[PDF] Marburg Virus Disease eBook

Author : G. A. Martini
Publisher : Springer Science & Business Media
Page : 237 pages
File Size : 38,46 MB
Release : 2013-11-11
Category : Medical
ISBN : 3662015935

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In the late summer of 1967, several patients suffering from a severe disease were admitted to the Department of Medicine of the Marburg University. It soon became obvious that the illness was a hitherto unknown infectious disease. The number of afflicted patients increased to 23. Several cases were observed in Frankfurt/Main at the same time and, some weeks later also in Belgrade, Yugo slavia. Common to all the patients was previous contact with the blood or tissues of Cercopithecus aethiops, the vervet monkey. Altogether 31 people became ill and 7 died. It was soon apparent that the infectious agent was neither bacterial nor rickettsial in origin but that a viral etiology was probable. Most of the known viral diseases were excluded and the infectious agent was shown to be a hitherto unknown virus with many peculiar characteristics: it infects guinea pigs but not adult mice and is larger than known viruses and of different shape. This agent was called the "Marburg virus" since most of the cases had occurred in Marburg and the greater part of the laboratory work leading to the detection of the virus was performed in Marburg.

Author : World Health Organization
Publisher : World Health Organization
Page : 203 pages
File Size : 13,75 MB
Release : 2016-05-03
Category : Medical
ISBN : 9241549602

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First published in March 2014 under the title "Clinical management of patients with viral haemorrhagic fever: a pocket guide for front-line health workers: interim emergency guidance for West Africa".

Author : Elena Ryabchikova
Publisher :
Page : 242 pages
File Size : 19,90 MB
Release : 2004
Category : Medical
ISBN :

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Electron microscopy has a special place among the wide range of techniques available for viral research. With electron microscopy, a virologist can follow the course of viral infections by visualizing cell damage and viral replication. Each virus family has its own structural and functional attributes, but attention is usually focused on the pathogenic and health-threatening viruses. The Ebola and Marburg filoviruses are notorious among these. The work was done at Vector in Novosibirsk, Russia, by Dr. Ryabchikova. Dr. Price has made it possible for Dr. Ryabchikova to explain her experiments and insights by expanding the descriptions and making the book readable by professionals who are not steeped in the intricacies of virology. In the course of writing this book, Dr. Price has incorporated more complete references of work done by other laboratories so that the story of the filoviruses is a compilation of the research done internationally, but told from the Russian perspective. In Ebola and Marburg Viruses: A View of Infection Using Electron Microscopy, the authors combine recent published and unpublished literature with the insight developed in over 30 years in electron microscopy and 15 years in virology to tell the story of filoviruses and how they invade and conquer their hosts. The book describes the dynamic properties of these viruses, follows the stages of filoviral infection from the individual cell to the whole organism, and reconstructs the sequential events that occur in filoviral infections. The book also demonstrates that, rather than a curiosity, the electron micrograph is an integral tool in studies of viral infection and the pathological process. Ebola and MarburgViruses: A View of Infection Using Electron Microscopy includes over 100 outstanding electron micrographs of filoviruses and the cell and tissue damage they cause during infection. Ebola and Marburg Viruses: A View of Infection Using Electron Microscopy is addressed to investigators in the widely diversified fields of medicine and biology. For this reason, Ryabchikova and Price have carefully elucidated concepts familiar to virologists that may be unfamiliar to nonvirolgists. The book is also designed to provide opportunities for investigators specializing in viruses to correlate their findings with the work of electron microscopists.

Author : Hans-Dieter Klenk
Publisher : Garland Science
Page : 392 pages
File Size : 44,22 MB
Release : 2004
Category : Cell physiology
ISBN : 9780954523237

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The Ebola and Marburg viruses are a pair of filoviruses that are among the most lethal hemorrhagic viruses on the planet. The authors present a review of past and current research into these pathogens, including 12 papers addressing the structure of the viral proteins; genomic replication; molecular mechanisms of entry; pathogenesis in nonhuman primates, guinea pigs, and mice; virus modulation of innate immunity; and cellular and molecular mechanisms of Ebola pathogenicity and related approaches to vaccine development.

Author : Richard Preston
Publisher : Corgi
Page : 383 pages
File Size : 13,21 MB
Release : 1995
Category : Ebola virus disease
ISBN : 9780552143035

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Imagine a killer with the infectiousness of the common cold and power of the Black Death. Imagine something so deadly that it wipes out 90% of those it touches. Imagine an organism against which there is no defence. But you don't need to imagine. Such a killer exists: it is a virus and its name is Ebola. The Hot Zone tells what happens when the unthinkable becomes reality: when a deadly virus, from the rain forests of Africa, crosses continents and infects a monkey house ten miles from the White House. Ebola is that reality. It has the power to decimate the world's population. Try not to panic. It will be back. There is nothing you can do...

Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
Page : 137 pages
File Size : 21,56 MB
Release : 2016-12-30
Category : Medical
ISBN : 0309450063

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The most recent Ebola epidemic that began in late 2013 alerted the entire world to the gaps in infectious disease emergency preparedness and response. The regional outbreak that progressed to a significant public health emergency of international concern (PHEIC) in a matter of months killed 11,310 and infected more than 28,616. While this outbreak bears some unique distinctions to past outbreaks, many characteristics remain the same and contributed to tragic loss of human life and unnecessary expenditure of capital: insufficient knowledge of the disease, its reservoirs, and its transmission; delayed prevention efforts and treatment; poor control of the disease in hospital settings; and inadequate community and international responses. Recognizing the opportunity to learn from the countless lessons of this epidemic, the National Academies of Sciences, Engineering, and Medicine convened a workshop in March 2015 to discuss the challenges to successful outbreak responses at the scientific, clinical, and global health levels. Workshop participants explored the epidemic from multiple perspectives, identified important questions about Ebola that remained unanswered, and sought to apply this understanding to the broad challenges posed by Ebola and other emerging pathogens, to prevent the international community from being taken by surprise once again in the face of these threats. This publication summarizes the presentations and discussions from the workshop.

Author : Jens Kuhn
Publisher : Springer Science & Business Media
Page : 410 pages
File Size : 48,90 MB
Release : 2008-05-29
Category : Medical
ISBN : 3211694951

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This is the first comprehensive review of the world literature on filovirus research and provides the most extensive bibliography of the subject yet published. There is special emphasis on foreign literature that has never been summarized. Every aspect of filovirus research, including their history, epidemiology, clinical picture, pathology, molecular biology, and political aspects are reviewed in detail.

Author : Tino F. Schwarz
Publisher : Springer Science & Business Media
Page : 201 pages
File Size : 22,48 MB
Release : 2012-12-06
Category : Medical
ISBN : 3709174821

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This book deals both with the epidemiologic background and the specific characteristics of vector-borne and emerging viral infections which may be spread all over the world due to today’s rapid transport of infected individuals or animal vectors. Detailed description of the situation with e.g. Dengue, Japanese encephalitis, Lassa, hepatitis, HIV and filoviruses helps to plan diagnostic approaches and to develop scenarios for the handling of patients suspected of carrying high hazard viruses.

Author : Theodore H. Tulchinsky
Publisher : Academic Press
Page : 911 pages
File Size : 21,89 MB
Release : 2014-03-26
Category : Medical
ISBN : 012415767X

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The New Public Health has established itself as a solid textbook throughout the world. Translated into 7 languages, this work distinguishes itself from other public health textbooks, which are either highly locally oriented or, if international, lack the specificity of local issues relevant to students' understanding of applied public health in their own setting. This 3e provides a unified approach to public health appropriate for all masters' level students and practitioners—specifically for courses in MPH programs, community health and preventive medicine programs, community health education programs, and community health nursing programs, as well as programs for other medical professionals such as pharmacy, physiotherapy, and other public health courses. Changes in infectious and chronic disease epidemiology including vaccines, health promotion, human resources for health and health technology Lessons from H1N1, pandemic threats, disease eradication, nutritional health Trends of health systems and reforms and consequences of current economic crisis for health Public health law, ethics, scientific d health technology advances and assessment Global Health environment, Millennium Development Goals and international NGOs

Author : Institute of Medicine
Publisher : National Academies Press
Page : 310 pages
File Size : 15,45 MB
Release : 2015-03-19
Category : Medical
ISBN : 0309314003

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In the past half century, deadly disease outbreaks caused by novel viruses of animal origin - Nipah virus in Malaysia, Hendra virus in Australia, Hantavirus in the United States, Ebola virus in Africa, along with HIV (human immunodeficiency virus), several influenza subtypes, and the SARS (sudden acute respiratory syndrome) and MERS (Middle East respiratory syndrome) coronaviruses - have underscored the urgency of understanding factors influencing viral disease emergence and spread. Emerging Viral Diseases is the summary of a public workshop hosted in March 2014 to examine factors driving the appearance, establishment, and spread of emerging, re-emerging and novel viral diseases; the global health and economic impacts of recently emerging and novel viral diseases in humans; and the scientific and policy approaches to improving domestic and international capacity to detect and respond to global outbreaks of infectious disease. This report is a record of the presentations and discussion of the event.