[PDF] Marine Natural Products Diversity And Biosynthesis eBook

Author : Paul J. Scheuer
Publisher : Springer
Page : 212 pages
File Size : 32,99 MB
Release : 1993-07-23
Category : Science
ISBN :

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1. B.J. Baker, R.G. Kerr: Biosynthesis of Marine Sterols 2. C.W.J. Chang, P.J. Scheuer: Marine Isocyano Compounds 3. G. Cimino, G. Sodano: Biosynthesis of Secondary Metabolites in Marine Molluscs 4. W.H. Gerwick, D.G. Nagle, P.J. Proteau: Oxylipins from Marine Invertebrates

Author : Emiliano Manzo
Publisher :
Page : 148 pages
File Size : 42,33 MB
Release : 2021-11-04
Category :
ISBN : 9783036517681

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Marine natural products are characterized by high chemical diversity, biochemical specificity, and other molecular properties that make them favorable as lead structures for drug discovery. In this field, one of the main problems is often the reduced natural availability of isolated substances, which can complicate both the structural characterization and possible future developments. For these reasons, the study of bioactive marine metabolites should rely on the development of chemical synthesis and synthetic strategies aimed at the preparation of pure compounds and analogs both for structural confirmation and/or for the large-scale preparation necessary for future applications. Moreover, natural products can be a crucial starting point for the preparation of molecules structurally inspired by the latter, opening the path to new classes of biologically active compounds with pharmacological potential. This book collects original research articles regarding synthetic strategies for secondary marine metabolites and/or analogs that favor applications of these molecules and/or solve structural challenges common in the field of natural substances.

Author : Hiromasa Kiyota
Publisher : Springer Nature
Page : 510 pages
File Size : 41,96 MB
Release : 2021-09-02
Category : Science
ISBN : 9811646376

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This book is a compilation of the latest achievements of leading researchers in marine natural products with extremely diverse structures and biological activities. It presents discussions of isolation, structure elucidation, biosynthesis, total synthesis, and biochemical properties of the compounds with characteristic structures such as macrolides, cyclic depsipeptides, alkaloids, and water-soluble heterocyclic low-molecular-weight compounds, from sponges, bacteria, cyanobacteria, flagellates, and other such organisms. The book especially focuses on heterocyclic natural products as a title in the book series, Topics in Heterocyclic Chemistry.

Author : Didier Stien
Publisher : MDPI
Page : 146 pages
File Size : 20,91 MB
Release : 2020-06-17
Category : Science
ISBN : 3039361821

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A trillion different microbial species have been evolving for some 3.5 billion years, producing ever more complex active secondary metabolites. The sea is a cauldron of a great diversity of useful and valuable compounds. This Special Issue focused on studies of marine microbe natural products for discovering compounds useful to humankind. Papers were collected that provide up-to-date information regarding the characterization of marine microbes’ metabolic diversity and the evaluation of the therapeutic potential of marine microbes’ metabolites. Most of the articles in this book deal with marine fungi, biological and chemical diversity, and their active metabolites. This may be a sign that marine fungi have been under studied to date and are perceived by many researchers as an important source of discovery in this field. A best practices guide for the isolation of marine fungi from different matrixes and their conservation is also presented. The comparison of the phylogenetic and metabolomic profiles of microalgae from different lineages provides novel insights into the potential of chemotaxonomy in marine phytoplankton, showing a good overlap of phylogenetic and chemotaxonomic signals.

Author : Paul J. Scheuer
Publisher : Springer
Page : 212 pages
File Size : 35,92 MB
Release : 1993-07-23
Category : Science
ISBN :

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1. B.J. Baker, R.G. Kerr: Biosynthesis of Marine Sterols 2. C.W.J. Chang, P.J. Scheuer: Marine Isocyano Compounds 3. G. Cimino, G. Sodano: Biosynthesis of Secondary Metabolites in Marine Molluscs 4. W.H. Gerwick, D.G. Nagle, P.J. Proteau: Oxylipins from Marine Invertebrates

Author : Anne Osbourn
Publisher : John Wiley & Sons
Page : 601 pages
File Size : 26,31 MB
Release : 2014-04-02
Category : Science
ISBN : 1118794605

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Natural Products: Discourse, Diversity and Design provides an informative and accessible overview of discoveries in the area of natural products in the genomic era, bringing together advances across the kingdoms. As genomics data makes it increasingly clear that the genomes of microbes and plants contain far more genes for natural product synthesis than had been predicted from the numbers of previously identified metabolites, the potential of these organisms to synthesize diverse natural products is likely to be far greater than previously envisaged. Natural Products addresses not only the philosophical questions of the natural role of these metabolites, but also the evolution of single and multiple pathways, and how these pathways and products may be harnessed to aid discovery of new bioactives and modes of action. Edited by recognized leaders in the fields of plant and microbial biology, bioorganic chemistry and natural products chemistry, and with contributions from researchers at top labs around the world, Natural Products is unprecedented in its combination of disciplines and the breadth of its coverage. Natural Produces: Discourse, Diversity and Design will appeal to advanced students and experienced researchers, from academia to industry, in diverse areas including ecology, industrial biotechnology, drug discovery, medicinal chemistry, agronomy, crop improvement, and natural product chemistry.

Author : Ernesto Fattorusso
Publisher : Springer
Page : 1452 pages
File Size : 13,6 MB
Release : 2012-10-23
Category : Science
ISBN : 9789048138562

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"Handbook of Marine Natural Products" takes a fresh approach to describing the major themes of research in this rapidly developing field. This two volume reference work begins with a section that provides a taxonomic survey of the secondary metabolites of diverse marine life including microbes, algae, and invertebrates. This is followed by a demonstration of the techniques and strategies employed in modern structure elucidation of complex natural products. The natural roles of marine natural products are then explored in a series of focused chapters which include the topics of symbiosis, anti-predation and antifouling, chemical interactions, and defence against UV stress. Various routes which facilitate the understanding of marine natural product biosynthesis are subsequently explained and these are followed by an extensive set of chapters on the biomedical potential of marine natural products. The latter portion of this section considers the technologies and scientific disciplines necessary for advancing bioactive marine natural product lead compounds into actual pharmaceuticals. The reference work finishes with a selection of chapters describing marine toxins and their impact on public health and seafood resources. Final thoughts presented at the end of the second volume focus on the future of this field of investigation and discovery research. This publication is presented as a reference handbook and general concepts are emphasized and illustrated with numerous interesting examples, graphical information, and a comprehensive index. "Handbook of Marine Natural Products" introduces students who are at advanced undergraduate and entry graduate student levels to this fascinating multidisciplinary field. It is an ideal desk companion for courses focusing on this contemporary area.