, namely diffusion and perfusion. For diffusion-weighted imaging, but not limited to this application, a technique called simultaneous multi-contrast (SMC) imaging is introduced to acquire multiple image contrasts from different scan types within a single measurement. This technique offers new opportunities in clinical protocols where examination time is a critical factor and multiple image contrasts need to be acquired. The method was tested in a phantom and healthy subjects. The results showed that simultaneous acquisition of two contrasts (here diffusion-weighted imaging and T2*-weighting) with SMC imaging is possible with robust contrast separation and minimal impact on image quality. Thereby, the simultaneous acquisition of multiple contrasts reduces the overall examination time and there is inherent registration between contrasts. For cerebral perfusion-weighted imaging, the goal of this work was to increase the robustness of time-encoded arterial spin labeling (ASL) to image artifacts by adjusting the timing of imaging during active scanning individually for each subject. One of the major challenges in ASL imaging is the high variability of arterial transit times (ATT), which leads to arterial transit delay (ATD) artifacts. In particular, in patients with pathologic changes, these artifacts occur when post-labeling delay (PLD) and bolus duration are not optimally matched to the individual, resulting in difficult quantification of cerebral blood flow (CBF) and ATT. This is also true for the free-lunch (FL) approach in Hadamard-encoded pseudocontinuous ASL (H-pCASL). The method was tested in healthy subjects, with FL-bolus timing individualized by the developed and implemented adaptive H-pCASL sequence in combination with an automatic feedback algorithm. Automatic subject-specific adjustment of the FL-bolus PLD during an ongoing measurement may reduce uncertainties in perfusion quantification and reduce the number of cases in which measurements have to be repeated because the recommended timing does not fit the patient.

Author : A. Gregory Sorensen
Publisher : Thieme
Page : 174 pages
File Size : 15,79 MB
Release : 2000
Category : Medical
ISBN : 9780865779259

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This book will familiarize the reader with the basic principles of perfusion MR imaging. Relevant technical aspects, contrast agents, and the postprocessing of images are presented, and imaging protocols are provided. Dedicated software for personal use on the postprocessing of images is provided on a CD-ROM containing hundreds of images and movie clips that demonstrate all concepts. In addition to the technical details of acquisition and postprocessing, numerous examples of the application of these tools in the clinical setting are also shown. In particular, the book includes a discussion of the role of perfusion MRI in the current evaluation of cerebrovascular disease, including an integrative approach using diffusion in conjunction with perfusion imaging. This text covers: all relevant technical aspects of perfusion MR imaging imaging protocols application of these tools in a clinical setting integration of diffusion imaging with perfusion imaging for enhanced diagnostic capabilities Also addressed are the role of perfusion MRI in the assessment of cerebral neoplasia, challenges and opportunities for treatment that tumors present, and the particular strengths of perfusion MRI, such as its relatively high resolution and possible microvascular specificity. For both newcomers and experienced practitioners, this is a nuts-and-bolts description of an important new technique.

Author : Peter B. Barker
Publisher : Cambridge University Press
Page : 373 pages
File Size : 22,81 MB
Release : 2013-05-16
Category : Medical
ISBN : 1107013399

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This concise and comprehensive review uniquely contains all the information required to perform and interpret clinical MR perfusion imaging.

Author : Hai-Ling Margaret Cheng
Publisher : Elsevier
Page : 564 pages
File Size : 21,3 MB
Release : 2023-09-01
Category : Science
ISBN : 0323952100

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Quantitative Perfusion MRI: Techniques, Applications, and Practical Considerations, Volume 11 clearly and carefully explains the basic theory and MRI techniques for quantifying perfusion non-invasively in deep tissue, covering all aspects of perfusion imaging, from acquisition requirements to selection of contrast agents and appropriate pharmacokinetic models and for reliable quantification in different diseases and tissue types. Specifically, this book enables the reader to understand what microvascular functional parameters can be measured with perfusion MRI, learn the basic techniques to measure perfusion in different organs, apply the appropriate perfusion MRI technique to the organ of interest, and much more. This complete reference on quantitative perfusion MRI is highly suitable for both early and experienced researchers, graduate students and clinicians wishing to understand how quantitative perfusion MRI can apply to their application area of interest. Provides a one-stop resource for students and early and experienced researchers on all aspects of quantitative perfusion MRI as written by experts in the field Explains basic theory and MRI techniques Presents a strong focus on the practical considerations that can make or break perfusion MRI Includes applications in oncology, cardiology, neurology and body imaging

Author : Jean Chen
Publisher : Humana
Page : 218 pages
File Size : 35,33 MB
Release : 2021-11-06
Category : Medical
ISBN : 9781071617625

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This volume provides a comprehensive overview of the methodology, physiology, and contemporary and novel applications of cerebrovascular reactivity (CVR) measurements. The chapters in this book cover topics such as an introduction of the neurophysiology, neuroimaging, and clinical methods for CVR measurement; the use of CVR methods in the study of aging, cerebrovascular dysfunction, dementia, and brain tumors; and recommendations for measurement protocols and future applications in clinical translation. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your research center and clinical investigation. Thorough and comprehensive, Cerebrovascular Reactivity: Methodological Advances and Clinical Applications is a valuable tool that provides researchers in neuroscience and neurology with the latest resources on the measurement, interpretation, and application of CVR measurement.

Author : Richard B. Buxton
Publisher : Cambridge University Press
Page : 479 pages
File Size : 18,18 MB
Release : 2009-08-27
Category : Medical
ISBN : 1139481304

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Functional Magnetic Resonance Imaging (fMRI) has become a standard tool for mapping the working brain's activation patterns, both in health and in disease. It is an interdisciplinary field and crosses the borders of neuroscience, psychology, psychiatry, radiology, mathematics, physics and engineering. Developments in techniques, procedures and our understanding of this field are expanding rapidly. In this second edition of Introduction to Functional Magnetic Resonance Imaging, Richard Buxton – a leading authority on fMRI – provides an invaluable guide to how fMRI works, from introducing the basic ideas and principles to the underlying physics and physiology. He covers the relationship between fMRI and other imaging techniques and includes a guide to the statistical analysis of fMRI data. This book will be useful both to the experienced radiographer, and the clinician or researcher with no previous knowledge of the technology.

Author : Michael Chappell
Publisher : Oxford University Press
Page : 157 pages
File Size : 29,2 MB
Release : 2018
Category : Medical
ISBN : 0198793812

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ASL is an increasingly popular tool to study the brain. The aim of this primer is to equip someone new to the field with the knowledge to make informed choices about ASL acquisition and analysis. While providing a stand-alone introduction to this subject, the text can be read with others in the series for a comprehensive overview of neuroimaging.