[PDF] Low Level Light Detection eBook

Author : Claus Grupen
Publisher : Springer Science & Business Media
Page : 1251 pages
File Size : 35,45 MB
Release : 2011-10-29
Category : Science
ISBN : 3642132707

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The handbook centers on detection techniques in the field of particle physics, medical imaging and related subjects. It is structured into three parts. The first one is dealing with basic ideas of particle detectors, followed by applications of these devices in high energy physics and other fields. In the last part the large field of medical imaging using similar detection techniques is described. The different chapters of the book are written by world experts in their field. Clear instructions on the detection techniques and principles in terms of relevant operation parameters for scientists and graduate students are given.Detailed tables and diagrams will make this a very useful handbook for the application of these techniques in many different fields like physics, medicine, biology and other areas of natural science.

Author : Habib Zaidi
Publisher : Springer
Page : 762 pages
File Size : 30,72 MB
Release : 2014-05-27
Category : Medical
ISBN : 1493908944

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This book examines the fundamental concepts of multimodality small-animal molecular imaging technologies and their numerous applications in biomedical research. Driven primarily by the widespread availability of various small-animal models of human diseases replicating accurately biological and biochemical processes in vivo, this is a relatively new yet rapidly expanding field that has excellent potential to become a powerful tool in biomedical research and drug development. In addition to being a powerful clinical tool, a number of imaging modalities including but not limited to CT, MRI, SPECT and PET are also used in small laboratory animal research to visualize and track certain molecular processes associated with diseases such as cancer, heart disease and neurological disorders in living small animal models of disease. In vivo small-animal imaging is playing a pivotal role in the scientific research paradigm enabling to understand human molecular biology and pathophysiology using, for instance, genetically engineered mice with spontaneous diseases that closely mimic human diseases.

Author :
Publisher : Elsevier
Page : 768 pages
File Size : 31,98 MB
Release : 2000-05-12
Category : Science
ISBN : 0080496644

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Since the publication of Bioluminescence and Chemiluminescence, Part B, genes have been cloned that encode luciferases from an array of bioluminescent organisms, novel applications of these genes have been developed, and much has been learned of the fundamental chemistry, biochemistry, structural biology, and biophysics of these intriguing enzymes. New strategies for application of chemiluminescence technology have been developed and refined, promising to further reduce the need to use radioisotopes in basic research and clinical laboratory settings. Methods for detection of low levels of light continue to push the limits of detection, allowing ready monitoring in real time of intricate subcellular processes within living cells. This book affords a glimpse of the state of the art of a rapidly advancing field, and presents to users of these methods a detailed reference of current activities in the field.The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences. Outlines the use of luminescent reporter technologies to monitor gene expression and protein trafficking Describes the luminescence-based clinical assay technologies Details the basic biochemistry, biophysics, and chemistry of light-emitting reactions that are critical for applications Includes explanations of the instrumentation used for detection and quantification of low level light Shows the new applications of luminescence-based technologies that result largely from broad advances in recombinant DNA technologies and nonscale methods

Author : M.A. Trishenkov
Publisher : Springer Science & Business Media
Page : 481 pages
File Size : 41,16 MB
Release : 2012-12-06
Category : Science
ISBN : 9401512906

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This book is addressed to designers of photodetectors and photodetecting systems, designers of focal plane arrays, charge-coupled devices, specialists in IR technologies, designers of optoelectronic detecting, guiding and tracking systems, systems for IR direction finders, lidars, lightwave communication systems, IR imagers. All these specialists are united by one common purpose: they are all striving to catch the weakest possible optical signal. The most important characteristic of photosensitive devices is their detectivity, which determines the lowest level of optical signal they are able to detect above the noise level. These threshold characteristics define the most important tactical and technical parameters of the entire optoelectronic system, such as its range, resolution, precision. The threshold characteristics of optoelectronic system depend on many of its components; all designers agree, however, that the critically responsible part of the system is the photodetector [1]. By the end of the 1960s the physicists and the engineers were able to overcome many obstacles and to create photodetectors (at least single-element or few-element ones) which covered all the main optical bands (0. 4 . . . 2,2 . . . 3, 3 . . . 5,8 . . . 14 J. . Lm), carried out the detection almost without any loss (the quantum yield being as high as 0. 7 . . . 0. 9), and reduced the noise level to the lowest possible limit.

Author : Nader Rifai
Publisher : Elsevier Health Sciences
Page : 1888 pages
File Size : 39,90 MB
Release : 2017-01-16
Category : Medical
ISBN : 0323548482

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The Tietz Textbook of Clinical Chemistry and Molecular Diagnostics, 6th Edition provides the most current and authoritative guidance on selecting, performing, and evaluating the results of new and established laboratory tests. This classic clinical chemistry reference offers encyclopedic coverage detailing everything you need to know, including: analytical criteria for the medical usefulness of laboratory tests, variables that affect tests and results, laboratory medicine, applications of statistical methods, and most importantly clinical utility and interpretation of laboratory tests. It is THE definitive reference in clinical chemistry and molecular diagnostics, now fully searchable and with quarterly content updates, podcasts, clinical cases, animations, and extended content online through Expert Consult. Analytical criteria focus on the medical usefulness of laboratory procedures. Reference ranges show new approaches for establishing these ranges — and provide the latest information on this topic. Lab management and costs gives students and chemists the practical information they need to assess costs, allowing them to do their job more efficiently and effectively. Statistical methods coverage provides you with information critical to the practice of clinical chemistry. Internationally recognized chapter authors are considered among the best in their field. Two-color design highlights important features, illustrations, and content to help you find information easier and faster. NEW! Internationally recognized chapter authors are considered among the best in their field. NEW! Expert Consult features fully searchable text, quarterly content updates, clinical case studies, animations, podcasts, atlases, biochemical calculations, multiple-choice questions, links to Medline, an image collection, and audio interviews. You will now enjoy an online version making utility of this book even greater. UPDATED! Expanded Molecular Diagnostics section with 12 chapters that focus on emerging issues and techniques in the rapidly evolving and important field of molecular diagnostics and genetics ensures this text is on the cutting edge and of the most value. NEW! Comprehensive list of Reference Intervals for children and adults with graphic displays developed using contemporary instrumentation. NEW! Standard and international units of measure make this text appropriate for any user — anywhere in the world. NEW! 22 new chapters that focus on applications of mass spectrometry, hematology, transfusion medicine, microbiology, biobanking, biomarker utility in the pharmaceutical industry and more! NEW! Expert senior editors, Nader Rifai, Carl Wittwer and Rita Horvath, bring fresh perspectives and help ensure the most current information is presented. UPDATED! Thoroughly revised and peer-reviewed chapters provide you with the most current information possible.

Author : Sergio Cova
Publisher : Elsevier Inc. Chapters
Page : 76 pages
File Size : 22,39 MB
Release : 2013-11-29
Category : Science
ISBN : 012805803X

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This chapter presents a broad review of the principle, design, fabrication, operation, and performance of single-photon avalanche diodes (SPADs), and provides a comparative basis to assess the relative merits of the wide variety of devices and techniques covered. Particular attention is paid to the design of and operation of both silicon and high-speed-gated InGaAs/InP detection systems, as well as array-based systems.

Author : Tuan Vo-Dinh
Publisher : CRC Press
Page : 2465 pages
File Size : 27,47 MB
Release : 2014-07-29
Category : Medical
ISBN : 1439863199

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This handbook presents the most recent technological advances and applications in the areas of biomedical photonics. This second edition contains introductory material and covers the state-of-the-art methods and instrumentation for biomedical photonic technologies. It integrates interdisciplinary research and development critically needed for scientists, engineers, manufacturers, teachers, students, and clinical providers to learn about the most recent advances and predicted trends in instrumentation and methods as well as clinical applications in important areas of biomedical photonics. Extensive references are provided to enhance further study.

Author : Mac E. Van Valkenburg
Publisher : Elsevier
Page : 1689 pages
File Size : 39,99 MB
Release : 2001-10-19
Category : Technology & Engineering
ISBN : 0080515967

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Reference Data for Engineers is the most respected, reliable, and indispensable reference tool for technical professionals around the globe. Written by professionals for professionals, this book is a complete reference for engineers, covering a broad range of topics. It is the combined effort of 96 engineers, scientists, educators, and other recognized specialists in the fields of electronics, radio, computer, and communications technology. By providing an abundance of information on essential, need-to-know topics without heavy emphasis on complicated mathematics, Reference Data for Engineers is an absolute "must-have" for every engineer who requires comprehensive electrical, electronics, and communications data at his or her fingertips. Featured in the Ninth Edition is updated coverage on intellectual property and patents, probability and design, antennas, power electronics, rectifiers, power supplies, and properties of materials. Useful information on units, constants and conversion factors, active filter design, antennas, integrated circuits, surface acoustic wave design, and digital signal processing is also included. The Ninth Edition also offers new knowledge in the fields of satellite technology, space communication, microwave science, telecommunication, global positioning systems, frequency data, and radar. * Widely acclaimed as the most practical reference ever published for a wide range of electronics and computer professionals, from technicians through post-graduate engineers. * Provides a great way to learn or review the basics of various technologies, with a minimum of tables, equations, and other heavy math.

Author : Kimberly Kolb
Publisher :
Page : 420 pages
File Size : 27,9 MB
Release : 2015
Category : Avalanche photodiodes
ISBN :

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"This dissertation presents the current state-of-the-art of semiconductor-based photon counting detector technologies. HgCdTe linear-mode avalanche photodiodes (LM-APDs), silicon Geiger-mode avalanche photodiodes (GM-APDs), and electron-multiplying CCDs (EMCCDs) are compared via their present and future performance in various astronomy applications. LM-APDs are studied in theory, based on work done at the University of Hawaii. EMCCDs are studied in theory and experimentally, with a device at NASA's Jet Propulsion Lab. The emphasis of the research is on GM-APD imaging arrays, developed at MIT Lincoln Laboratory and tested at the RIT Center for Detectors. The GM-APD research includes a theoretical analysis of SNR and various performance metrics, including dark count rate, afterpulsing, photon detection efficiency, and intrapixel sensitivity. The effects of radiation damage on the GM-APD were also characterized by introducing a cumulative dose of 50 krad(Si) via 60 MeV protons. Extensive development of Monte Carlo simulations and practical observation simulations was completed, including simulated astronomical imaging and adaptive optics wavefront sensing. Based on theoretical models and experimental testing, both the current state-of-the-art performance and projected future performance of each detector are compared for various applications. LM-APD performance is currently not competitive with other photon counting technologies, and are left out of the application-based comparisons. In the current state-of-the-art, EMCCDs in photon counting mode out-perform GM-APDs for long exposure scenarios, though GM-APDs are better for short exposure scenarios (fast readout) due to clock-induced-charge (CIC) in EMCCDs. In the long term, small improvements in GM-APD dark current will make them superior in both long and short exposure scenarios for extremely low flux. The efficiency of GM-APDs will likely always be less than EMCCDs, however, which is particularly disadvantageous for moderate to high flux rates where dark noise and CIC are insignificant noise sources. Research into decreasing the dark count rate of GM-APDs will lead to development of imaging arrays that are competitive for low light level imaging and spectroscopy applications in the near future.."--Abstract.

Author : Claude Leroy
Publisher : World Scientific
Page : 950 pages
File Size : 13,24 MB
Release : 2010
Category : Medical
ISBN : 9814307521

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Beam test results with a highly granular Analog Hadron Calorimeter Prototype (AHCAL) / S. Morozov -- Validation of the hadronic calibration of the ATLAS calorimeter with test beam data corresponding to the pseudorapidity range 2.5