[PDF] Interactions Between Proteins And Small Solutes At The Protein Solvent Interface eBook

Author : Harry Brown
Publisher : Elsevier
Page : 340 pages
File Size : 32,92 MB
Release : 2012-12-02
Category : Science
ISBN : 032315526X

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Chemistry of the Cell Interface, Part B deals with the relationship of structure to biochemical reactions. This book is divided into three chapters. Chapter VI focuses on the water's contribution to the reaction systems, emphasizing the nature of the cell's aqueous phases. The matrix-supported enzymes, technology of the model, and properties of enzymes bound to polymeric matrices that have been contrasted with solution and membrane particle systems are elaborated in Chapter VII. The last chapter focuses on the aspects of protein chemistry pertinent to the design of interface experimental systems. Other topics include the structure of water near interfaces, functional role of water in biological systems, and adsorbed and ionically bonded enzymes. The enzymes insolubilized by the use of bridging compounds and changes in protein conformation associated with chemical modification are likewise covered in this text. This publication is a good source for morphologists, chemists, and specialists of disciplines related to the chemistry of cell interface.

Author : Jennifer J. McManus
Publisher : Humana
Page : 266 pages
File Size : 27,22 MB
Release : 2020-08-08
Category : Science
ISBN : 9781493996803

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This volume explores experimental and computational approaches to measuring the most widely studied protein assemblies, including condensed liquid phases, aggregates, and crystals. The chapters in this book are organized into three parts: Part One looks at the techniques used to measure protein-protein interactions and equilibrium protein phases in dilute and concentrated protein solutions; Part Two describes methods to measure kinetics of aggregation and to characterize the assembled state; and Part Three details several different computational approaches that are currently used to help researchers understand protein self-assembly. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Thorough and cutting-edge, Protein Self-Assembly: Methods and Protocols is a valuable resource for researchers who are interested in learning more about this developing field.

Author : Mark A. Williams
Publisher : Humana
Page : 0 pages
File Size : 37,92 MB
Release : 2016-11-17
Category : Science
ISBN : 9781493958733

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Proteins are the cell’s workers, their messengers and overseers. In these roles, proteins specifically bind small molecules, nucleic acid and other protein partners. Cellular systems are closely regulated and biologically significant changes in populations of particular protein complexes correspond to very small variations of their thermodynamics or kinetics of reaction. Interfering with the interactions of proteins is the dominant strategy in the development of new pharmaceuticals. Protein Ligand Interactions: Methods and Applications, Second Edition provides a complete introduction to common and emerging procedures for characterizing the interactions of individual proteins. From the initial discovery of natural substrates or potential drug leads, to the detailed quantitative understanding of the mechanism of interaction, all stages of the research process are covered with a focus on those techniques that are, or are anticipated to become, widely accessible and performable with mainstream commercial instrumentation. Written in the highly successful Methods in Molecular Biology series format, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and accessible, Protein Ligand Interactions: Methods and Applications, Second Edition serves as an ideal guide for researchers new to the field of biophysical characterization of protein interactions – whether they are beginning graduate students or experts in allied areas of molecular cell biology, microbiology, pharmacology, medicinal chemistry or structural biology.

Author : Juan M. Ruso
Publisher : John Wiley & Sons
Page : 823 pages
File Size : 33,63 MB
Release : 2013-01-31
Category : Science
ISBN : 1118523172

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Explores new applications emerging from our latest understanding of proteins in solution and at interfaces Proteins in solution and at interfaces increasingly serve as the starting point for exciting new applications, from biomimetic materials to nanoparticle patterning. This book surveys the state of the science in the field, offering investigators a current understanding of the characteristics of proteins in solution and at interfaces as well as the techniques used to study these characteristics. Moreover, the authors explore many of the new and emerging applications that have resulted from the most recent studies. Topics include protein and protein aggregate structure; computational and experimental techniques to study protein structure, aggregation, and adsorption; proteins in non-standard conditions; and applications in biotechnology. Proteins in Solution and at Interfaces is divided into two parts: Part One introduces concepts as well as theoretical and experimental techniques that are used to study protein systems, including X-ray crystallography, nuclear magnetic resonance, small angle scattering, and spectroscopic methods Part Two examines current and emerging applications, including nanomaterials, natural fibrous proteins, and biomolecular thermodynamics The book's twenty-three chapters have been contributed by leading experts in the field. These contributions are based on a thorough review of the latest peer-reviewed findings as well as the authors' own research experience. Chapters begin with a discussion of core concepts and then gradually build in complexity, concluding with a forecast of future developments. Readers will not only gain a current understanding of proteins in solution and at interfaces, but also will discover how theoretical and technical developments in the field can be translated into new applications in material design, genetic engineering, personalized medicine, drug delivery, biosensors, and biotechnology.

Author : Biman Bagchi
Publisher : Cambridge University Press
Page : 383 pages
File Size : 46,82 MB
Release : 2013-11-14
Category : Medical
ISBN : 1107037298

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A unified overview of the dynamical properties of water and its unique and diverse role in biological and chemical processes.

Author : Roger Gregory
Publisher : CRC Press
Page : 596 pages
File Size : 24,15 MB
Release : 1995-01-04
Category : Science
ISBN : 9780824792398

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This work covers advances in the interactions of proteins with their solvent environment and provides fundamental physical information useful for the application of proteins in biotechnology and industrial processes. It discusses in detail structure, dynamic and thermodynamic aspects of protein hydration, as well as proteins in aqueous and organic solvents as they relate to protein function, stability and folding.